{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:49:48Z","timestamp":1781135388114,"version":"3.54.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007365","name":"Fondazione IRCCS Policlinico San Matteo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007365","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anti-Drug Policies Department"},{"name":"Presidency of the Council of Ministers"},{"name":"Instituti Clinici Scientifici Maugeri IRCCS Pavia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The rise of synthetic cathinones (SC), and in particular 3,4-MDPHP (3,4-methylenedioxy-\u03b1-pyrrolidinohexanophenone), is a concerning health threat. This paper represents the most extensive case series on 3,4-MDPHP suspected intoxications to date, offering a detailed analysis of its impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study presents the analytical findings for 108 hospitalized patients who tested positive for 3,4-MDPHP, out of a total of 465 subjects admitted for suspected new psychoactive substances (NPS) intoxication. Analyses were performed by GC-MS and LC-MS\/MS. The potential cross-reactivity of 3,4-MDPHP with the Syva EMIT II Plus urine ecstasy immunoassay is also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>3,4-MDPHP was detected in 56% of NPS positive cases. A wide range of 3,4-MDPHP concentrations was observed in both blood (1\u2013257\u2005ng\/mL) and urine (2\u201332 250\u2005ng\/mL). 3,4-MDPHP was the sole detected substance in 73.1% of cases, while 26.9% involved co-consumption with other drugs of abuse, primarily cocaine. Investigations about 3,4-MDPHP cross-reactivity with Syva EMIT II Plus urine ecstasy demonstrated that unmodified 3,4-MDPHP does not trigger a positive result, but its metabolites seem to be involved in a positive cross-reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirms the high prevalence (108\/465) of 3,4-MDPHP in NPS related intoxication cases in our cohort. It is essential for clinical laboratories and emergency departments to be aware of the potential cross-reactivity in ecstasy immunoassay, as this may lead to significant diagnostic errors and misinterpretation of results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jalm\/jfaf165","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T08:35:46Z","timestamp":1763022946000},"page":"61-72","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of 3,4-Methylenedioxy-\u03b1-Pyrrolidinohexanophenone (3,4-MDPHP) in 465 Suspected Intoxication Cases and Cross-Reactivity Evaluation in an Ecstasy Immunoassay"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-4571","authenticated-orcid":false,"given":"Maurizio","family":"Pasi","sequence":"first","affiliation":[{"name":"Laboratorio Ultraspecialistico di Patologia Clinica Farmacotossicologia e Sostanze d\u2019abuso, Laboratorio Analisi Chimico Cliniche, Dipartimento di Medicina Diagnostica e di Laboratorio, Fondazione IRCCS Policlinico San Matteo , Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Giardini","sequence":"additional","affiliation":[{"name":"Laboratorio Ultraspecialistico di Patologia Clinica Farmacotossicologia e Sostanze d\u2019abuso, Laboratorio Analisi Chimico Cliniche, Dipartimento di Medicina Diagnostica e di Laboratorio, Fondazione IRCCS Policlinico San Matteo , Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Buscaglia","sequence":"additional","affiliation":[{"name":"U.O. Tossicologia, Centro Antiveleni di Pavia, Centro Nazionale di Informazione Tossicologica, Laboratori di Tossicologia Clinica e Sperimentale, Istituti Clinici Scientifici Maugeri IRCCS , Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azzurra","family":"Schicchi","sequence":"additional","affiliation":[{"name":"U.O. Tossicologia, Centro Antiveleni di Pavia, Centro Nazionale di Informazione Tossicologica, Laboratori di Tossicologia Clinica e Sperimentale, Istituti Clinici Scientifici Maugeri IRCCS , Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo A","family":"Locatelli","sequence":"additional","affiliation":[{"name":"U.O. Tossicologia, Centro Antiveleni di Pavia, Centro Nazionale di Informazione Tossicologica, Laboratori di Tossicologia Clinica e Sperimentale, Istituti Clinici Scientifici Maugeri IRCCS , Pavia ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giampreti","sequence":"additional","affiliation":[{"name":"Centro Antiveleni di Bergamo, ASST Papa Giovanni XXIII , Bergamo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariapina","family":"Gallo","sequence":"additional","affiliation":[{"name":"Centro Antiveleni di Bergamo, ASST Papa Giovanni XXIII , Bergamo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Albertini","sequence":"additional","affiliation":[{"name":"Laboratorio Ultraspecialistico di Patologia Clinica Farmacotossicologia e Sostanze d\u2019abuso, Laboratorio Analisi Chimico Cliniche, Dipartimento di Medicina Diagnostica e di Laboratorio, 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