{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:16:13Z","timestamp":1783192573391,"version":"3.54.6"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Antimicrobial resistance (AMR) is increasingly recognized as a complex issue that requires an interdisciplinary One Health approach to find solutions. While early surveillance efforts have emphasized clonal expansion of resistant pathogens, recent genomic studies demonstrate that plasmid-mediated horizontal gene transfer is a dominant force shaping the global AMR landscape. Mobile resistance determinants conferring reduced susceptibility to critically important antimicrobials, including extended-spectrum \u03b2-lactams, quinolones, colistin, tigecycline and carbapenems, are now widely detected across food-producing animals, retail foods, environmental waters and human clinical isolates. In this review, we synthesize genomic evidence supporting cross-sector transmission of plasmid-mediated AMR, with a focus on key resistance genes (blaCTX-M, qnr, mcr, tet(X), blaNDM), and their associated plasmid backbones. We discuss why certain plasmids are particularly successful across diverse ecological niches and highlight implications for surveillance and mitigation strategies within a One Health framework. Rather than proposing a new One Health framework, this review synthesizes current genomic evidence highlighting the role of plasmids as major vehicles of AMR dissemination across interconnected reservoirs.<\/jats:p>","DOI":"10.1093\/jacamr\/dlag130","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:58:03Z","timestamp":1782302283000},"source":"Crossref","is-referenced-by-count":0,"title":["One Health transmission of plasmid-mediated antimicrobial resistance: genomic insights at the interface of food, animals, humans and the environment"],"prefix":"10.1093","volume":"8","author":[{"given":"Daniel F M","family":"Monte","sequence":"first","affiliation":[{"name":"Department of Population Health and Pathobiology, North Carolina State University, College of Veterinary Medicine , Raleigh, NC 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