{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:45:24Z","timestamp":1765295124511},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"BD Life Sciences, Franklin Lakes"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Some therapeutic drugs are unstable during sample storage in gel tubes. BD Vacutainer\u00ae Barricor\u2122 Plasma Blood Collection Tube with nongel separator was compared with plasma gel tubes, BD Vacutainer PST\u2122, PST II, and BD Vacutainer Serum Tube for acetaminophen, salicylate, digoxin, carbamazepine, phenytoin, valproic acid, and vancomycin during sample storage for up to 7\u2009days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Seven hospital sites enrolled 705 participants who were taking at least one selected drug. The study tubes were collected and tested at initial time (0\u2009h), after 48\u2009h of storage at room temperature and on day 7 (after additional 5\u2009days of refrigerated storage). The performance of BD Barricor tube was evaluated for each drug by comparing BD Barricor samples with samples from the other tubes at 0\u2009h from the same participant; stability was evaluated by comparing test results from the same tube at 0\u2009h, 48\u2009h, and 7\u2009days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At 0\u2009h, BD Barricor showed clinically equivalent results for selected therapeutic drugs compared with the other tubes, except phenytoin in BD PST. Phenytoin samples \u226520\u2009\u00b5g\/mL in BD PST had 10\u201312% lower values than samples in BD Barricor. During sample storage, all selected drugs remained stable for 7\u2009days in BD Barricor and in serum aliquots. In BD PST, all drugs remained stable except phenytoin and carbamazepine and in BD PST II except for phenytoin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The BD Barricor Tube is effective for the collection and storage of plasma blood samples for therapeutic drug monitoring without sample aliquoting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jalm\/jfaa033","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T12:08:30Z","timestamp":1581077310000},"page":"671-685","source":"Crossref","is-referenced-by-count":6,"title":["A Multicenter Evaluation of a Nongel Mechanical Separator Plasma Blood Collection Tube for Testing of Selected Therapeutic Drugs"],"prefix":"10.1093","volume":"5","author":[{"given":"Svetlana","family":"Morosyuk","sequence":"first","affiliation":[{"name":"BD, Franklin Lakes, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Berube","sequence":"first","affiliation":[{"name":"BD, Franklin Lakes, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Christenson","sequence":"first","affiliation":[{"name":"School of Medicine, University of Maryland, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H B","family":"Wu","sequence":"first","affiliation":[{"name":"University of California, San Francisco, San Francisco, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Uettwiller-Geiger","sequence":"first","affiliation":[{"name":"John T. Mather Memorial Hospital, Port Jefferson, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Palicka","sequence":"first","affiliation":[{"name":"University Hospital, Hradec Kr\u1f71l\u1f79ve, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Prusa","sequence":"first","affiliation":[{"name":"University Hospital Motol, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Zima","sequence":"first","affiliation":[{"name":"General University Hospital, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Shaw","sequence":"first","affiliation":[{"name":"School of Medicine, University of Maryland, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Plokhoy","sequence":"first","affiliation":[{"name":"BD, Franklin Lakes, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna J","family":"Ahuja","sequence":"first","affiliation":[{"name":"BD, Franklin Lakes, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana K","family":"Stankovic","sequence":"first","affiliation":[{"name":"BD, Franklin Lakes, NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"2020063015040640600_jfaa033-B1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/ajcp\/101.4.456","article-title":"Absorption of therapeutic drugs by barrier gels in serum separator blood collection tubes. 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