{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:20:11Z","timestamp":1725409211102},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Mild traumatic brain injury (mTBI) is defined as a Glascow Coma Score of between 13 and 15. The diagnosis and rule out of individuals suffering from mTBI on an acute basis is imperfect and involves subjective measures. Serum biomarkers that exhibit narrow within-individual biological variation can be used for the early rule-out of mTBI, when baseline levels are compared during health.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This is a descriptive study that applies published biological variation data of serum mTBI biomarkers for early rule out of sports-related injury.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Laboratory tests such as glial fibrillary acidic protein, fatty acid binding protein 7, and phosphorylated protein enriched in astrocytes have low within-individual variances and are potential candidates. Aldolase C also rises early in blood but the biological variation is of this marker is currently unknown.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The use of blood-based biomarkers, measured in real time using point-of-care testing devices when compared to a pre-competition baseline instead of a population-based reference interval, can provide early rule out of mTBI, and possibly enable on-field evaluations and a medical decision for a return to competition.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/jalm\/jfae070","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T03:49:05Z","timestamp":1720410545000},"page":"1057-1063","source":"Crossref","is-referenced-by-count":0,"title":["On-Field Rule Out of Mild Traumatic Brain Injury: Can Blood-Based Biomarker Testing Change Outcome of Major Sporting Events?"],"prefix":"10.1093","volume":"9","author":[{"given":"Alan H B","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, University of California , San Francisco, CA , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W Franklin","family":"Peacock","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Baylor College of Medicine , Houston, TX , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"2024090311500118200_jfae070-B1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.15585\/mmwr.mm6927a4","article-title":"Trends in emergency department visits for contact sports-related traumatic brain injuries among children- United States, 2002\u20132018","volume":"68","author":"Waltzman","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"volume-title":"Biomarkers of traumatic brain injury","year":"2020","author":"Wu","key":"2024090311500118200_jfae070-B2"},{"key":"2024090311500118200_jfae070-B3","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S1474-4422(18)30231-X","article-title":"Serum GFAP and UCH-1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study","volume":"17","author":"Bazarian","year":"2018","journal-title":"Lancet Neurol"},{"key":"2024090311500118200_jfae070-B4","volume-title":"Defining, establishing, and verifying reference intervals in the clinical laboratory; approved guideline, EP-28-A3c","author":"Horowitz","year":"2008","edition":"3rd Ed"},{"key":"2024090311500118200_jfae070-B5","first-page":"104","volume-title":"Biological variation: from principles to practice","author":"Fraser","year":"2001"},{"key":"2024090311500118200_jfae070-B6","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1016\/j.neuchi.2022.06.003","article-title":"Early dynamics of glial fibrillary acidic protein and extracellular DNA in plasma of mice after closed head injury","volume":"68","author":"Kmetov","year":"2002","journal-title":"Neurochirurgie"},{"key":"2024090311500118200_jfae070-B7","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1515\/cclm-2022-0480","article-title":"Short-term biological variation of serum glial fibrillary acidic protein","volume":"60","author":"Christenson","year":"2022","journal-title":"Clin Chem Lab Med"},{"key":"2024090311500118200_jfae070-B8","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1373\/clinchem.2018.292169","article-title":"Providing correct estimates of biological variation-not an easy task. The example of S100-\u03b2 protein and neuron-specific enolase","volume":"64","author":"Carobene","year":"2018","journal-title":"Clin Chem"},{"key":"2024090311500118200_jfae070-B9","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1515\/cclm-2020-1276","article-title":"Biological variation of serum neurofilament light chain","volume":"60","author":"Hviid","year":"2022","journal-title":"Clin Chem Lab Med"},{"key":"2024090311500118200_jfae070-B10","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/clinchem\/hvac194","article-title":"Using biomarkers for traumatic brain injury: are there lessons that can be learned from implementing cardiac troponin?","volume":"69","author":"Wu","year":"2023","journal-title":"Clin Chem"},{"key":"2024090311500118200_jfae070-B11","doi-asserted-by":"crossref","first-page":"e2133","DOI":"10.1212\/WNL.0000000000006617","article-title":"Concussion BASICS III: serum biomarker changes following sport-related concussion","volume":"91","author":"Asken","year":"2018","journal-title":"Neurology"},{"key":"2024090311500118200_jfae070-B12","doi-asserted-by":"crossref","first-page":"e2013191","DOI":"10.1001\/jamanetworkopen.2020.13191","article-title":"Plasma biomarker concentrations associated with return to sport following sport-related concussion in collegiate athletes\u2014a Concussion Assessment, Research, and Education (CARE) Consortium study","volume":"3","author":"Pattinson","year":"2020","journal-title":"JAMA Netw Open"},{"key":"2024090311500118200_jfae070-B13","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1177\/0271678X17724681","article-title":"New astroglial injury-defined biomarkers for neurotrauma assessment","volume":"37","author":"Halford","year":"2017","journal-title":"J Cerebral Blood Flow Metab"},{"key":"2024090311500118200_jfae070-B14","first-page":"33","article-title":"Aldolase C profiling in serum after mild traumatic brain injury: a prospective cohort study","volume":"47","author":"Haddadi","year":"2022","journal-title":"Iran J Med Sci"}],"container-title":["The Journal of Applied Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jalm\/article-pdf\/9\/5\/1057\/59001257\/jfae070.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jalm\/article-pdf\/9\/5\/1057\/59001257\/jfae070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T13:49:27Z","timestamp":1725371367000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jalm\/article\/9\/5\/1057\/7708847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,8]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,7,8]]},"published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jalm\/jfae070","relation":{},"ISSN":["2475-7241"],"issn-type":[{"type":"electronic","value":"2475-7241"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,7,8]]}}}