{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:54:27Z","timestamp":1780102467869,"version":"3.54.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Institute of Clinical and Experimental Pathology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Detection of anticyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factors (RF) in sera support the diagnosis of rheumatoid arthritis (RA); however, these markers are not detected in about 20% of RA patients. More recently, antibodies against carbamylated proteins (anti-CarP) have emerged with implications for preclinical RA diagnosis. The objective of this study was to assess the clinical performance of anti-CarP and correlate with disease severity in routine clinical practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective chart review of 331 subjects submitted for RA panel serology: 136 clinically defined RA-positive and 195 RA-negative patients. Fifty additional individuals were recruited for healthy controls. Patients\u2019 sera were tested for anti-CCP, anti-CarP, and RF antibodies. Clinical performance characteristics were evaluated for anti-CarP individually and in combination with anti-CCP and RF. Documented erosions and synovitis were correlated with anti-CarP positivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Anti-CarP had a clinical sensitivity and specificity of 27% and 94%, respectively, for established RA. This sensitivity was lower than anti-CCP (79%) and RF (85%). The specificity of anti-CarP was similar to anti-CCP (93%) and higher than RF (69%). Anti-CarP in combination with anti-CCP and RF increased specificity (100%) but decreased sensitivity (21%). There was no correlation of anti-CarP positivity with presence of bone erosions; however, there was an increase in anti-CarP positivity among patients with synovitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Anti-CarP demonstrates high specificity in diagnosis of established RA but lacks clinical sensitivity. In combination, anti-CarP does not improve clinical performance of anti-CCP and RF but may be useful in anti-CCP negative patients and in identifying patients with more active disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jalm\/jfad088","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T22:56:38Z","timestamp":1701298598000},"page":"251-261","source":"Crossref","is-referenced-by-count":3,"title":["Performance of Anti-Carbamylated Protein Antibody Testing in the Routine Evaluation of Rheumatoid Arthritis from a Single Center"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-2923","authenticated-orcid":false,"given":"Heather A","family":"Nelson","sequence":"first","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology , Salt Lake City, UT , United States"},{"name":"Department of Pathology, University of Utah School of Medicine , Salt Lake City, UT , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille L","family":"Novis","sequence":"additional","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology , Salt Lake City, UT , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Lebiedz-Odrobina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Utah and George E Whalen Department of Veteran Affairs Medical Center , Salt Lake City, UT , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalakshmi","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology , Salt Lake City, UT , United States"},{"name":"Department of Pathology, University of Utah School of Medicine , Salt Lake City, UT , United 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