{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:31:56Z","timestamp":1740180716536,"version":"3.37.3"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Autoimmune endocrine diseases can be thought of as a case of mistaken identity. The immune system mistakenly attacks one\u2019s own cells, as if they were foreign, which typically results in endocrine gland hypofunction and inadequate hormone production. Type 1 diabetes mellitus and autoimmune thyroid disorders (Hashimoto and Graves diseases) are the most common autoimmune endocrine disorders, while conditions such as Addison disease are encountered less frequently. Autoantibody production can precede clinical presentation, and their measurement may aid verification of an autoimmune process and guide appropriate treatment modalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Content<\/jats:title>\n                  <jats:p>In this review, we discuss type 1 diabetes mellitus, autoimmune thyroid disorders, and Addison disease, emphasizing their associated autoantibodies and methods for clinical detection. We will also discuss efforts to standardize measurement of autoantibodies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Autoimmune endocrine disease progression may take months to years and detection of associated autoantibodies may precede clinical onset of disease. Although detection of autoantibodies is not necessary for diagnosis, they may be useful to verify an autoimmune process.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jalm\/jfab128","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T19:56:01Z","timestamp":1633118161000},"page":"206-220","source":"Crossref","is-referenced-by-count":4,"title":["Mistaken Identity: The Role of Autoantibodies in Endocrine Disease"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-2923","authenticated-orcid":false,"given":"Heather A","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemant R","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joely A","family":"Straseski","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"issue":"6","key":"2022010916493931200_jfab128-B1","doi-asserted-by":"crossref","first-page":"a006957","DOI":"10.1101\/cshperspect.a006957","article-title":"T-cell tolerance: central and peripheral","volume":"4","author":"Xing","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2022010916493931200_jfab128-B2","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nri1939","article-title":"Receptor editing in lymphocyte development and central tolerance","volume":"6","author":"Nemazee","year":"2006","journal-title":"Nat Rev 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