{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T20:02:43Z","timestamp":1771704163000,"version":"3.50.1"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministry of Planning, Development & Special Initiatives"},{"name":"International Research Support Initiative Program"},{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>At conception, the infant gut barrier is immature, gradually developing with regular intake of maternal milk. This study addressed whether the barrier-strengthening effect of breast feeding might be attributable, at least in part, to autochthonous beneficial human milk bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Twelve bacterial strains from the breast milk of Pakistani mothers who underwent cesarean delivery (NPL-88, NPL-157, NPL-179, NPL-181, NPL-388 (Limosilactobacillus reuteri), NPL-76, NPL-495, NPL-504 (Limosilactobacillus fermentum), NPL-415 (Lactobacillus pentosus), NPL-412, NPL-416 (Lactiplantibacilllus plantarum) and NPL-374 (Bifidobacterium longum) were shortlisted based on their tolerance to acidic pH (2.8\u20134.2) and bile (0.1\u20130.3%). The effect of these bacteria on gut barrier function in the presence and absence of pathogens was assessed as changes in transepithelial electrical resistance (TEER) in the human T84 colonic epithelial cell line and in murine enteroid-derived monolayers (EDMs). The TEER of T84 cells monolayers rose in the presence of most of the human milk strains, being most pronounced in case of L. reuteri NPL-88 (34% within five h), exceeding the effect of the well-known probiotic L. acidophilus (20%). qRT-PCR, western blot and immunofluorescent staining associated the increase in TEER with enhanced expression of tight junction proteins. Pretreatment of murine EDMs with NPL-88 also largely prevented the ability of the pathogen, Salmonella, to decrease TEER (87\u00a0\u00b1\u00a01.50%; P\u00a0&amp;lt;\u00a00.0001, n\u00a0=\u00a04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Human milk lactic acid bacteria are potential probiotics that can strengthen gut barrier function and protect breastfed neonates against enteric infections.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jambio\/lxac029","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T19:56:17Z","timestamp":1678996577000},"source":"Crossref","is-referenced-by-count":12,"title":["Potentially probiotic<i>Limosilactobacillus reuteri<\/i>from human milk strengthens the gut barrier in T84 cells and a murine enteroid model"],"prefix":"10.1093","volume":"134","author":[{"given":"Jasia","family":"Anjum","sequence":"first","affiliation":[{"name":"National Probiotic Laboratory, National Institute for Biotechnology and Genetic Engineering College (NIBGE-C) , Faisalabad 38000, (Punjab) Pakistan"},{"name":"Pakistan Institute of Engineering and Applied Sciences (PIEAS) , Nilore, Islamabad 45650, (ICT) Pakistan"},{"name":"Division of Gastroenterology, Department of Medicine, University of California San Diego School of Medicine , 9500 Gilman Drive, La Jolla, CA 92093-0063 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Quach","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of California San Diego School of Medicine , 9500 Gilman Drive, La Jolla, CA 92093-0063 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preedajit","family":"Wongkrasant","sequence":"additional","affiliation":[{"name":"Current affiliation: Department of Physiology and Membrane Biology, University of California Davis School of Medicine , 4610 X Street, Sacramento, CA 95817 , USA"},{"name":"Department of Physiology, Faculty of Science, Mahidol University , Rama VI Road, Rajathevi, Bangkok, 10400 , Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahid","family":"Nazir","sequence":"additional","affiliation":[{"name":"Dept of Pediatrics, Shifa International Hospitals Ltd , Islamabad 44000 , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Tariq","sequence":"additional","affiliation":[{"name":"National Probiotic Laboratory, National Institute for Biotechnology and Genetic Engineering College (NIBGE-C) , Faisalabad 38000, (Punjab) Pakistan"},{"name":"Pakistan Institute of Engineering and Applied Sciences (PIEAS) , Nilore, Islamabad 45650, (ICT) Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim E","family":"Barrett","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, University of California San Diego School of Medicine , 9500 Gilman Drive, La Jolla, CA 92093-0063 , USA"},{"name":"Current affiliation: Department of Physiology and Membrane Biology, University of California Davis School of Medicine , 4610 X Street, Sacramento, CA 95817 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-1419","authenticated-orcid":false,"given":"Arsalan","family":"Zaidi","sequence":"additional","affiliation":[{"name":"National Probiotic Laboratory, National Institute for Biotechnology and Genetic Engineering College (NIBGE-C) , Faisalabad 38000, (Punjab) Pakistan"},{"name":"Pakistan Institute of Engineering and Applied Sciences (PIEAS) , Nilore, Islamabad 45650, (ICT) Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"2023031616485610800_","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/MPG.0b013e31818f091b","article-title":"Probiotic Lactobacilli in breast milk and infant 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