{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:30:53Z","timestamp":1740180653497,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Growth differentiation factor-15 (GDF-15) has been shown to be associated with adverse clinical outcomes in patients after an acute coronary syndrome when measured soon after an event. Although dynamic in the acute phase after myocardial injury, GDF-15 has been shown to remain stable during convalescence. In this study, we aimed to assess the value of GDF-15 as a long-term prognostic marker for clinical outcomes when measured in the convalescent phase following an acute coronary syndrome.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n GDF-15 concentrations were measured in 1945 patients who were recruited between 2002 and 2009 to the Coronary Disease Cohort Study. For this analysis, follow-up was curtailed at 10 years and association of GDF-15 with all-cause death, cardiovascular death, recurrent myocardial infarction, and heart failure hospitalizations were assessed with multivariate Cox proportional hazard regression analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n After 10 years of follow-up, there were 648 deaths (348 from cardiovascular causes), 500 admissions for myocardial infarction, and 436 for heart failure. Four-month convalescent GDF-15 demonstrated a robust independent association with all endpoints, which remained after adjustment for Global Registry of Acute Coronary Events score and other convalescent biomarkers. When compared to the lowest quartile of GDF-15 concentrations, those in the highest quartile had a 3-fold increased risk of all-cause death.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Convalescent plasma GDF-15 is a strong and independent predictor of 10-year all-cause death, cardiovascular death, recurrent myocardial infarction, and heart failure admission following an acute coronary syndrome.<\/jats:p>\n <\/jats:sec>\n \n Australian New Zealand Clinical Trials Registry Trial ID<\/jats:title>\n ACTRN12605000431628.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/jalm\/jfae032","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T18:12:26Z","timestamp":1713463946000},"page":"672-683","source":"Crossref","is-referenced-by-count":0,"title":["Convalescent Growth Differentiation Factor-15 and Long-Term Outcomes after an Acute Coronary Syndrome"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-5355","authenticated-orcid":false,"given":"Charlotte E","family":"Greer","sequence":"first","affiliation":[{"name":"Christchurch Heart Institute, University of Otago , Christchurch , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Chew-Harris","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago , Christchurch , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip D","family":"Adamson","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago , Christchurch , New Zealand"},{"name":"British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh , Edinburgh , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J","family":"Pemberton","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago , Christchurch , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-0344","authenticated-orcid":false,"given":"John W","family":"Pickering","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago , Christchurch , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna P","family":"Pilbrow","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago , Christchurch , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris M","family":"Frampton","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago , Christchurch , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W","family":"Troughton","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago , Christchurch , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N","family":"Doughty","sequence":"additional","affiliation":[{"name":"Greenlane Cardiovascular Service, Te Toka Tumai Auckland Hospital , Auckland , New Zealand"},{"name":"Heart Health Research Group, Department of Medicine, University of Auckland , Auckland , New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Mark","family":"Richards","sequence":"additional","affiliation":[{"name":"Christchurch Heart Institute, University of Otago , Christchurch , New Zealand"},{"name":"Cardiovascular Research Institute, National University of Singapore , Singapore , Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"2024070115211861600_jfae032-B1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1161\/CIRCOUTCOMES.111.964700","article-title":"Long-term survival and recurrence after acute myocardial infarction in England, 2004 to 2010","volume":"5","author":"Smolina","year":"2012","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2024070115211861600_jfae032-B2","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1093\/eurheartj\/ehq326","article-title":"Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK\u2013Belgian Study)","volume":"31","author":"Fox","year":"2010","journal-title":"Eur Heart J"},{"key":"2024070115211861600_jfae032-B3","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)","volume":"42","author":"Collet","year":"2020","journal-title":"Eur Heart J"},{"key":"2024070115211861600_jfae032-B4","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.3389\/fphys.2018.01712","article-title":"GDF15 and growth control","volume":"9","author":"Emmerson","year":"2018","journal-title":"Front Physiol"},{"key":"2024070115211861600_jfae032-B5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/eurheartj\/ehac577","article-title":"Growth differentiation factor 15 and cardiovascular risk: individual patient meta-analysis","volume":"44","author":"Kato","year":"2023","journal-title":"Eur Heart J"},{"key":"2024070115211861600_jfae032-B6","first-page":"1346","article-title":"Growth-differentiation factor-15 predicts adverse cardiac events in patients with acute coronary syndrome: a meta-analysis","volume":"37","author":"Wang","year":"2019","journal-title":"Am J Emerg Med"},{"key":"2024070115211861600_jfae032-B7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1373\/clinchem.2016.255174","article-title":"Growth differentiation factor 15 as a biomarker in cardiovascular disease","volume":"63","author":"Wollert","year":"2017","journal-title":"Clin Chem"},{"key":"2024070115211861600_jfae032-B8","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ahj.2013.09.013","article-title":"Growth differentiation factor 15 and cardiovascular events in patients with stable ischemic heart disease (The Heart and Soul Study)","volume":"167","author":"Schopfer","year":"2014","journal-title":"Am Heart J"},{"key":"2024070115211861600_jfae032-B9","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/eurheartj\/ehr444","article-title":"Adjustment of the GRACE score by growth differentiation factor 15 enables a more accurate appreciation of risk in non-ST-elevation acute coronary syndrome","volume":"33","author":"Widera","year":"2012","journal-title":"Eur Heart J"},{"key":"2024070115211861600_jfae032-B10","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1001\/jama.291.22.2727","article-title":"A validated prediction model for all forms of acute coronary syndrome: Estimating the risk of 6-month postdischarge death in an international registry","volume":"291","author":"Eagle","year":"2004","journal-title":"JAMA"},{"key":"2024070115211861600_jfae032-B11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.amjcard.2019.03.049","article-title":"Temporal pattern of growth differentiation factor-15 protein after acute coronary syndrome (from the BIOMArCS study)","volume":"124","author":"Buljubasic","year":"2019","journal-title":"Am J Cardiol"},{"key":"2024070115211861600_jfae032-B12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/CIRCGENETICS.109.877456","article-title":"Growth-differentiation factor-15 for long-term risk prediction in patients stabilized after an episode of non\u2013ST-segment\u2013elevation acute coronary syndrome","volume":"3","author":"Eggers","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"2024070115211861600_jfae032-B13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/01.RES.0000202805.73038.48","article-title":"The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia\/reperfusion injury","volume":"98","author":"Kempf","year":"2006","journal-title":"Circ Res"},{"key":"2024070115211861600_jfae032-B14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1373\/clinchem.2016.257816","article-title":"C-type natriuretic peptides in coronary disease","volume":"63","author":"Prickett","year":"2017","journal-title":"Clin Chem"},{"key":"2024070115211861600_jfae032-B15","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1136\/heartjnl-2019-315084","article-title":"Convalescent troponin and cardiovascular death following acute coronary syndrome","volume":"105","author":"Adamson","year":"2019","journal-title":"Heart"},{"key":"2024070115211861600_jfae032-B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2018.06.004","article-title":"Guidelines for performing a comprehensive transthoracic echocardiographic examination in adults: recommendations from the American society of echocardiography","volume":"32","author":"Mitchell","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"key":"2024070115211861600_jfae032-B17","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.ahj.2008.07.030","article-title":"Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006","volume":"156","author":"Rogers","year":"2008","journal-title":"Am Heart J"},{"key":"2024070115211861600_jfae032-B18","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1001\/archinte.163.19.2345","article-title":"Predictors of hospital mortality in the global registry of acute coronary events","volume":"163","author":"Granger","year":"2003","journal-title":"Arch Intern Med"},{"key":"2024070115211861600_jfae032-B19","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/eurheartj\/ehs215","article-title":"ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"33","author":"Members ATF","year":"2012","journal-title":"Eur Heart J"},{"key":"2024070115211861600_jfae032-B20","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ejhf.117","article-title":"Growth-differentiation factor 15 and osteoprotegerin in acute myocardial infarction complicated by cardiogenic shock: a biomarker substudy of the IABP-SHOCK II-trial","volume":"16","author":"Fuernau","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"2024070115211861600_jfae032-B21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/s12882-021-02558-w","article-title":"Growth differentiation factor-15 and incident chronic kidney disease: a population-based cohort study","volume":"22","author":"Bao","year":"2021","journal-title":"BMC Nephrol"},{"key":"2024070115211861600_jfae032-B22","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/ALN.0000000000004539","article-title":"Association of preoperative growth differentiation factor-15 concentrations and postoperative cardiovascular events after major noncardiac surgery","volume":"138","author":"Duceppe","year":"2023","journal-title":"Anesthesiology"},{"key":"2024070115211861600_jfae032-B23","first-page":"100046","article-title":"Growth differentiation factor-15, a novel systemic biomarker of oxidative stress, inflammation, and cellular aging: potential role in cardiovascular diseases","volume":"9","author":"di Candia","year":"2021","journal-title":"Am Heart J Plus"},{"key":"2024070115211861600_jfae032-B24","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1136\/thoraxjnl-2019-213621","article-title":"Growth differentiation factor-15 as a biomarker of strength and recovery in survivors of acute respiratory failure","volume":"74","author":"Rosenberg","year":"2019","journal-title":"Thorax"},{"key":"2024070115211861600_jfae032-B25","doi-asserted-by":"crossref","first-page":"e005594","DOI":"10.1161\/CIRCINTERVENTIONS.117.005594","article-title":"GDF-15 (growth differentiation factor 15) is associated with lack of ventricular recovery and mortality after transcatheter aortic valve replacement","volume":"10","author":"Kim","year":"2017","journal-title":"Circ Cardiovasc Interv"}],"container-title":["The Journal of Applied Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jalm\/article-pdf\/9\/4\/672\/58379353\/jfae032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jalm\/article-pdf\/9\/4\/672\/58379353\/jfae032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T18:21:52Z","timestamp":1719858112000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jalm\/article\/9\/4\/672\/7651012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4,18]]},"published-print":{"date-parts":[[2024,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jalm\/jfae032","relation":{},"ISSN":["2475-7241"],"issn-type":[{"type":"electronic","value":"2475-7241"}],"subject":[],"published-other":{"date-parts":[[2024,7]]},"published":{"date-parts":[[2024,4,18]]}}}