{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:04:40Z","timestamp":1784351080634,"version":"3.55.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Requests for urine (UR) and oral fluid (OF) drug testing at our institutions are increasing. However, few studies have assessed the accuracy of each matrix using paired specimens and LC-MS\/MS. We compared OF and UR for detection of cocaine (COC) abuse in addiction medicine-psychiatry (AMP) clinics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We measured COC and benzoylecgonine (BZE) in OF (limit of detection (LOD) 2.0\u2009\u00b5g\/L) and BZE in UR (LOD 5\u2009\u00b5g\/L) by LC-MS\/MS in 258 paired samples, and compared the two matrices when higher UR cutoffs of 25, 50, and 150\u2009\u00b5g\/L were employed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>UR detected more COC abuse than OF at the LOD (5\u2009\u00b5g\/L). BZE was detected in 63 UR specimens and COC and\/or BZE in 40 OF specimens (29 OF+UR+, 11 OF+UR-, 34 OF-UR+). UR creatinine was lower in OF+UR- specimens. COC and BZE were detected in 88% (35\/40) and 75% (30\/40) of OF specimens, respectively. OF was equivalent to UR at detecting COC abuse using a 25\u2009\u00b5g\/L cutoff, and detected more COC abuse than UR using 50 and 150\u2009\u00b5g\/L cutoffs. The ratio of OF COC\/BZE increased with decreasing UR BZE concentrations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We demonstrate that OF detects more COC abuse in an AMP setting when UR BZE cutoffs \u2265 50\u2009\u00b5g\/L are utilized, and that UR creatinine concentrations are significantly lower in specimens positive for COC and\/or BZE in OF and negative for BZE in UR. The presence of only COC in OF and low concentrations of UR BZE likely indicates remote use of COC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jalm\/jfaa032","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T20:10:22Z","timestamp":1581451822000},"page":"935-942","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of Oral Fluid and Urine for Detection of Cocaine Abuse Using Liquid Chromatography with Tandem Mass Spectrometry"],"prefix":"10.1093","volume":"5","author":[{"given":"Stacy E F","family":"Melanson","sequence":"first","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena K","family":"Petrides","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahira","family":"Khaliq","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Griggs","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G","family":"Flood","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"2020101311343828400_jfaa032-B1","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1373\/clinchem.2008.108670","article-title":"Oral fluid testing 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