{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:12:28Z","timestamp":1776903148325,"version":"3.51.2"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":61,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the emergency setting, acute abdominal pain is a diagnostic challenge. We evaluated the diagnostic value of selected inflammatory and stress biomarkers to identify surgical emergency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients presenting to the emergency department (ED) with acute abdominal pain were included in this prospective observational study. Copeptin, cortisol, procalcitonin, and interleukin 6 (IL-6) were measured upon presentation and at 4 h, in addition to C-reactive protein (CRP), and leukocyte and neutrophil cell counts. At 2 weeks, follow-up was performed by telephone interview.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 304 patients included, 46 (15%) patients had a surgical emergency and 87 (29%) a medical emergency. On admission, CRP, procalcitonin, and leukocyte and neutrophil cell counts were higher in patients with a surgical emergency (P = 0.024, P = 0.009, P = 0.0032, and P &amp;lt; 0.0001, respectively) and medical emergency (all P &amp;lt; 0.001) as compared to patients without emergency. Area under the receiver operating characteristic curve (AUC) was to predict surgical emergency and were good for leukocyte (AUC 0.75, 95% CI, 0.66\u20130.84) and neutrophil cell count (AUC 0.75, 95%, CI 0.66\u20130.84), mediocre for CRP (AUC 0.64, 95% CI, 0.55\u20130.73) and procalcitonin (AUC 0.62, 95%CI 0.45\u20130.75), and not useful for IL-6, copeptin, or cortisol. A recursive partitioning prediction model yielded CRP as the most relevant biomarker to predict surgical emergency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The stress biomarkers copeptin and cortisol were not useful for identifying surgical emergency. Among the tested biomarkers, initial leukocyte and neutrophil cell counts, CRP and procalcitonin, and IL-6 at Hour 4, performed similarly to identify surgical emergency in acute abdomen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ClinicalTrials.gov Registration Number<\/jats:title>\n                    <jats:p>NCT02399150<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jalm\/jfaf137","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T11:53:00Z","timestamp":1756986780000},"page":"1537-1551","source":"Crossref","is-referenced-by-count":1,"title":["Biomarkers for Detecting Surgical Emergency in Acute Abdomen\u2014A Prospective Observational Study"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0487-5587","authenticated-orcid":false,"given":"Claudine A","family":"Blum","sequence":"first","affiliation":[{"name":"Service d\u2019Accueil des Urgences, GH Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Faculty of Medicine, University of Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-0792","authenticated-orcid":false,"given":"Matthieu","family":"Faron","sequence":"additional","affiliation":[{"name":"Service de Chirurgie G\u00e9n\u00e9rale, Visc\u00e9rale, Endocrinienne, GH Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"D\u00e9partement de Biostatistiques et \u00e9pid\u00e9miologie, unit\u00e9 INSERM 1018 CESP Equipe Oncostat , Villejuif ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0491-5289","authenticated-orcid":false,"given":"Anne Laure","family":"Paquet","sequence":"additional","affiliation":[{"name":"Service d\u2019Accueil des Urgences, GH Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La\u00ebtitia","family":"Velly","sequence":"additional","affiliation":[{"name":"Service d\u2019Accueil des Urgences, GH Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Facult\u00e9 de M\u00e9decine, Sorbonnes Universit\u00e9s, GRC-14 BIOSFAST , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-9847","authenticated-orcid":false,"given":"Christine","family":"Brochet","sequence":"additional","affiliation":[{"name":"Service de Biochimie Endocrinienne et Oncologique, GH Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5406-8981","authenticated-orcid":false,"given":"Christophe","family":"Tr\u00e9sallet","sequence":"additional","affiliation":[{"name":"Service de Chirurgie G\u00e9n\u00e9rale, Visc\u00e9rale, Endocrinienne, GH Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Facult\u00e9 de M\u00e9decine, Sorbonnes Universit\u00e9s, GRC-14 BIOSFAST , Paris ,","place":["France"]},{"name":"Laboratoire D\u2019imagerie Fonctionnelle, unit\u00e9 INSERM U 678, Facult\u00e9 de M\u00e9decine Piti\u00e9-Salp\u00eatri\u00e8re , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Hausfater","sequence":"additional","affiliation":[{"name":"Service d\u2019Accueil des Urgences, GH Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique H\u00f4pitaux de Paris , Paris 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