{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:06Z","timestamp":1792785966576,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022720","name":"Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022720","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hong Kong Special Administrative Region Government","award":["#22210282"],"award-info":[{"award-number":["#22210282"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mycoplasma genitalium is a cause of sexually transmitted infections (STIs). This study assessed its prevalence, resistance and coinfection with Chlamydia trachomatis\/Neisseria gonorrhoeae infections in MSM with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MSM in HIV care in Hong Kong were recruited during 2023\u201324 for completion of an online survey, and self-collection of urine specimens, rectal and pharyngeal swabs, which were tested for C. trachomatis, N. gonorrhoeae, M. genitalium and M. genitalium resistance-associated mutations (RAMs). The main outcome variables included M. genitalium infection and RAMs at individual and anatomic-site levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Among 562 MSM with HIV aged 20\u201371\u2005years, all-site prevalence was 20% for M. genitalium, 19% for C. trachomatis and 10% for N. gonorrhoeae. Among C. trachomatis\/N. gonorrhoeae infections, 28% were coinfected with M. genitalium. The prevalence was highest at the rectal site for M. genitalium (14%), C. trachomatis (17%) and N. gonorrhoeae (8%). M. genitalium infection was associated with N. gonorrhoeae (OR\u200a=\u200a3.29 at the individual level, OR\u200a=\u200a4.76 at pharyngeal sites and OR\u200a=\u200a4.00 at rectal sites) but not C. trachomatis infection. Among 102 typeable M. genitalium-positive samples, 88 (86%) had RAMs\u2014macrolides (78%), fluoroquinolones (49%) and both (41%). Recent sexualized drug use was a significant predictor for urethral M. genitalium RAMs [adjusted OR (aOR)\u200a=\u200a3.21], while prolonged symptoms (aOR\u200a=\u200a4.82), N. gonorrhoeae coinfection (aOR\u200a=\u200a3.19) and HIV diagnosis in 2015\u201319 (aOR\u200a=\u200a6.20) were predictors for rectal RAMs. The cure rate for non-susceptible M. genitalium infection was satisfactory with moxifloxacin or minocycline but not with azithromycin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>M. genitalium RAM prevalence is high in MSM with HIV, in whom rectal infection and C. trachomatis\/N. gonorrhoeae coinfections are common.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jacamr\/dlaf158","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:45:09Z","timestamp":1755863109000},"source":"Crossref","is-referenced-by-count":7,"title":["Multi-anatomical site prevalence of\n                    <i>Mycoplasma genitalium<\/i>\n                    infection, resistance and association with coinfections: a prospective study in MSM with HIV"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-8114","authenticated-orcid":false,"given":"Ngai Sze","family":"Wong","sequence":"first","affiliation":[{"name":"JC School of Public Health and Primary Care, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]},{"name":"Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]},{"name":"S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie Chun Kwan","family":"Wong","sequence":"additional","affiliation":[{"name":"Special Preventive Programme, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region Government , Hong Kong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Pui-Chung","family":"Chan","sequence":"additional","affiliation":[{"name":"Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]},{"name":"S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny King Fai","family":"Cheung","sequence":"additional","affiliation":[{"name":"Special Preventive Programme, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region Government , Hong Kong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather Ki Wai","family":"To","sequence":"additional","affiliation":[{"name":"Special Preventive Programme, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region Government , Hong Kong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze Long","family":"Chung","sequence":"additional","affiliation":[{"name":"Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]},{"name":"S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-6537","authenticated-orcid":false,"given":"Margaret","family":"Ip","sequence":"additional","affiliation":[{"name":"S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]},{"name":"Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui Shan","family":"Lee","sequence":"additional","affiliation":[{"name":"Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]},{"name":"S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong , Hong Kong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"2025092304270214200_dlaf158-B1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1136\/sextrans-2017-053384","article-title":"Prevalence of Mycoplasma genitalium in different population groups: systematic review and meta-analysis","volume":"94","author":"Baumann","year":"2018","journal-title":"Sex Transm Infect"},{"key":"2025092304270214200_dlaf158-B2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1136\/sextrans-2022-055687","article-title":"Prevalence of Mycoplasma genitalium infection among HIV PrEP users: a systematic review and meta-analysis","volume":"99","author":"Sokoll","year":"2023","journal-title":"Sex Transm 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