{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:05:36Z","timestamp":1789657536677,"version":"4.0.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Candy\u2019s Foundation"},{"name":"Research Council of Herlev and Gentofte Hospital","id":[{"id":"https:\/\/ror.org\/051dzw862","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Mauritzen la Fountaine Foundation"},{"name":"the Finnish Foundation for Cardiovascular Research","id":[{"id":"https:\/\/ror.org\/020apt798","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Turku University Foundation","id":[{"id":"https:\/\/ror.org\/02kjggt26","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Varsinais-Suomi Regional Fund"},{"DOI":"10.13039\/501100003125","name":"Finnish Cultural Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long forms of cardiac troponin T (cTnT) are promising markers that may differentiate myocardial infarction from other causes of acute and chronic myocardial injury. However, to understand the clinical utility of long cTnT, knowledge of the half-life (T\u00bd) is key. By using auto-transfusion in humans we determined the T\u00bd of long forms of cTnT and compared long cTnT to a commercial high-sensitivity total cTnT assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with ST-segment-elevation-myocardial infarction were included within 24\u2005h after revascularization and underwent plasmapheresis to obtain plasma with a high cTnT concentration. After at least 3 weeks, patients returned for an autologous plasma re-transfusion followed by repeated blood sampling. A novel assay measured long cTnT and a commercially available assay measured total cTnT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 17 patients with median age 63 years (25th\u201375th percentiles 59\u201370), and 4 (24%) were female. The median concentrations after transfusion were 99\u2005ng\/L (54\u2013125) for long cTnT vs 252\u2005ng\/L (233\u2013322) for total cTnT. The median ratio of long cTnT to total cTnT was 0.39 (0.26\u20130.55) after transfusion and declined to 0.30 (0.20\u20130.44) after 60\u2005min. Long cTnT displayed a 2-phase exponential decay, similar to what was observed for total cTnT but with shorter T\u00bd both for the distribution phase [16\u2005min (11\u201318) vs 22\u2005min (20\u201324), P &amp;lt; 0.001] and the elimination phase [103\u2005min (78\u2013125) vs 133\u2005min (114\u2013168), P &amp;lt; 0.001].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The elimination of long forms of cTnT was faster than for total cTnT following re-transfusion. This understanding could aid in differentiating myocardial infarction from other causes of acute and chronic myocardial injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jalm\/jfag142","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:22:23Z","timestamp":1787570543000},"source":"Crossref","is-referenced-by-count":0,"title":["The Half-Life of Long Forms of Cardiac Troponin T"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4274-6268","authenticated-orcid":false,"given":"Rasmus Bo","family":"Hasselbalch","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Herlev-Gentofte Hospital , Copenhagen ,","place":["Denmark"]},{"name":"Department of Emergency Medicine, Copenhagen University Hospital\u2014Herlev-Gentofte Hospital , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen 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