{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:01:20Z","timestamp":1792213280487,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Arginine vasopressin (AVP) is a neuroendocrine hormone essential for fluid balance, vascular tone, and the endocrine stress response. However, its clinical measurement is limited by instability and technical challenges. Copeptin, the C-terminal segment of the AVP precursor, is secreted in equimolar amounts with AVP and serves as a stable, measurable surrogate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Content<\/jats:title>\n                    <jats:p>This mini-review outlines the synthesis, release, and physiological roles of AVP and copeptin, emphasizing their relevance in endocrine regulation. It highlights copeptin\u2019s diagnostic utility in differentiating AVP-deficiency (AVP-D), AVP-resistance (AVP-R), and primary polydipsia (PP): conditions that share overlapping clinical features. Traditional diagnostic methods such as the water deprivation test (WDT) are contrasted with copeptin-based approaches, which offer improved accuracy and patient tolerability. The review summarizes diagnostic thresholds for baseline and stimulated copeptin levels using stimulation, such as hypertonic saline or arginine, and discusses their integration into clinical algorithms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Copeptin has emerged as a reliable endocrine biomarker for AVP secretion and is increasingly used in the diagnostic evaluation of polyuria-polydipsia syndromes. Its stability, accessibility, and diagnostic performance support its adoption as a first-line tool in endocrine diagnostics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jalm\/jfaf153","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T11:54:37Z","timestamp":1757591677000},"page":"143-154","source":"Crossref","is-referenced-by-count":6,"title":["Copeptin as a Marker for Vasopressin Dysregulation and Diagnosis"],"prefix":"10.1093","volume":"11","author":[{"given":"Seema","family":"Khattri Bhandari","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine , Nashville, TN ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6051-3858","authenticated-orcid":false,"given":"Shu-Ling","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine , Nashville, TN ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"2026010511265717900_jfaf153-B1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/295299a0","article-title":"Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin\u2013neurophysin II precursor","volume":"295","author":"Land","year":"1982","journal-title":"Nature"},{"key":"2026010511265717900_jfaf153-B2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1399-3011.1986.tb01827.x","article-title":"Ontogeny of bovine neurohypophysial hormone precursors. 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