{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:03:42Z","timestamp":1784725422703,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study assessed the ability of the complete blood count, differential, and reticulocyte (CDR) mode of the Mindray BC-6800 Plus analyzer to correct platelet aggregation by disaggregating platelets, evaluating how aggregation severity impacts accuracy to define an objective threshold for resampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Agreement was assessed between CDR mode and the electrical impedance method for platelet counts in normal specimens using Pearson correlation, Passing\u2013Bablok regression, and Bland\u2013Altman analysis. The CDR mode\u2019s ability to correct false elevations caused by microcytes\/fragments and false reductions caused by large platelets was evaluated by comparing CDR channel platelet count results (PLT-OF) with smear-estimated values (PLT-M) and fluorescence-method results (PLT-F). Disaggregation efficacy in aggregated samples was analyzed using the MC-80 digital morphology system. The optimal disaggregation threshold was determined by ROC analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In normal specimens, PLT-OF showed a significant correlation with the electrical impedance-method platelet count results (PLT-I) (r = 0.999, P &amp;lt; 0.001). Passing\u2013Bablok regression (PLT-I = 1.00 \u00d7 PLT-OF) and Bland\u2013Altman analysis demonstrated excellent agreement. For samples with PLT-I false abnormalities, the CDR mode effectively corrected both false elevations (due to microcytes\/fragments) and false reductions (due to large platelets), showing no significant differences between PLT-OF and PLT-M or PLT-F (P &amp;gt; 0.05). In platelet-aggregated specimens, PLT-OF was significantly higher than PLT-I (P &amp;lt; 0.001). ROC analysis established 162 aggregates as the optimal threshold for effective disaggregation [area under the curve (AUC) = 0.776]. The dissociation rate was significantly greater in the mild vs severe-aggregation group (P = 0.004). Combining aggregate count with a PLT-OF to PLT-I difference (&amp;gt;115 \u00d7 109\/L) improved prediction accuracy (AUC = 0.841).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The CDR channel of the Mindray BC-6800 Plus analyzer effectively corrects spurious platelet counts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jalm\/jfag092","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T11:40:37Z","timestamp":1780141237000},"source":"Crossref","is-referenced-by-count":0,"title":["Overcoming Platelet Aggregation Interference: Evaluation of the Complete Blood Count, Differential, and Reticulocyte (CDR) Mode on an Automated Analyzer for Accurate Platelet Counting"],"prefix":"10.1093","author":[{"given":"Jia-le","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-jun","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouzhou","family":"FengHuang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"2026072208015011300_jfag092-B1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/01.mbc.0000469521.23628.2d","article-title":"Platelet disorders: an overview","volume":"26","author":"Krishnegowda","year":"2015","journal-title":"Blood Coagul Fibrinolysis"},{"key":"2026072208015011300_jfag092-B2","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/jth.14202","article-title":"Learning by counting blood platelets in population studies: survey and perspective a long way after Bizzozero","volume":"16","author":"Izzi","year":"2018","journal-title":"J Thromb Haemost"},{"key":"2026072208015011300_jfag092-B3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.blre.2011.01.006","article-title":"Current practice and future directions for optimization of platelet transfusions in patients with severe therapy-induced cytopenia","volume":"25","author":"Apelseth","year":"2011","journal-title":"Blood Rev"},{"key":"2026072208015011300_jfag092-B4","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3390\/jcm9030808","article-title":"Platelet counting: ugly traps and good advice. 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