{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:01:51Z","timestamp":1780354911051,"version":"3.54.1"},"reference-count":117,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009526","name":"Amrita Vishwa Vidyapeetham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009526","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontitis is an inflammatory disease caused by microbial infections of the gum. At an advanced stage, periodontitis can even destroy the alveolar bone. Fusobacterium nucleatum, Prevotella intermedia, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Capnocytophaga gingivalis, and Pr. nigrescens are the major pathogens in periodontitis. Scaling and root planning are used together with local or systemic antibiotics to treat periodontitis. The difficulty in complete eradication of periodontal pathogens frequently leads to the relapse of the disease. As not many new antibiotics are available in the market, many researchers are now focusing on developing alternative strategies against periodontal microbes. This review provides an overview of the possible use of bacteriophages, lysins, honey, plant extracts, metallic salts, nanoparticles, and vaccines as alternative therapeutic agents against periodontal infections. The information provided here could help in designing alternative therapeutics for the treatment of periodontal infections.<\/jats:p>","DOI":"10.1093\/jambio\/lxac039","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T18:42:24Z","timestamp":1678992144000},"source":"Crossref","is-referenced-by-count":15,"title":["An update on possible alternative therapeutics for future periodontal disease management"],"prefix":"10.1093","volume":"134","author":[{"given":"Vishnu","family":"Das","sequence":"first","affiliation":[{"name":"Amrita School of Nanosciences and Molecular medicine, Amrita Vishwa Vidyapeetham, AIMS , Ponekkara, Cochin 682041 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Vinod","sequence":"additional","affiliation":[{"name":"Amrita School of Nanosciences and Molecular medicine, Amrita Vishwa Vidyapeetham, AIMS , Ponekkara, Cochin 682041 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha","family":"Biswas","sequence":"additional","affiliation":[{"name":"Amrita School of Nanosciences and Molecular medicine, Amrita Vishwa Vidyapeetham, AIMS , Ponekkara, Cochin 682041 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, AIMS , Ponekkara, Cochin 682041 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Biswas","sequence":"additional","affiliation":[{"name":"Amrita School of Nanosciences and Molecular medicine, Amrita Vishwa Vidyapeetham, AIMS , Ponekkara, Cochin 682041 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"2023031615362081800_","doi-asserted-by":"crossref","first-page":"8367846","DOI":"10.1155\/2018\/8367846","article-title":"Honey as a potential natural antioxidant medicine: an insight into its molecular mechanisms of action","volume":"2018","author":"Ahmed","year":"2018","journal-title":"Oxid Med Cell Long"},{"key":"2023031615362081800_","doi-asserted-by":"crossref","first-page":"2464507","DOI":"10.1155\/2019\/2464507","article-title":"Antibacterial potency of honey","volume":"2019","author":"Albaridi","year":"2019","journal-title":"Int J Microbiol"},{"key":"2023031615362081800_","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2147\/NSA.S325594","article-title":"Bacterial biofilm destruction: a focused review on the recent use of phage-based strategies with other antibiofilm 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