{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:18:16Z","timestamp":1788337096102,"version":"build-2803163510"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003388","name":"French Ministry for Europe and Foreign Affairs","doi-asserted-by":"publisher","award":["2021-94"],"award-info":[{"award-number":["2021-94"]}],"id":[{"id":"10.13039\/501100003388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The global health threat of antimicrobial resistance involves the human, animal and environmental sectors. Data from Cameroon are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to define extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-Ec) rates and associated risk factors across the three sectors in Douala, Cameroon, and to define molecular characteristics of isolates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From June 2022 to May 2023, we collected blood cultures from hospitalized patients, rectal swabs from healthy pregnant women, caeca from broiler chickens and environmental wastewater. Samples were screened for ESBL-Ec using CHROMAgar\u2122 ESBL and cefotaxime-supplemented Tryptone Bile X-glucuronide agar. Antimicrobial susceptibility testing was performed by disk diffusion following EUCAST guidelines. Whole-genome sequencing was carried out using Illumina technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 628 samples, 374 yielded ESBL-Ec. Prevalence was 54.6% (131\/240) in pregnant women, 70.4% (169\/240) in chickens and 93.1% (67\/72) in wastewater. The proportion of ESBL-Ec among E. coli-positive-blood cultures was 9.2% (7\/76). Multi-family household living was independently associated with ESBL-Ec carriage among pregnant women (adjusted odds ratio\u200a=\u200a1.7, 95% CI 1.0\u20133.1, P\u200a=\u200a0.03). High co-resistance (&amp;gt;70%) was observed for tetracycline, ciprofloxacin and trimethoprim\/sulfamethoxazole. Sequencing of 32 isolates revealed 45 distinct resistance genes, including blaCTX-M-15 (n\u200a=\u200a13, 40.6%), blaCTX-M-55 (n\u200a=\u200a11, 34.4%) and last-resort antibiotic resistance genes mcr-1 and blaOXA-181. High-risk sequence types included ST131 (pregnant women) and ST10 (chickens). Notably, ST48 was shared between pregnant women and chickens, and ST155 between pregnant women and wastewater.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cross-sectoral ESBL-Ec in Douala exhibits high genomic diversity and alarming resistance. The occurrence of last-resort genes requires immediate One Health surveillance and coordinated interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jacamr\/dlag194","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:48:49Z","timestamp":1787226529000},"source":"Crossref","is-referenced-by-count":0,"title":["Genomic epidemiology of extended-spectrum beta-lactamase-producing\n                    <i>Escherichia coli<\/i>\n                    across humans, poultry and wastewater sectors in Douala, Cameroon"],"prefix":"10.1093","volume":"8","author":[{"given":"Ars\u00e8ne","family":"Djoko Nono","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science, Faculty of Health Sciences, University of Buea , PO Box 63 Buea ,","place":["Cameroon"]},{"name":"Department of Hygiene and Environment Microbiology Section, Centre Pasteur of Cameroon , PO Box 1274 Yaounde 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Epidemiology and Modelling of Bacterial escape to Antimicrobials (EMAE), Institut Pasteur, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Anti-infective Evasion and Pharmacoepidemiology Team, Universit\u00e9 Paris-Saclay, UVSQ, CESP, Inserm , Montigny-le-Bretonneux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8948-1941","authenticated-orcid":false,"given":"Chiara","family":"Crestani","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Biodiversity and Epidemiology of Bacterial Pathogens , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrette Landrie","family":"Simo Tchuinte","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Environment Microbiology Section, Centre Pasteur of Cameroon , PO Box 1274 Yaounde 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Universit\u00e9 Paris-Saclay, UVSQ, CESP, Inserm , Montigny-le-Bretonneux ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2516-2108","authenticated-orcid":false,"given":"Sylvain","family":"Brisse","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Biodiversity and Epidemiology of Bacterial Pathogens , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Breurec","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hyacinthe Bastaraud, University of the Antilles , Pointe-\u00e0-Pitre ,","place":["France"]},{"name":"Clinical Microbiology Laboratory, University Hospital of Guadeloupe , Pointe-\u00e0-Pitre, Guadeloupe ,","place":["France"]},{"name":"Caribbean Clinical Investigation Center, Inserm CIC 2504, University Hospital of Guadeloupe , Pointe-\u00e0-Pitre 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