{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:02:40Z","timestamp":1790082160905,"version":"4.0.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To provide independent evidence of the analytical performance of the i-STAT high-sensitivity troponin I assay using the i-STAT Alinity system, we assessed imprecision, hemolysis interference, and concordance with laboratory assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine whole-blood samples with concentrations from below the limit of quantitation to approximately 10 times the upper reference limit were analyzed 20 times in succession. Four samples across a similar range were used to assess hemolysis interference induced by repeated aspiration through a 25-gauge needle. Concordance with 4 laboratory comparison assays was assessed with 200 samples by Pearson correlation and \u03ba statistics at the upper reference limit (URL) and compared to concordance between the laboratory assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CVs were &amp;lt;10% across the range of 10 to 20\u2005ng\/L, below the universal URL. There were small changes with hemolysis but within acceptable limits (\u00b13\u2005ng\/L below 10\u2005ng\/L and \u00b130% above 10\u2005ng\/L). Correlation coefficients with high-sensitivity troponin I laboratory assays ranged from 0.96 to 0.99, and performance across the URL ranged from a \u03ba of 0.67 to 0.89, similar to results between laboratory assays (correlation range, 0.87\u20130.98; \u03ba at the URL range, 0.71\u20130.88).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Imprecision met manufacturer claims and was consistent with a high-sensitivity assay. There was no significant hemolysis interference. Concordance with comparison laboratory assays was similar to that between laboratory assays. The results support performance characteristics previously reported by the manufacturer, and the assay and analyzer offer acceptable performance for intended clinical use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Australian New Zealand Clinical Trials Registry number<\/jats:title>\n                    <jats:p>ACTRN12625000710426.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jalm\/jfag143","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:34:47Z","timestamp":1787657687000},"source":"Crossref","is-referenced-by-count":0,"title":["Analytical Verification of a Point-of-Care High-Sensitivity Troponin I Assay"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-0344","authenticated-orcid":false,"given":"John W","family":"Pickering","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Otago Christchurch , Christchurch ,","place":["New Zealand"]},{"name":"Department of Emergency Medicine, Christchurch Hospital , Christchurch ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Buchan","sequence":"additional","affiliation":[{"name":"Canterbury Health Laboratories, Christchurch Hospital , Christchurch ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Rodney","sequence":"additional","affiliation":[{"name":"Canterbury Health Laboratories, Christchurch Hospital , Christchurch ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamsin","family":"Attenburrow","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Christchurch Hospital , Christchurch ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-3814","authenticated-orcid":false,"given":"Laura R","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Christchurch Hospital , Christchurch ,","place":["New Zealand"]},{"name":"Department of Surgery and Critical Care, University of Otago Christchurch , Christchurch ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9399-5227","authenticated-orcid":false,"given":"Martin","family":"Than","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Christchurch Hospital , Christchurch ,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-818X","authenticated-orcid":false,"given":"Christopher M","family":"Florkowski","sequence":"additional","affiliation":[{"name":"Canterbury Health Laboratories, Christchurch Hospital , Christchurch ,","place":["New 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