{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:19:33Z","timestamp":1761157173170},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study analyzes the clinical characteristics, outcomes, and conditions associated with hyperferritinemia (\u22655000\u2009ng\/mL) in a high-complexity center in Colombia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective and descriptive study was performed between 2011 and 2020, at the Fundaci\u00f3n Valle del Lili, Cali, Colombia, by reviewing medical charts from patients who had serum ferritin measurements equal to or greater than 5000\u2009ng\/mL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found 350 reports of ferritin values \u22655000\u2009ng\/mL, corresponding to 317 patients, with a median ferritin value of 8789 (6001\u201315\u2009373) \u2009ng\/mL. The most frequent etiologies were infection (n\u2009=\u2009198, 56.57%), hematologic disorders (n\u2009=\u2009104, 29.71%), and blood transfusion (n\u2009=\u200998, 28.00%). These last 2 etiologies cooccurred in 37 (10.57%) cases. The main clinical signs accompanying hyperferritinemia were fever in 199 (56.86%) cases, multiorgan involvement in 125 (35.71%), and hepatomegaly in 95 (27.14%) cases. Ninety-four (29.65%) patients died in the hospital, and 11 (3.47%) died within 30\u2009days after medical discharge, mainly due to infection (n\u2009=\u200951, 48.57%). Intrahospital mortality was associated with significantly higher ferritin levels (10\u2009846, IQR: 6425\u201323\u2009459) than survival (8452, IQR: 5980\u201313\u2009932) (P\u2009=\u20090.018).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Hyperferritinemia is related to many underlying causes, with infection being the principal cause in our cohort, followed by hematologic disorders. Additionally, in-hospital mortality was related to higher ferritin levels.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jalm\/jfab076","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T19:12:51Z","timestamp":1624043571000},"page":"1571-1579","source":"Crossref","is-referenced-by-count":1,"title":["Description of the Etiologies, Clinical Characteristics, and Outcomes in Patients with Hyperferritinemia in a Colombian Tertiary Hospital"],"prefix":"10.1093","volume":"6","author":[{"given":"Ingrid","family":"Ruiz-Ordo\u00f1ez","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Puerta-Sarmiento","sequence":"additional","affiliation":[{"name":"Universidad Icesi, Medical School, Cali, Colombia"},{"name":"Fundaci\u00f3n Valle del Lili, Unit of Rheumatology, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Mu\u00f1oz-Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Universidad Icesi, Medical School, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Giraldo-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidad Icesi, Medical School, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Nieto-Aristiz\u00e1bal","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro J","family":"Vivas","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel J","family":"Tob\u00f3n","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Unit of Rheumatology, Cali, Colombia"},{"name":"Universidad Icesi, CIRAT: Centro de Investigaci\u00f3n en Reumatolog\u00eda, Autoinmunidad y Medicina Traslacional, Cali, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"2021110213153645300_jfab076-B1","first-page":"83","article-title":"Hyperferritinemia in autoimmunity","volume":"10","author":"Zandman-Goddard","year":"2008","journal-title":"Isr Med Assoc J"},{"key":"2021110213153645300_jfab076-B2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1039\/C3MT00347G","article-title":"Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells","volume":"6","author":"Kell","year":"2014","journal-title":"Metallomics"},{"key":"2021110213153645300_jfab076-B3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/intimm\/dxx031","article-title":"Hyperferritinemia and inflammation","volume":"29","author":"Kernan","year":"2017","journal-title":"Int Immunol"},{"key":"2021110213153645300_jfab076-B4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/10245332.2018.1488569","article-title":"Hyperferritinemia: causes and significance in a general hospital","volume":"23","author":"Senjo","year":"2018","journal-title":"Hematology"},{"key":"2021110213153645300_jfab076-B5","first-page":"1","article-title":"Hyperferritinemia in critically ill patients","volume":"48","author":"Lachmann","year":"2019","journal-title":"Crit Care Med"},{"key":"2021110213153645300_jfab076-B6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.36384\/01232576.19","article-title":"Estudio del paciente con hiperferritinemia","volume":"23","author":"Campuzano-Maya","year":"2017","journal-title":"Med Lab"},{"key":"2021110213153645300_jfab076-B7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1155\/2013\/493170","article-title":"HFE mutations in Caucasian participants of the Hemochromatosis and Iron Overload Screening study with serum ferritin level &lt;1000 \u03bcg\/L","volume":"27","author":"Adams","year":"2013","journal-title":"Can J Gastroenterol"},{"key":"2021110213153645300_jfab076-B8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/1741-7015-11-185","article-title":"The hyperferritinemic syndrome: macrophage activation syndrome, Still\u2019s disease, septic shock and catastrophic antiphospholipid syndrome","volume":"11","author":"Ros\u00e1rio","year":"2013","journal-title":"BMC Med"},{"key":"2021110213153645300_jfab076-B9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1001\/jama.1994.03510270072043","article-title":"Multiple organ failure syndrome in the 1990s. 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