{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:30:57Z","timestamp":1740180657124,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:00:00Z","timestamp":1674259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Phlebotomy can be an uncomfortable and even painful experience that increases in likelihood in patients who require frequent blood draws, such as those with cancer. The 25-gauge BD Vacutainer\u00ae UltraTouch\u2122 Push Button Blood Collection Set has a smaller outer bore needle size and unique bevel configuration, which in theory should reduce pain associated with phlebotomy. Smaller needles typically cause less pain, however, they have a higher incidence of compromising the specimen integrity. Innovative engineering allows this particular needle to maintain a larger inner bore size similar to a standard 23-gauge needle. This study compares pain and specimen integrity between this novel device and a standard 23-gauge needle.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Two cohorts of 190 patients each had phlebotomy performed with either needle. Pain experienced was assessed by patient surveys, rating pain from 0 (low) to 10 (high). Sample integrity was assessed by determining the hemolysis index (Abbott Architect c8000).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>No statistically significant difference in median pain scores was observed between the 2 cohorts, P-value: 0.068. The 23-gauge cohort more frequently reported 3+ pain than the 25-gauge cohort, 14\/190 vs 5\/190. Pain scoring 1 and 2 was more frequent in the 25-gauge cohort, 84\/190 vs 54\/190. Pain scores of 0 were more frequent in the 23-gauge cohort, 122\/190 vs 101\/190. This stratification is statistically significant, P-value: 0.003. The 25-gauge needle showed no increase in hemolysis rates, P-value: 0.5.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Sample integrity was identical between both needles. The 25-gauge needle resulted in less 3+ pain, while pain scoring 1 and 2 was more frequent in the 25-gauge cohort.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jalm\/jfac129","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T06:10:03Z","timestamp":1674281403000},"page":"264-271","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of a Novel Thin-Walled 25-gauge Needle Push Button Blood Collection Set to a Standard 23-gauge Needle in a Cancer Patient Population"],"prefix":"10.1093","volume":"8","author":[{"given":"Daniel","family":"Kirchhoff","sequence":"first","affiliation":[{"name":"Clinical Chemistry Service, Department of Pathology, Molecular and Cell-Based Medicine , The Mount Sinai Hospital, New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1644-4090","authenticated-orcid":false,"given":"Raymond","family":"Baser","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kwong","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel I","family":"McCash","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center , New York, NY , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,21]]},"reference":[{"key":"2023050412164586500_jfac129-B1","doi-asserted-by":"crossref","first-page":"E403","DOI":"10.1503\/cmaj.101341","article-title":"Epidemiology and management of painful procedures in children in Canadian hospitals","volume":"183","author":"Stevens","year":"2011","journal-title":"Can Med Assoc J"},{"key":"2023050412164586500_jfac129-B2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1542\/peds.90.1.87","article-title":"The occurrence of high levels of acute behavioral distress in children and adolescents undergoing routine venipunctures","volume":"90","author":"Humphrey","year":"1992","journal-title":"Pediatrics"},{"key":"2023050412164586500_jfac129-B3","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.janxdis.2006.01.004","article-title":"Fear of needles and vasovagal reactions among phlebotomy patients","volume":"20","author":"Deacon","year":"2006","journal-title":"J Anxiety Disord"},{"key":"2023050412164586500_jfac129-B4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/adc.2006.097246","article-title":"Analgesic effect of watching TV during venipuncture","volume":"91","author":"Bellieni","year":"2006","journal-title":"Arch Dis Child"},{"key":"2023050412164586500_jfac129-B5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.omsc.2015.05.004","article-title":"Topical refrigerant spray for pediatric venipuncture for outpatient surgery","volume":"1","author":"Schlieve","year":"2015","journal-title":"Oral Maxillofac Surg Cases"},{"key":"2023050412164586500_jfac129-B6","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1542\/peds.109.6.1093","article-title":"A clinical study to evaluate the efficacy of ELA-Max (4% liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children","volume":"109","author":"Eichenfield","year":"2002","journal-title":"Pediatrics"},{"key":"2023050412164586500_jfac129-B7","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1177\/193229680700100517","article-title":"Does needle size matter?","volume":"1","author":"Gill","year":"2007","journal-title":"J Diabetes Sci Technol"},{"key":"2023050412164586500_jfac129-B8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139432","article-title":"A randomized controlled trial on the effect of needle gauge on the pain and anxiety experienced during radial arterial puncture","volume":"10","author":"Patout","year":"2015","journal-title":"PLoS One"},{"key":"2023050412164586500_jfac129-B9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jen.2005.05.004","article-title":"Factors affecting hemolysis rates in blood samples drawn from newly placed iv sites in the emergency department","volume":"31","author":"Dugan","year":"2005","journal-title":"J Emerg Nurs"},{"key":"2023050412164586500_jfac129-B10","first-page":"7","article-title":"Improving Quality at the Preanalytical Phase of Blood Sampling: Literature Review","volume":"2","author":"Makitalo","year":"2013","journal-title":"IJBLS"},{"key":"2023050412164586500_jfac129-B11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cca.2016.05.003","article-title":"Causes and impact of specimen rejection in a clinical chemistry laboratory","volume":"458","author":"Cao","year":"2016","journal-title":"Clin Chim Acta"},{"key":"2023050412164586500_jfac129-B12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1515\/CCLM.2006.172","article-title":"Influence of the needle bore size used for collecting venous blood samples on routine clinical chemistry testing","volume":"44","author":"Lippi","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"2023050412164586500_jfac129-B13"},{"key":"2023050412164586500_jfac129-B14","first-page":"100","article-title":"A retractable winged steel (butterfly) needle performance improvement project","volume":"35","author":"Hotaling","year":"2009","journal-title":"Jt Comm J Qual Patient Saf"},{"key":"2023050412164586500_jfac129-B15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cca.2019.10.019","article-title":"Evaluation of an improved small gauge needle for venipuncture in children with difficult venous access: impact on sample quality, phlebotomist satisfaction and patient pain perception","volume":"500","author":"Padoan","year":"2020","journal-title":"Clin Chim Acta"},{"key":"2023050412164586500_jfac129-B16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/emermed-2014-203600","article-title":"ABG needle study: a randomised control study comparing 23G versus 25G needle success and pain scores","volume":"32","author":"Yee","year":"2015","journal-title":"Emerg Med J"},{"key":"2023050412164586500_jfac129-B17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1373\/jalm.2017.023564","article-title":"Evaluation of pain and specimen quality by use of a novel 25-gauge blood collection set with ultra-thin wall cannula and 5-bevel tip design","volume":"2","author":"Mouser","year":"2019","journal-title":"J Appl Lab Med"}],"container-title":["The Journal of Applied Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jalm\/article-pdf\/8\/2\/264\/50194634\/jfac129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jalm\/article-pdf\/8\/2\/264\/50194634\/jfac129.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T13:01:33Z","timestamp":1683205293000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jalm\/article\/8\/2\/264\/6995008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,21]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,1,21]]},"published-print":{"date-parts":[[2023,3,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jalm\/jfac129","relation":{},"ISSN":["2475-7241"],"issn-type":[{"type":"electronic","value":"2475-7241"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2023,1,21]]}}}