{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:43:03Z","timestamp":1789501383656,"version":"build-2803163510"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Sciences and Engineering Research Council of Canada (NSERC) Canada Graduate Scholarship"},{"name":"NSERC CREATE"},{"name":"NSERC Discovery Grants"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Thiamine deficiency is a widespread issue in salmonine species and has been reported to induce changes in cardiac morphology and cardiac dysfunction in Lake Trout Salvelinus namaycush. Here, we assess the effects of thiamine concentration on the ventricular morphology of three reproductive life histories (jack males, hooknose males, and females) of wild spawning Chinook Salmon Oncorhynchus tshawytscha.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Fish were sampled from the Credit River (a Lake Ontario tributary), and skeletal muscle, ventricle, and liver thiamine concentrations were quantified using high-performance liquid chromatography. A subset of ventricles was retained for histological analyses. Hematoxylin and eosin-stained slides were used to measure cardiomyocyte width and compact myocardium thickness, and Masson\u2019s trichrome-stained slides were used to measure levels of cardiac fibrosis. Level of spawning senescence was quantified based on a qualitative score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thiamine levels did not differ significantly among life histories, except that hooknose males had significantly greater skeletal muscle thiamine concentrations than females. Thiamine concentrations in skeletal muscle and the ventricle were positively correlated. Across all life histories, lower concentrations of thiamine in skeletal muscle were associated with increased levels of cardiomyocyte hypertrophy and cardiac fibrosis, independent of their relationships with ventricle mass and level of spawning senescence. No significant relationships were observed with compact myocardium thickness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Low thiamine concentrations are associated with pathological alterations in cardiac morphology across reproductive life histories in spawning Chinook Salmon.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jahafs\/vsaf007","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T20:26:50Z","timestamp":1748377610000},"page":"55-65","source":"Crossref","is-referenced-by-count":3,"title":["Low thiamine concentrations are associated with altered cardiac morphology across reproductive life histories of\u00a0spawning Chinook Salmon"],"prefix":"10.1093","volume":"37","author":[{"given":"K A","family":"Adeli","sequence":"first","affiliation":[{"name":"Department of Biology, University of Western Ontario , London, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T E","family":"Pitcher","sequence":"additional","affiliation":[{"name":"Great Lakes Institute for Environmental Research, University of Windsor , Windsor, Ontario ,","place":["Canada"]},{"name":"Department of Integrative Biology, University of Windsor , Windsor, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Environmental Science and Ecology, SUNY Brockport , Brockport, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rinchard","sequence":"additional","affiliation":[{"name":"Department of Environmental Science and Ecology, SUNY Brockport , Brockport, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B D","family":"Neff","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Western Ontario , London, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"2025061300563974000_vsaf007-B1","doi-asserted-by":"publisher","first-page":"102423","DOI":"10.1016\/j.jglr.2024.102423","article-title":"Comparisons of isotopic niche between females and male alternative reproductive tactics of Chinook Salmon (Oncorhynchus tshawytscha) from Lake Ontario","volume":"50","author":"Adeli","year":"2024","journal-title":"Journal of Great Lakes Research"},{"key":"2025061300563974000_vsaf007-B2","doi-asserted-by":"publisher","first-page":"Article 0069","DOI":"10.1139\/cjz-2024-0069","article-title":"Consumption of non-native Rainbow Smelt (Osmerus mordax) is associated with changes in the heart morphology of wild Lake Trout (Salvelinus namaycush)","volume":"103","author":"Adeli","year":"2024","journal-title":"Canadian Journal of Zoology"},{"key":"2025061300563974000_vsaf007-B3","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fmars.2014.00076","article-title":"Association between swimming performance, cardiorespiratory morphometry, and thermal tolerance in Atlantic Salmon (Salmo salar L.)","volume":"1","author":"Anttila","year":"2014","journal-title":"Frontiers in Marine Science"},{"key":"2025061300563974000_vsaf007-B4","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1139\/cjz-2023-0012","article-title":"Dietary thiaminase impairs cardiac function and increases heart size in Lake Trout (Salvelinus namaycush (Walbaum in Artedi, 1792))","volume":"101","author":"Baker","year":"2023","journal-title":"Canadian Journal of Zoology"},{"key":"2025061300563974000_vsaf007-B5","doi-asserted-by":"publisher","first-page":"38821","DOI":"10.1038\/srep38821","article-title":"Widespread episodic thiamine deficiency in Northern Hemisphere wildlife","volume":"6","author":"Balk","year":"2016","journal-title":"Scientific Reports"},{"key":"2025061300563974000_vsaf007-B6","doi-asserted-by":"publisher","first-page":"Article 1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"Journal of Statistical Software"},{"key":"2025061300563974000_vsaf007-B7","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1139\/F10-112","article-title":"Mating success of alternative male phenotypes and evidence for frequency-dependent selection in Chinook Salmon, Oncorhynchus tshawytscha","volume":"67","author":"Berejikian","year":"2010","journal-title":"Canadian Journal of Fisheries and Aquatic Sciences"},{"key":"2025061300563974000_vsaf007-B8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1577\/H03-072.1","article-title":"Can diet-dependent factors help explain fish-to-fish variation in thiamine-dependent early mortality syndrome?","volume":"17","author":"Brown","year":"2005","journal-title":"Journal of Aquatic Animal Health"},{"key":"2025061300563974000_vsaf007-B9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1577\/H04-015.1","article-title":"Implications of thiamine deficiency in Great Lakes salmonines","volume":"17","author":"Brown","year":"2005","journal-title":"Journal of Aquatic Animal Health"},{"key":"2025061300563974000_vsaf007-B10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1577\/H04-059.1","article-title":"Thiamine status in adult salmonines in the Great Lakes","volume":"17","author":"Brown","year":"2005","journal-title":"Journal of Aquatic Animal Health"},{"key":"2025061300563974000_vsaf007-B11","doi-asserted-by":"publisher","author":"Brown","year":"1998","DOI":"10.47886\/9781888569087.ch8"},{"key":"2025061300563974000_vsaf007-B12","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.ygcen.2011.11.041","article-title":"Primary and secondary sexual characters in alternative reproductive tactics of Chinook Salmon: Associations with androgens and the maturation-inducing steroid","volume":"175","author":"Butts","year":"2012","journal-title":"General and Comparative Endocrinology"},{"key":"2025061300563974000_vsaf007-B13","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1242\/jeb.01587","article-title":"Linking swimming performance, cardiac pumping ability and cardiac anatomy in Rainbow Trout","volume":"208","author":"Claireaux","year":"2005","journal-title":"Journal of Experimental Biology"},{"key":"2025061300563974000_vsaf007-B14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1126\/science.1199158","article-title":"Differences in thermal tolerance among Sockeye Salmon populations","volume":"332","author":"Eliason","year":"2011","journal-title":"Science"},{"key":"2025061300563974000_vsaf007-B15","doi-asserted-by":"publisher","first-page":"cot008","DOI":"10.1093\/conphys\/cot008","article-title":"Cardiorespiratory collapse at high temperature in swimming adult Sockeye Salmon","volume":"1","author":"Eliason","year":"2013","journal-title":"Conservation Physiology"},{"key":"2025061300563974000_vsaf007-B16","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/S1095-6433(02)00049-1","article-title":"Cardiorespiratory performance in salmonids during exercise at high temperature: Insights into cardiovascular design limitations in fishes","volume":"132","author":"Farrell","year":"2002","journal-title":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology"},{"key":"2025061300563974000_vsaf007-B17","doi-asserted-by":"publisher","first-page":"3771","DOI":"10.1242\/jeb.023671","article-title":"Environment, antecedents and climate change: Lessons from the study of temperature physiology and river migration of salmonids","volume":"212","author":"Farrell","year":"2009","journal-title":"Journal of Experimental Biology"},{"key":"2025061300563974000_vsaf007-B18","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1086\/592057","article-title":"Pacific salmon in hot water: Applying aerobic scope models and biotelemetry to predict the success of spawning migrations","volume":"81","author":"Farrell","year":"2008","journal-title":"Physiological and Biochemical Zoology"},{"key":"2025061300563974000_vsaf007-B19","first-page":"1","volume-title":"Fish physiology","author":"Farrell","year":"1992"},{"key":"2025061300563974000_vsaf007-B20","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1002\/nafm.10659","article-title":"Ontogenetic dietary changes and thiamine status of Lake Ontario Chinook Salmon, 2005\u20132006","volume":"41","author":"Fitzsimons","year":"2021","journal-title":"North American Journal of Fisheries Management"},{"key":"2025061300563974000_vsaf007-B21","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1577\/H04-003.1","article-title":"The effect of thiamine injection on upstream migration, survival, and thiamine status of putative thiamine-deficient Coho Salmon","volume":"17","author":"Fitzsimons","year":"2005","journal-title":"Journal of Aquatic Animal Health"},{"key":"2025061300563974000_vsaf007-B22","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3394\/0380-1330(2007)33[93:ETSOLO]2.0.CO;2","article-title":"Egg thiamine status of Lake Ontario salmonines 1995\u20132004 with emphasis on Lake Trout","volume":"33","author":"Fitzsimons","year":"2007","journal-title":"Journal of Great Lakes Research"},{"key":"2025061300563974000_vsaf007-B23","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1095-8312.2012.01980.x","article-title":"Reproductive investment patterns, sperm characteristics, and seminal plasma physiology in alternative reproductive tactics of Chinook Salmon (Oncorhynchus tshawytscha)","volume":"108","author":"Flannery","year":"2013","journal-title":"Biological Journal of the Linnean Society"},{"key":"2025061300563974000_vsaf007-B24","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1111\/eth.12601","article-title":"The effects of paternal reproductive tactic and rearing environment on juvenile variation in growth as mediated through aggression and foraging behaviours of Chinook Salmon (Oncorhynchus tshawytscha)","volume":"123","author":"Forest","year":"2017","journal-title":"Ethology"},{"key":"2025061300563974000_vsaf007-B25","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s10709-016-9917-y","article-title":"Additive and non-additive genetic components of the jack male life history in Chinook Salmon (Oncorhynchus tshawytscha)","volume":"144","author":"Forest","year":"2016","journal-title":"Genetica"},{"key":"2025061300563974000_vsaf007-B26","doi-asserted-by":"publisher","first-page":"R827","DOI":"10.1152\/ajpregu.1983.245.6.R827","article-title":"Metabolic organization of liver during spawning migration of Sockeye Salmon","volume":"245","author":"French","year":"1983","journal-title":"American Journal of Physiology: Regulatory, Integrative and Comparative Physiology"},{"key":"2025061300563974000_vsaf007-B27","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.jglr.2019.08.005","article-title":"Diet predictions of Lake Ontario salmonines based on fatty acids and correlations between their fat content and thiamine concentrations","volume":"45","author":"Futia","year":"2019","journal-title":"Journal of Great Lakes Research"},{"key":"2025061300563974000_vsaf007-B28","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.jglr.2017.01.001","article-title":"Thiamine deficiency and the effectiveness of thiamine treatments through broodstock injections and egg immersion on Lake Ontario steelhead trout","volume":"43","author":"Futia","year":"2017","journal-title":"Journal of Great Lakes Research"},{"key":"2025061300563974000_vsaf007-B29","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.jglr.2019.05.010","article-title":"Evaluation of adult and offspring thiamine deficiency in salmonine species from Lake Ontario","volume":"45","author":"Futia","year":"2019","journal-title":"Journal of Great Lakes Research"},{"key":"2025061300563974000_vsaf007-B30","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1577\/1548-8659(1998)127&lt;0747:EODAOT&gt;2.0.CO;2","article-title":"Effect of dietary amprolium on tissue thiamin and Cayuga syndrome in Atlantic Salmon","volume":"127","author":"Fynn-Aikins","year":"1998","journal-title":"Transactions of the American Fisheries Society"},{"key":"2025061300563974000_vsaf007-B31","doi-asserted-by":"publisher","first-page":"e13616","DOI":"10.1371\/journal.pone.0013616","article-title":"Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells","volume":"5","author":"Gangolf","year":"2010","journal-title":"PLoS One"},{"key":"2025061300563974000_vsaf007-B32","doi-asserted-by":"publisher","first-page":"10532","DOI":"10.1073\/pnas.1815080115","article-title":"Deadly deficiency at the heart of an environmental mystery","volume":"115","author":"Gilbert","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"2025061300563974000_vsaf007-B33","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.numecd.2013.06.010","article-title":"Thiamine deficiency leads to reduced nitric oxide production and vascular dysfunction in rats","volume":"24","author":"Gioda","year":"2014","journal-title":"Nutrition, Metabolism, and Cardiovascular Diseases"},{"key":"2025061300563974000_vsaf007-B34","doi-asserted-by":"publisher","first-page":"H2039","DOI":"10.1152\/ajpheart.00820.2009","article-title":"Cardiac oxidative stress is involved in heart failure induced by thiamine deprivation in rats","volume":"298","author":"Gioda","year":"2010","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"2025061300563974000_vsaf007-B35","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s11160-018-9538-x","article-title":"Thiamine deficiency in fishes: causes, consequences, and potential solutions","volume":"28","author":"Harder","year":"2018","journal-title":"Reviews in Fish Biology and Fisheries"},{"key":"2025061300563974000_vsaf007-B36","first-page":"311","volume-title":"Pacific salmon life histories","author":"Healey","year":"1991"},{"key":"2025061300563974000_vsaf007-B37","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1439-0310.2011.01894.x","article-title":"Effects of paternal reproductive tactic on juvenile behaviour and kin recognition in Chinook Salmon (Oncorhynchus tshawytscha)","volume":"117","author":"Henkel","year":"2011","journal-title":"Ethology"},{"key":"2025061300563974000_vsaf007-B38","doi-asserted-by":"publisher","author":"Honeyfield","year":"1998","DOI":"10.47886\/9781888569087.ch18"},{"key":"2025061300563974000_vsaf007-B39","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1577\/H03-078.1","article-title":"Development of thiamine deficiencies and early mortality syndrome in Lake Trout by feeding experimental and feral fish diets containing thiaminase","volume":"17","author":"Honeyfield","year":"2005","journal-title":"Journal of Aquatic Animal Health"},{"key":"2025061300563974000_vsaf007-B40","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/S0380-1330(08)71603-4","article-title":"Thiamine and fatty acid content of Lake Michigan Chinook Salmon","volume":"34","author":"Honeyfield","year":"2008","journal-title":"Journal of Great Lakes Research"},{"key":"2025061300563974000_vsaf007-B41","doi-asserted-by":"publisher","first-page":"13","DOI":"10.23849\/npafcb6\/13.19","article-title":"Thiamine and lipid utilization in fasting Chinook Salmon","volume":"6","author":"Honeyfield","year":"2016","journal-title":"North Pacific Anadromous Fish Commission Bulletin"},{"key":"2025061300563974000_vsaf007-B42","doi-asserted-by":"publisher","author":"Ji","year":"1998","DOI":"10.47886\/9781888569087.ch11"},{"key":"2025061300563974000_vsaf007-B43","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1242\/jeb.053058","article-title":"Cortisol response to stress is associated with myocardial remodeling in salmonid fishes","volume":"214","author":"Johansen","year":"2011","journal-title":"Journal of Experimental Biology"},{"key":"2025061300563974000_vsaf007-B44","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1242\/jeb.135046","article-title":"Bigger is not better: Cortisol-induced cardiac growth and dysfunction in salmonids","volume":"220","author":"Johansen","year":"2017","journal-title":"Journal of Experimental Biology"},{"key":"2025061300563974000_vsaf007-B45","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jtherbio.2018.12.011","article-title":"Temperature and depth profiles of Chinook Salmon and the energetic costs of their long-distance homing migrations","volume":"79","author":"Keefer","year":"2019","journal-title":"Journal of Thermal Biology"},{"key":"2025061300563974000_vsaf007-B46","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3389\/fphys.2015.00427","article-title":"The dynamic nature of hypertrophic and fibrotic remodeling of the fish ventricle","volume":"6","author":"Keen","year":"2016","journal-title":"Frontiers in Physiology"},{"key":"2025061300563974000_vsaf007-B47","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1242\/jeb.128496","article-title":"Temperature-induced cardiac remodelling in fish","volume":"220","author":"Keen","year":"2017","journal-title":"Journal of Experimental Biology"},{"key":"2025061300563974000_vsaf007-B48","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1577\/M04-173.1","article-title":"Thiamine status of Cayuga Lake Rainbow Trout and its influence on spawning migration","volume":"25","author":"Ketola","year":"2005","journal-title":"North American Journal of Fisheries Management"},{"key":"2025061300563974000_vsaf007-B49","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1577\/M08-021.1","article-title":"Effect of thiamine status on probability of Lake Ontario Chinook Salmon spawning in the upper or lower sections of Salmon River, New York","volume":"29","author":"Ketola","year":"2009","journal-title":"North American Journal of Fisheries Management"},{"key":"2025061300563974000_vsaf007-B50","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1242\/jeb.69.1.247","article-title":"The oxygen transport system in trout (Salmo gairdneri) during sustained exercise","volume":"69","author":"Kiceniuk","year":"1977","journal-title":"Journal of Experimental Biology"},{"key":"2025061300563974000_vsaf007-B51","doi-asserted-by":"publisher","first-page":"e24464","DOI":"10.1371\/journal.pone.0024464","article-title":"Cardiac remodeling in fish: Strategies to maintain heart function during temperature change","volume":"6","author":"Klaiman","year":"2011","journal-title":"PLoS One"},{"key":"2025061300563974000_vsaf007-B52","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0380-1330(03)70426-2","article-title":"Importance of Lake Ontario embayments and nearshore habitats as nurseries for larval fishes with emphasis on Alewife (Alosa pseudoharengus)","volume":"29","author":"Klumb","year":"2003","journal-title":"Journal of Great Lakes Research"},{"key":"2025061300563974000_vsaf007-B53","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1086\/692168","article-title":"Competition for vitamin B1 (thiamin) structures numerous ecological interactions","volume":"92","author":"Kraft","year":"2017","journal-title":"The Quarterly Review of Biology"},{"key":"2025061300563974000_vsaf007-B54","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1007\/BF02682257","article-title":"Antioxidant properties of thiamine","volume":"130","author":"Lukienko","year":"2000","journal-title":"Bulletin of Experimental Biology and Medicine"},{"key":"2025061300563974000_vsaf007-B55","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1021\/bi401618y","article-title":"Thiamin function, metabolism, uptake, and transport","volume":"53","author":"Manzetti","year":"2014","journal-title":"Biochemistry"},{"key":"2025061300563974000_vsaf007-B56","doi-asserted-by":"publisher","first-page":"jeb244305","DOI":"10.1242\/jeb.244305","article-title":"Temperature-dependent plasticity mediates heart morphology and thermal performance of cardiac function in juvenile Atlantic Salmon (Salmo salar)","volume":"225","author":"Muir","year":"2022","journal-title":"Journal of Experimental Biology"},{"key":"2025061300563974000_vsaf007-B57","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.jglr.2018.08.009","article-title":"Diet and trophic niche space and overlap of Lake Ontario salmonid species using stable isotopes and stomach contents","volume":"44","author":"Mumby","year":"2018","journal-title":"Journal of Great Lakes Research"},{"key":"2025061300563974000_vsaf007-B58","doi-asserted-by":"publisher","first-page":"bio037853","DOI":"10.1242\/bio.037853","article-title":"Short-term cortisol exposure alters cardiac hypertrophic and non-hypertrophic signalling in a time-dependent manner in Rainbow Trout","volume":"7","author":"N\u00f8rstrud","year":"2018","journal-title":"Biology Open"},{"key":"2025061300563974000_vsaf007-B59","volume-title":"R: A language and environment for statistical computing (Version 4.1.2) [Computer software]","author":"R Core Team","year":"2022"},{"key":"2025061300563974000_vsaf007-B60","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1161\/01.RES.9.4.826","article-title":"Degenerative changes in the cardiovascular system of the spawning Pacific salmon (Oncorhynchus tshawytscha)","volume":"9","author":"Robertson","year":"1961","journal-title":"Circulation Research"},{"key":"2025061300563974000_vsaf007-B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2013.12.029","article-title":"Current aspects of thiamine deficiency on heart function","volume":"98","author":"Roman-Campos","year":"2014","journal-title":"Life Sciences"},{"key":"2025061300563974000_vsaf007-B62","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1152\/japplphysiol.00987.2016","article-title":"Assessment of cardiac fibrosis: A morphometric method comparison for collagen quantification","volume":"122","author":"Schipke","year":"2017","journal-title":"Journal of Applied Physiology"},{"key":"2025061300563974000_vsaf007-B63","doi-asserted-by":"publisher","first-page":"jeb247836","DOI":"10.1242\/jeb.247836","article-title":"Effects of hemodynamic load on cardiac remodeling in fish and mammals: The value of comparative models","volume":"227","author":"Shaftoe","year":"2024","journal-title":"Journal of Experimental Biology"},{"key":"2025061300563974000_vsaf007-B64","doi-asserted-by":"publisher","first-page":"197","DOI":"10.2174\/1566524013363870","article-title":"Molecular mechanisms of thiamine utilization","volume":"1","author":"Singleton","year":"2001","journal-title":"Current Molecular Medicine"},{"key":"2025061300563974000_vsaf007-B65","author":"Sturba","year":"2021"},{"key":"2025061300563974000_vsaf007-B66","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1577\/H03-081.1","article-title":"Thiamine and thiaminase status in forage fish of salmonines from Lake Michigan","volume":"17","author":"Tillitt","year":"2005","journal-title":"Journal of Aquatic Animal Health"},{"key":"2025061300563974000_vsaf007-B67","doi-asserted-by":"publisher","first-page":"H2181","DOI":"10.1152\/ajpheart.00554.2011","article-title":"Oxidative stress and heart failure","volume":"301","author":"Tsutsui","year":"2011","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"2025061300563974000_vsaf007-B68","doi-asserted-by":"publisher","first-page":"coad022","DOI":"10.1093\/conphys\/coad022","article-title":"Population variability in thermal performance of pre-spawning adult Chinook Salmon","volume":"11","author":"Van Wert","year":"2023","journal-title":"Conservation Physiology"},{"key":"2025061300563974000_vsaf007-B69","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1577\/T03-033.1","article-title":"Effects of freshwater and marine growth rates on early maturity in male Coho and Chinook salmon","volume":"133","author":"V\u00f8llestad","year":"2004","journal-title":"Transactions of the American Fisheries Society"},{"key":"2025061300563974000_vsaf007-B70","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3","volume-title":"Ggplot2: Elegant graphics for data analysis","author":"Wickham","year":"2016"},{"key":"2025061300563974000_vsaf007-B71","author":"Wilke","year":"2020"},{"key":"2025061300563974000_vsaf007-B72","doi-asserted-by":"publisher","first-page":"4987","DOI":"10.1002\/ece3.869","article-title":"Sneaker \u201cjack\u201d males outcompete dominant \u201chooknose\u201d males under sperm competition in Chinook Salmon (Oncorhynchus tshawytscha)","volume":"3","author":"Young","year":"2013","journal-title":"Ecology and Evolution"},{"key":"2025061300563974000_vsaf007-B73","doi-asserted-by":"publisher","first-page":"jeb243578","DOI":"10.1242\/jeb.243578","article-title":"It takes time to heal a broken heart: Ventricular plasticity improves heart performance after myocardial infarction in Rainbow Trout, Oncorhynchus mykiss","volume":"224","author":"Zena","year":"2021","journal-title":"Journal of Experimental Biology"}],"container-title":["Journal of Aquatic Animal Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jaah\/article-pdf\/37\/2\/55\/63374310\/vsaf007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jaah\/article-pdf\/37\/2\/55\/63374310\/vsaf007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T04:56:47Z","timestamp":1749790607000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaah\/article\/37\/2\/55\/8151638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":73,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,5,27]]},"published-print":{"date-parts":[[2025,6,13]]}},"URL":"https:\/\/doi.org\/10.1093\/jahafs\/vsaf007","relation":{},"ISSN":["0899-7659","1548-8667"],"issn-type":[{"value":"0899-7659","type":"print"},{"value":"1548-8667","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,5,27]]}}}