{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:06:10Z","timestamp":1791144370933,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Urine sediment analysis is a cornerstone of diagnostic testing. This study evaluates FUS-3000 Plus, an automated urine sediment analyzer using advanced imaging and artificial intelligence, to assess its technical performance and diagnostic accuracy for routine clinical use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study analyzed 98 urine samples for chemical parameters (pH, protein, blood, leukocyte esterase, and nitrite) and 76 samples for particle analysis (red blood cells [RBCs], white blood cells, epithelial cells, crystals, bacteria) by both FUS-3000 Plus and sediMAX\u2122, the current laboratory analyzer in use. Additionally, 139 samples were tested for glucosuria and proteinuria, with results compared to the Cobas C702. Carry-over, precision, and linearity were assessed by internal quality controls in accordance with Clinical and Laboratory Standards Institute protocols. Accuracy was further evaluated using external quality controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>FUS-3000 Plus demonstrated strong agreement with sediMAX for nitrites, protein, and leukocyte esterase (kappa values &amp;gt;0.5) and correlated well with the Cobas C702 for glucosuria and proteinuria. However, discrepancies were observed in glucosuria detection, with some samples yielding inaccurate results even during external quality control assessments. A carry-over effect for RBCs required a rinse step after highly concentrated samples.<\/jats:p>\n                    <jats:p>Precision was acceptable (CV: 3%\u201311%), and Bland\u2013Altman plots showed strong agreement for formed elements (correlation &amp;gt;0.95). However, the analyzer had reduced accuracy in bacteriuria detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FUS-3000 Plus is a reliable tool for routine urinalysis, excelling in particle classification. However, improvements are needed in bacteriuria detection and minimizing carry-over effects. Future research should explore its ability to identify additional cellular elements and its diagnostic utility in diverse clinical populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jalm\/jfaf111","type":"journal-article","created":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T12:15:02Z","timestamp":1753013702000},"page":"1453-1465","source":"Crossref","is-referenced-by-count":1,"title":["First Laboratory Evaluation of FUS-3000 Plus: A New-Generation Urine Analyzer"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9065-393X","authenticated-orcid":false,"given":"Yasmine","family":"Nezzar","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Catholic University of Louvain , Brussels ,","place":["Belgium"]},{"name":"Department of Medical Biology, CHR Haute Senne , Soignies 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