{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T03:30:09Z","timestamp":1786332609406,"version":"build-2736575974"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002999","name":"Dutch Ministry of Health, Welfare and Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Colonization by antimicrobial-resistant bacteria can cause difficult-to-treat infections, yet their carriage prevalence in Suriname is unknown. This cross-sectional study assessed intestinal community carriage and the molecular epidemiology of pathogens of public health importance, including carbapenemase-producing Enterobacterales (CPE), ESBL-producing coliforms (ESBL-c) and MRSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Faecal samples were collected from 310 non-hospitalized patients between October 2024 and February 2025 and analysed using selective culture and WGS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of ESBL carriage was 12.3% (95% CI: 8.4%\u201315.6%). Most ESBL\/plasmid-mediated AmpC genes belonged to the blaCTX-M-1-group. Among the detected ESBL-c isolates, four distinct genetic clusters were identified: two clusters had identical core genomes, and two clusters had related ones (\u226410 allelic differences). No CPE were detected. Two MRSA and one Staphylococcus argenteus (MRSArg) with mecA genes were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated frequent ESBL carriage in community-dwelling individuals attending ambulatory care in Suriname. Genomic clustering suggests transmission or shared sources. In contrast, carriage of CPE and MRSA was uncommon. These findings may help clinicians and policymakers to make informed decisions and develop targeted strategies to limit the spread of antimicrobial resistance and improve global public health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jacamr\/dlag169","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:53:40Z","timestamp":1785243220000},"source":"Crossref","is-referenced-by-count":0,"title":["Carriage rate of CPE, ESBL-producing coliforms and MRSA in community settings in Suriname"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1793-7558","authenticated-orcid":false,"given":"Carlotte M","family":"Rozemond","sequence":"first","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM) , Centre for Infectious Disease Control, Antonie van Leeuwenhoeklaan 9, Bilthoven ,","place":["The Netherlands"]},{"name":"Department of Infectious Diseases, Leiden University Medical Centre , Albinusdreef 2, Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malti R","family":"Adhin","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Department of Biochemistry, Anton de Kom Universiteit van Suriname , Kernkampweg 5, Paramaribo ,","place":["Suriname"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Williams","sequence":"additional","affiliation":[{"name":"N.V. MyLab , Carusostraat 1, Paramaribo ,","place":["Suriname"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine C","family":"De Greeff","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM) , Centre for Infectious Disease Control, Antonie van Leeuwenhoeklaan 9, Bilthoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engeline","family":"Van Duijkeren","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM) , Centre for Infectious Disease Control, Antonie van Leeuwenhoeklaan 9, Bilthoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G","family":"Vreden","sequence":"additional","affiliation":[{"name":"Foundation for the Advancement of Scientific Research Suriname (SWOS) , K.P. van Westenstraat 9, Paramaribo ,","place":["Suriname"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis T","family":"Mawie","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Academic Hospital Paramaribo , Flustraat, Paramaribo ,","place":["Suriname"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Ijzerman","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Academic Hospital Paramaribo , Flustraat, Paramaribo ,","place":["Suriname"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Hordijk","sequence":"additional","affiliation":[{"name":"National Institute for Public Health and the Environment (RIVM) , Centre for Infectious Disease Control, Antonie van Leeuwenhoeklaan 9, Bilthoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap T","family":"Van Dissel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Leiden University Medical Centre , Albinusdreef 2, Leiden ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2026080923173607900_dlag169-B1","author":"WHO"},{"key":"2026080923173607900_dlag169-B2","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Antimicrobial Resistance Collaborators","year":"2022","journal-title":"Lancet"},{"key":"2026080923173607900_dlag169-B3","doi-asserted-by":"publisher","first-page":"e357","DOI":"10.1016\/S2542-5196(19)30130-5","article-title":"Attributable sources of community-acquired carriage of Escherichia coli containing \u03b2-lactam antibiotic resistance genes: a population-based modelling study","volume":"3","author":"Mughini-Gras","year":"2019","journal-title":"Lancet Planet Health"},{"key":"2026080923173607900_dlag169-B4","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1017\/ice.2019.5","article-title":"ESBL-colonization at ICU admission: impact on subsequent infection, carbapenem-consumption, and outcome","volume":"40","author":"Emmanuel Martinez","year":"2019","journal-title":"Infect Control Hosp Epidemiol"},{"key":"2026080923173607900_dlag169-B5","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S0140-6736(04)16897-9","article-title":"Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers","volume":"364","author":"Wertheim","year":"2004","journal-title":"Lancet"},{"key":"2026080923173607900_dlag169-B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nexres.2026.102231","article-title":"Superbugs exposed: the occurrence of antimicrobial-resistant bacteria in food-producing animals in Suriname","volume":"12","author":"Rozemond","year":"2026","journal-title":"Nex Res"},{"key":"2026080923173607900_dlag169-B7","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000567","article-title":"Harmonization of whole-genome sequencing for outbreak surveillance of Enterobacteriaceae and enterococci","volume":"7","author":"Jamin","year":"2021","journal-title":"Microb Genom"},{"key":"2026080923173607900_dlag169-B8","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1128\/JCM.00029-17","article-title":"Comparison of whole-genome sequencing methods for analysis of three methicillin-resistant Staphylococcus aureus outbreaks","volume":"55","author":"Cunningham","year":"2017","journal-title":"J Clin Microbiol"},{"key":"2026080923173607900_dlag169-B9","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlac048","article-title":"Comparison of the global prevalence and trend of human intestinal carriage of ESBL-producing Escherichia coli between healthcare and community settings: a systematic review and meta-analysis","volume":"4","author":"Bezabih","year":"2022","journal-title":"JAC Antimicrob Resist"},{"key":"2026080923173607900_dlag169-B10","doi-asserted-by":"publisher","first-page":"21275","DOI":"10.1038\/s41598-025-94750-3","article-title":"Colonization with antibiotic resistant bacteria in communities and hospitals across six countries, including Bangladesh, Botswana, Chile, Guatemala, India, and Kenya","volume":"15","author":"Parra","year":"2025","journal-title":"Sci Rep"},{"key":"2026080923173607900_dlag169-B11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s42770-021-00673-2","article-title":"High levels of gut carriage of antimicrobial-resistant Escherichia coli in community settings in Rio de Janeiro, Brazil","volume":"53","author":"de Pinho Rodrigues","year":"2022","journal-title":"Braz J Microbiol"},{"key":"2026080923173607900_dlag169-B12","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/j.1469-0691.2012.03947.x","article-title":"High prevalence of ESBL-producing Enterobacteriaceae carriage in Dutch community patients with gastrointestinal complaints","volume":"19","author":"Reuland","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"2026080923173607900_dlag169-B13","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.2147\/IDR.S371845","article-title":"Extended-spectrum beta-lactamases producing Escherichia coli in South America: a systematic review with a one health perspective","volume":"15","author":"Bastidas-Caldes","year":"2022","journal-title":"Infect Drug Resist"},{"key":"2026080923173607900_dlag169-B14","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2019.24.41.1800594","article-title":"Prevalence, risk factors and genetic characterisation of extended-spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae (ESBL-E and CPE): a community-based cross-sectional study, the Netherlands, 2014 to 2016","volume":"24","author":"van den Bunt","year":"2019","journal-title":"Euro Surveill"},{"key":"2026080923173607900_dlag169-B15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10096-008-0602-7","article-title":"Intestinal carriage of Staphylococcus aureus: how does its frequency compare with that of nasal carriage and what is its clinical impact?","volume":"28","author":"Acton","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2026080923173607900_dlag169-B16","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3855\/jidc.10552","article-title":"Prevalence of methicillin resistant Staphylococcus aureus (MRSA) in pigs and workers at abattoirs in Trinidad and Tobago","volume":"13","author":"Stewart-Johnson","year":"2019","journal-title":"J Infect Dev Ctries"},{"key":"2026080923173607900_dlag169-B17","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12050862","article-title":"Staphylococcus aureus and CA-MRSA carriage among Brazilian Indians living in peri-urban areas and remote communities","volume":"12","author":"Abra\u00e3o","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"2026080923173607900_dlag169-B18","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946201860058","article-title":"Prevalence of methicillin-resistant Staphylococcus aureus colonization in individuals from the community in the city of Sao Paulo, Brazil","volume":"60","author":"Bes","year":"2018","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"2026080923173607900_dlag169-B19","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ijid.2014.08.007","article-title":"Molecular epidemiology of Staphylococcus aureus in post-earthquake northern Haiti","volume":"29","author":"Rosenthal","year":"2014","journal-title":"Int J Infect Dis"},{"key":"2026080923173607900_dlag169-B20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jhin.2021.12.016","article-title":"Gastrointestinal colonization of meticillin-resistant Staphylococcus aureus: an unrecognized burden upon hospital infection control","volume":"121","author":"Wong","year":"2022","journal-title":"J Hosp Infect"},{"key":"2026080923173607900_dlag169-B21","doi-asserted-by":"publisher","first-page":"S399","DOI":"10.14309\/00000434-201310001-01342","article-title":"MRSA colitis: an uncommon manifestation of a common pathogen: 1342","volume":"108","author":"Kalakonda","year":"2013","journal-title":"Am J Gastroentero"}],"container-title":["JAC-Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/8\/4\/dlag169\/70581234\/dlag169.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/8\/4\/dlag169\/70581234\/dlag169.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T03:17:42Z","timestamp":1786331862000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jacamr\/article\/doi\/10.1093\/jacamr\/dlag169\/8757710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jacamr\/dlag169","relation":{},"ISSN":["2632-1823"],"issn-type":[{"value":"2632-1823","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,7,2]]},"article-number":"dlag169"}}