{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:22:04Z","timestamp":1758892924623,"version":"3.37.3"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Sex- and population-specific 99th percentiles of high-sensitivity cardiac troponin (hs-cTn) are recommended in guidelines although the evidence for a clinical utility is sparse. The DANSPOT trial will investigate the clinical effect of sex- and population-specific 99th percentiles of cTn. We report the 99th percentiles derived from this trial and their dependency on kidney function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used samples from healthy Danish blood donors and measured hemoglobin A1c, N-terminal pro-brain natriuretic peptide and creatinine, and calculated an estimated glomerular filtration rate (eGFR). We compared 2 cutoffs for the eGFR of healthy participants (60 vs 90\u2005mL\/min\/1.73\u2005m2). The cTn assays investigated were Siemens Atellica and Dimension Vista hs-cTnI, Abbott hs-cTnI, and Roche hs-cTnT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2287 participants were sampled, of which 71 (3.1%) were excluded due to a history of heart disease (n = 4), insufficient material (n = 7), or a screening biomarker (n = 60). Of the remaining 2216 participants, 1325 (59.8%) had an eGFR \u226590\u2005mL\/min\/1.73\u2005m2. Compared to a cutoff of 60 mL\/min\/1.73\u2005m2 for eGFR, using 90\u2005mL\/min\/1.73\u2005m2 resulted in lower 99th percentiles for females; Siemens Vista (46 vs 70\u2005ng\/L), Abbott (14 vs 18\u2005ng\/L), and Roche cTnT (10 vs 13\u2005ng\/L), and decreased the number of measurements above the manufacturers\u2019 99th percentiles for all assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We present reference values for 4 cTn assays for eGFR cutoffs of 60 and 90\u2005mL\/min\/1.73\u2005m2. These cutoffs differ based on the eGFR threshold for inclusion indicating that any chosen cutoff is also valuable with moderately reduced kidney function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jalm\/jfae088","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T12:24:40Z","timestamp":1724934280000},"page":"901-912","source":"Crossref","is-referenced-by-count":4,"title":["Sex and Population-Specific 99th Percentiles of Troponin for Myocardial Infarction in the Danish Population (DANSPOT)"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-6268","authenticated-orcid":false,"given":"Rasmus Bo","family":"Hasselbalch","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoline","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Strandkj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thilde Olivia","family":"Kock","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev and Gentofte , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6807-8347","authenticated-orcid":false,"given":"Theis","family":"Lange","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Department of Public Health, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisse Rye","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Immunology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janna","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit H\u00f8rup","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole Birger Vesterager","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Immunology, Zealand University Hospital , K\u00f8ge ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Vakur","family":"Bor","sequence":"additional","affiliation":[{"name":"South West Jutland Hospital, Department of Clinical Biochemistry , Esbjerg 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