{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:17:53Z","timestamp":1791605873987,"version":"4.3.4"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cardiac troponin is the gold-standard biomarker for the evaluation of patients with suspected acute myocardial infarction (MI). Improvements in assay technology have led to high-sensitivity cardiac troponin assays that, when incorporated into accelerated diagnostic pathways, may rapidly diagnose or exclude acute MI more efficiently than conventional troponin assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Content<\/jats:title>\n                  <jats:p>In this narrative review, we provide practical suggestions for implementing high-sensitivity cardiac troponin assays, review accelerated diagnostic pathways incorporating these assays, and review the impact of these assays on resource utilization and cost-effectiveness in relation to the evaluation of individuals with possible acute MI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>An increasing number of hospitals are transitioning to high-sensitivity cardiac troponin assays. This narrative review provides an overview of the potential benefits of this transition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jalm\/jfae161","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T04:18:06Z","timestamp":1737865086000},"page":"710-730","source":"Crossref","is-referenced-by-count":5,"title":["High-Sensitivity Cardiac Troponin Assays: From Implementation to Resource Utilization and Cost Effectiveness"],"prefix":"10.1093","volume":"10","author":[{"given":"Hong-Kee","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Endeavor Health , Evanston, IL ,","place":["United States"]},{"name":"Department of Pathology, University of Chicago Pritzker School of Medicine , Chicago, IL ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cian P","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Massachusetts General Hospital, Harvard Medical School , Boston, MA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-3959","authenticated-orcid":false,"given":"Allan S","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Mayo Clinic , Rochester, MN ,","place":["United States"]},{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, MN ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-8130","authenticated-orcid":false,"given":"Richard","family":"Body","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Manchester , Manchester ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Manchester , Manchester ,","place":["United Kingdom"]},{"name":"Emergency Medical Services Department, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences , Riyadh ,","place":["Saudi Arabia"]},{"name":"King Abdullah International Medical Research Center , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4800-2972","authenticated-orcid":false,"given":"Yader","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute, Abbott Northwestern Hospital , Minneapolis, MN ,","place":["United States"]},{"name":"Center for Coronary Artery Disease, Minneapolis Heart Institute Foundation , Minneapolis, MN ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-1798","authenticated-orcid":false,"suffix":"Jr.","given":"James 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