{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:30:52Z","timestamp":1791592252534,"version":"4.3.4"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Africa Research Excellence Fund","award":["AREF-320-OLAL-F-C0871"],"award-info":[{"award-number":["AREF-320-OLAL-F-C0871"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Multidrug-resistant Staphylococcus aureus accounts for a significant proportion of antimicrobial resistance (AMR)-associated infections worldwide. This study investigated the molecular profile of MRSA in Nigeria, providing valuable genomic data to fill existing knowledge gaps and highlighting its importance in the context of the global AMR crisis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 107 isolates were obtained from patient samples, including wound swabs\/pus (65 isolates, 60.7%), blood cultures (16 isolates, 15%), urine\/urinary catheter (8 isolates, 7.5%) and other sources. Species identification was performed using MALDI-TOF, and antimicrobial susceptibility testing was performed using the VITEK\u00ae2 system. Genomic DNA was extracted and subjected to whole-genome sequencing using short-read Illumina technology. In addition, a subset of isolates underwent long-read sequencing using Oxford Nanopore technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 107 isolates, 63 (59%) were identified as MRSA, with 58 (92%) carrying the mecA gene. The MRSA isolates exhibited high resistance to non-\u03b2-lactam antibiotics, particularly trimethoprim\/sulfamethoxazole (95.3%), erythromycin (76.6%), gentamicin (71.4%) and quinolones (69.8%). The most prevalent MRSA belonged to the Bengal Bay clone [t657\/ST772\/Staphylococcal Cassette Chromosome mec (SCCmec) V(5C2)\/Panton-Valentine leukocidin (PVL)\u200a+\u200aMRSA], followed by t4690\/ST152\/SCCmec Vc(5C2&amp;5)\/PVL\u200a+\u200aMRSA and ST8 (t008, n\u200a=\u200a1; t064, n\u200a=\u200a4)\/SCCmec Vc(5C2&amp;5). Phylogenetic analysis suggests both community-associated transmission and possible importation of strains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the significant burden of MRSA in Nigeria, with the high-risk Bengal Bay MRSA clone as the most common strain. The widespread resistance to non-\u03b2-lactam antibiotics underscores the urgent need for enhanced surveillance, infection control and antibiotic stewardship to mitigate its spread.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jacamr\/dlaf161","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:49:38Z","timestamp":1756381778000},"source":"Crossref","is-referenced-by-count":8,"title":["Molecular landscape of methicillin-resistant\n                    <i>Staphylococcus aureus<\/i>\n                    strains in clinical infections from hospitals in Lagos, Nigeria"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9203-8801","authenticated-orcid":false,"given":"Adesola","family":"Olalekan","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, College of Medicine, University of Lagos , Lagos 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Yorkshire Genomic Laboratory Hub, Central Lab, St. James\u2019s University Hospital , Leeds ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Galarion","sequence":"additional","affiliation":[{"name":"Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds , Leeds ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solayide","family":"Adesida","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science, University of Lagos , Akoka, Lagos ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-2797","authenticated-orcid":false,"given":"Bamidele","family":"Iwalokun","sequence":"additional","affiliation":[{"name":"Molecular Biology & Biotechnology Department, Nigerian Institute of Medical Research , Lagos ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olayiwola","family":"Popoola","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, College of Medicine, University of Lagos , Lagos ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seraphine","family":"Esemu","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Science, University of Buea , Buea ,","place":["Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Adegbola","sequence":"additional","affiliation":[{"name":"Molecular Biology & Biotechnology Department, Nigerian Institute of Medical Research , Lagos 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