{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:56:15Z","timestamp":1790560575135,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23MH130728"],"award-info":[{"award-number":["K23MH130728"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG072973"],"award-info":[{"award-number":["P30 AG072973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adolescence is a critical period of neurodevelopment with the emergence of chronic medical conditions and increasing exposure to long-term medications. Phosphorylated tau at threonine 217 (p-tau217) is a sensitive blood-based biomarker of neuropathology in older adults, yet its developmental behavior and susceptibility to common clinical factors in youth are unclear. Here we tested whether p-tau217 varies with age, comorbidity, or medication use during adolescence and whether collection method (venous vs Tasso+ capillary) yields comparable concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In an adolescent cohort, plasma p-tau217 was measured by Simoa HD-X. Paired venous and Tasso+ capillary samples were also analyzed from adult volunteers for methodological comparison.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In adolescents (n = 41; mean age 16 \u00b1 2.6 years), p-tau217 did not correlate with age or body mass index z score and did not differ by psychiatric, cardiometabolic, or gastrointestinal comorbidity nor by corresponding medication use. In contrast, p-tau217 concentrations were &amp;gt;10-fold higher in Tasso+ capillary plasma than venous plasma, a discordance replicated in paired adult samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was no clear evidence of associations between plasma p-tau217 and common clinical variables in adolescence, yet plasma p-tau217 is highly sensitive to biospecimen collection method. Venous and Tasso+ capillary plasma should not be directly compared or pooled until methodological differences are resolved. These data provide the first look at the relationship between p-tau217 and clinical factors during adolescence and provide a critical methodological caution for pediatric neuroscience and decentralized biomarker studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jalm\/jfag147","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:33:38Z","timestamp":1788521618000},"source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Age, Comorbidity, and Current Medication Use on Plasma p-tau217 in Adolescents: A Pilot Study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-3132","authenticated-orcid":false,"given":"Stephani L","family":"Stancil","sequence":"first","affiliation":[{"name":"Divisions of Adolescent Medicine and Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children\u2019s Mercy Kansas City , MO ,","place":["United States"]},{"name":"Department of Pediatrics, University of Missouri-Kansas City School of Medicine , Kansas City, MO ,","place":["United States"]},{"name":"Department of Pediatrics, University of Kansas Medical Center School of Medicine , Kansas City, KS ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah E","family":"Brewe","sequence":"additional","affiliation":[{"name":"Divisions of Adolescent Medicine and Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children\u2019s Mercy Kansas City , MO ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Mayfield","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease Research Center, University of Kansas , Kansas City, KS ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-4190","authenticated-orcid":false,"given":"Jill","family":"Morris","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease Research Center, University of Kansas , Kansas City, KS ,","place":["United States"]},{"name":"Department of Neurology, University of Kansas Medical Center , Kansas City, KS ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2026092721255503900_jfag147-B1","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.3390\/ijms26146633","article-title":"P-tau217 as a biomarker in Alzheimer's disease: applications in Latin American populations","volume":"26","author":"Varela-Vidales","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026092721255503900_jfag147-B2","first-page":"1797","article-title":"Plasma p-tau231 and 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adults without cognitive impairment: a meta-analysis","volume":"83","author":"Malek-Ahmadi","year":"2026","journal-title":"JAMA Neurol"},{"key":"2026092721255503900_jfag147-B6","doi-asserted-by":"crossref","first-page":"9207","DOI":"10.3390\/ijms22179207","article-title":"Tau protein interaction partners and their roles in Alzheimer's disease and other tauopathies","volume":"22","author":"Sinsky","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026092721255503900_jfag147-B7","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/alz.12787","article-title":"Confounding factors of Alzheimer's disease plasma biomarkers and their impact on clinical performance","volume":"19","author":"Pichet Binette","year":"2023","journal-title":"Alzheimers Dement"},{"key":"2026092721255503900_jfag147-B8","article-title":"Plasma Alzheimer's disease biomarker variability: amyloid-independent and amyloid-dependent 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