{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:56:48Z","timestamp":1790812608592,"version":"4.1.0"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["UID\/CVT\/00153\/2019"],"award-info":[{"award-number":["UID\/CVT\/00153\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008382","name":"Regional Fund for Science and Technology","doi-asserted-by":"publisher","award":["M3.1.a\/F\/017\/2018"],"award-info":[{"award-number":["M3.1.a\/F\/017\/2018"]}],"id":[{"id":"10.13039\/100008382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Isolation and characterization of lactobacilli from human milk and determination of their probiotic, technological, and in vitro health-promoting properties with a view to their potential use in food fermentation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>Seven lactobacilli isolates were obtained from human milk and identified as Lacticaseibacillus paracasei (isolates BM1\u2013BM6) and Lactobacillus gasseri (BM7). The isolates were examined in vitro for their technological, probiotic, and health-promoting potential. Overall, all isolates showed important technological properties based on the ability to grow in milk whey, a high to moderate acidification capacity and the absence of undesirable enzymatic activities. Lacticaseibacillus gasseri (BM7) differed from the L. paracasei isolates by the absence of several glycosidases and the inability to ferment lactose. Isolates L. paracasei BM3 and BM5 produced exopolysaccharides (EPS) from lactose. All isolates showed probiotic potential as they were tolerant to simulated gastrointestinal conditions, had high cell surface hydrophobicity, had not acquired resistance to relevant antibiotics and had no virulence characteristics. All L. paracasei showed high antimicrobial activity against various pathogenic bacteria and fungi, while L. gasseri showed a narrower spectrum of antimicrobial activity. All isolates showed health-promoting potential in vitro, as evidenced by high cholesterol-lowering activity, high ACE inhibitory activity and marked antioxidant activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>All strains showed excellent probiotic and technological properties for use in lactic ferments.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxad122","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T10:30:30Z","timestamp":1686393030000},"source":"Crossref","is-referenced-by-count":8,"title":["Probiotic, technological, and health-related characteristics of lactobacilli isolated from breast milk"],"prefix":"10.1093","volume":"134","author":[{"given":"Vanessa","family":"Pires","sequence":"first","affiliation":[{"name":"Faculty of Agricultural Sciences and Environment, University of the Azores , 9700-042 Angra do Hero\u00edsmo, Azores , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana C","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Institute of Agricultural and Environmental Research and Technology (IITAA), University of the Azores , 9700-042 Angra do Hero\u00edsmo, Azores , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9892-9031","authenticated-orcid":false,"given":"Sofia P M","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculty of Agricultural Sciences and Environment, University of the Azores , 9700-042 Angra do Hero\u00edsmo, Azores , Portugal"},{"name":"Institute of Agricultural and Environmental Research and Technology (IITAA), University of the Azores , 9700-042 Angra do Hero\u00edsmo, Azores , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Juraskova","sequence":"additional","affiliation":[{"name":"Faculty of Agricultural Sciences and Environment, University of the Azores , 9700-042 Angra do Hero\u00edsmo, Azores , Portugal"},{"name":"Institute of Agricultural and Environmental Research and Technology (IITAA), University of the Azores , 9700-042 Angra do Hero\u00edsmo, Azores , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-0071","authenticated-orcid":false,"given":"Celia C G","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculty of Agricultural Sciences and Environment, University of the Azores , 9700-042 Angra do Hero\u00edsmo, Azores , Portugal"},{"name":"Institute of Agricultural and Environmental Research and Technology (IITAA), University of the Azores , 9700-042 Angra do Hero\u00edsmo, Azores , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"2023062713061545200_bib1","doi-asserted-by":"crossref","first-page":"108387","DOI":"10.1016\/j.lwt.2019.108387","article-title":"Functional and technological properties of exopolysaccharide producing autochthonous Lactobacillus plantarum strain AAS3 from dry fish based fermented food","volume":"114","author":"Aarti","year":"2019","journal-title":"LWT"},{"key":"2023062713061545200_bib2","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.3168\/jds.S0022-0302(03)73781-3","article-title":"Production of free conjugated linoleic acid by Lactobacillus acidophilus and Lactobacillus casei of human intestinal origin","volume":"86","author":"Alonso","year":"2003","journal-title":"J Dairy Sci"},{"key":"2023062713061545200_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.humic.2016.09.001","article-title":"Diet influence on the gut microbiota and dysbiosis related to nutritional disorders","volume":"1","author":"Alou","year":"2016","journal-title":"Hum Microbiome J"},{"key":"2023062713061545200_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1017\/S0022029909990173","article-title":"Effect of fermented milk containing Lactobacillus acidophilus and bifidobacterium longum on plasma lipids of women with normal or moderately elevated cholesterol","volume":"76","author":"Andrade","year":"2009","journal-title":"J Dairy Res"},{"key":"2023062713061545200_bib5","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.3168\/jds.2014-8860","article-title":"Lactobacillus gasseri requires peptides, not proteins or free amino acids, for growth in milk","volume":"98","author":"Arakawa","year":"2015","journal-title":"J Dairy Sci"},{"key":"2023062713061545200_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000203284","article-title":"Cholesterol-lowering effect of probiotic yogurt in comparison with ordinary yogurt in mildly to moderately hypercholesterolemic subjects","volume":"54","author":"Ataie-Jafari","year":"2009","journal-title":"Ann Nutr Metab"},{"key":"2023062713061545200_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0168-1605(94)90157-0","article-title":"a dynamic approach to predicting bacterial growth in food","volume":"23","author":"Baranyi","year":"1994","journal-title":"Int J Food Microbiol"},{"key":"2023062713061545200_bib8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/ajcp\/45.4_ts.493","article-title":"Antibiotic susceptibility testing by a standardized single disc method","volume":"45","author":"Bauer","year":"1966","journal-title":"Am J Clin Pathol"},{"key":"2023062713061545200_bib9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12223-012-0121-x","article-title":"Functional properties of Lactobacillus strains isolated from dairy products","volume":"57","author":"Buj\u0148\u00e1kov\u00e1","year":"2012","journal-title":"Folia Microbiol"},{"key":"2023062713061545200_bib10","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3390\/nu12051468","article-title":"Recipe for a healthy gut: intake of unpasteurised milk is associated with increased lactobacillus abundance in the human gut microbiome","volume":"12","author":"Butler","year":"2020","journal-title":"Nutrients"},{"key":"2023062713061545200_bib11","doi-asserted-by":"crossref","first-page":"e01738","DOI":"10.1128\/AEM.01738-18","article-title":"Genus-wide assessment of antibiotic resistance in Lactobacillus spp","volume":"85","author":"Campedelli","year":"2019","journal-title":"Appl Environ Microbiol"},{"key":"2023062713061545200_bib12","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.3389\/fmicb.2018.02426","article-title":"Interactions of surface exopolysaccharides from bifidobacterium and Lactobacillus within the intestinal environment","volume":"9","author":"Castro-Bravo","year":"2018","journal-title":"Front Microbiol"},{"key":"2023062713061545200_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.fm.2014.03.005","article-title":"Impact of microbial cultures on proteolysis and release of bioactive peptides in fermented milk","volume":"42","author":"Chaves-L\u00f3pez","year":"2014","journal-title":"Food Microbiol"},{"key":"2023062713061545200_bib14","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/MMBR.65.2.232-260.2001","article-title":"Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance","volume":"65","author":"Chopra","year":"2001","journal-title":"Microbiol Mol Biol Rev"},{"key":"2023062713061545200_bib15","first-page":"251","article-title":"Performance Standards for antimicrobial susceptibility testing","volume-title":"CLSI Supplement M100S","author":"CLSI","year":"2016"},{"key":"2023062713061545200_bib16","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.3390\/foods11152276","article-title":"Lactic acid bacteria in raw-milk cheeses: from starter cultures to probiotic functions","volume":"11","author":"Coelho","year":"2022","journal-title":"Foods"},{"key":"2023062713061545200_bib17","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(71)90292-9","article-title":"Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung","volume":"20","author":"Cushman","year":"1971","journal-title":"Biochem Pharmacol"},{"key":"2023062713061545200_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12602-017-9270-1","article-title":"Evaluation of potential probiotics isolated from human milk and colostrum","volume":"9","author":"Damaceno","year":"2017","journal-title":"Probiotics & Antimicro Prot"},{"key":"2023062713061545200_bib19","doi-asserted-by":"crossref","first-page":"S248","DOI":"10.1016\/S1590-8658(07)60004-8","article-title":"Probiotics: from research to consumer","volume":"38","author":"Del\u00a0Piano","year":"2006","journal-title":"Dig Liver Dis"},{"key":"2023062713061545200_bib20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.fm.2016.11.014","article-title":"Genetic diversity, safety and technological characterization of lactic acid bacteria isolated from artisanal Pico cheese","volume":"63","author":"Domingos-Lopes","year":"2017","journal-title":"Food Microbiol"},{"key":"2023062713061545200_bib21","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1111\/jam.14733","article-title":"Histamine and cholesterol lowering abilities of lactic acid bacteria isolated from artisanal Pico cheese","volume":"129","author":"Domingos-Lopes","year":"2020","journal-title":"J Appl Microbiol"},{"key":"2023062713061545200_bib22","first-page":"1","volume-title":"Evaluation of Health and Nutritional Properties of Powder Milk and Live Lactic Acid Bacteria","author":"FAO\/WHO","year":"2001"},{"key":"2023062713061545200_bib23","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1079\/BJN2002628","article-title":"Probiotics as modulators of the gut flora","volume":"88","author":"Fooks","year":"2002","journal-title":"Br J Nutr"},{"key":"2023062713061545200_bib24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3390\/pathogens3030769","article-title":"Early development of the gut microbiota and immune health","volume":"3","author":"Francino","year":"2014","journal-title":"Pathogens"},{"key":"2023062713061545200_bib25","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1099\/mic.0.052928-0","article-title":"Identification of lactose phosphotransferase systems in Lactobacillus gasseri ATCC 33323 required for lactose utilization","volume":"158","author":"Francl","year":"2012","journal-title":"Microbiology"},{"key":"2023062713061545200_bib26","doi-asserted-by":"crossref","first-page":"11866","DOI":"10.3390\/ijms222111866","article-title":"Short-and long-term implications of Human milk microbiota on maternal and child health","volume":"22","author":"Garc\u00eda-Ricobaraza","year":"2021","journal-title":"IJMS"},{"key":"2023062713061545200_bib27","first-page":"87","article-title":"Experimental conditions may affect reproducibility of the \u03b2-galactosidase assay","volume":"100","author":"Giacomini","year":"1992","journal-title":"FEMS Microbiol Lett"},{"key":"2023062713061545200_bib28","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1079\/BJN2002632","article-title":"Diet and cancer: assessing the risk","volume":"88","author":"Gill","year":"2002","journal-title":"Br J Nutr"},{"key":"2023062713061545200_bib29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.idairyj.2011.04.001","article-title":"Production of angiotensin-I-converting enzyme (ACE) inhibitory activity in milk fermented with probiotic strains: effects of calcium, pH and peptides on the ACE-inhibitory activity","volume":"21","author":"Gonzalez-Gonzalez","year":"2011","journal-title":"Int Dairy J"},{"key":"2023062713061545200_bib30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijfoodmicro.2017.10.025","article-title":"Anti-aflatoxigenic effect of organic acids produced by Lactobacillus plantarum","volume":"264","author":"Guimar\u00e3es","year":"2018","journal-title":"Int J Food Microbiol"},{"key":"2023062713061545200_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.lwt.2019.04.043","article-title":"Lactobacillus gasseri from human milk with probiotic potential and some technological properties","volume":"109","author":"Gunyakti","year":"2019","journal-title":"LWT"},{"key":"2023062713061545200_bib32","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document: the International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2023062713061545200_bib33","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/jam.12916","article-title":"Safety and technological properties of bacteriocinogenic enterococci isolates from Tunisia","volume":"119","author":"Jaouani","year":"2015","journal-title":"J Appl Microbiol"},{"key":"2023062713061545200_bib34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1517\/14712598.2013.758706","article-title":"Cholesterol lowering with bile salt hydrolase-active probiotic bacteria, mechanism of action, clinical evidence, and future direction for heart health applications","volume":"13","author":"Jones","year":"2013","journal-title":"Expert Opin Biol Ther"},{"key":"2023062713061545200_bib35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3390\/foods11020156","article-title":"Exopolysaccharides produced by lactic acid bacteria: from biosynthesis to health-promoting properties","volume":"11","author":"Jur\u00e1\u0161kov\u00e1","year":"2022","journal-title":"Foods"},{"key":"2023062713061545200_bib36","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.3168\/jds.2020-18704","article-title":"Isolation and characterization of lactic acid bacteria from human milk","volume":"103","author":"Kang","year":"2020","journal-title":"J Dairy Sci"},{"key":"2023062713061545200_bib37","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1016\/j.orcp.2013.10.001","article-title":"Health benefits of conjugated linoleic acid (CLA)","volume":"8","author":"Koba","year":"2014","journal-title":"Obes Res Clin Pract"},{"key":"2023062713061545200_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/foods5010013","article-title":"Biohydrogenation of linoleic acid by lactic acid bacteria for the production of functional cultured dairy products: a review","volume":"5","author":"Kuhl","year":"2016","journal-title":"Foods"},{"key":"2023062713061545200_bib39","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/08905436.2022.2092494","article-title":"Screening for probiotic attributes of lactic acid bacteria isolated from human milk and evaluation of their anti-diabetic potentials","volume":"36","author":"Kumar","year":"2022","journal-title":"Food Biotechnol"},{"key":"2023062713061545200_bib40","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1134\/S0003683812060075","article-title":"Scanning assay of \u03b2-galactosidase activity","volume":"48","author":"Li","year":"2012","journal-title":"Appl Biochem Microbiol"},{"key":"2023062713061545200_bib41","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3389\/fmicb.2017.00846","article-title":"Lactic acid bacteria and bifidobacteria with potential to design natural biofunctional health-promoting dairy foods","volume":"8","author":"Linares","year":"2017","journal-title":"Front Microbiol"},{"key":"2023062713061545200_bib42","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.3168\/jds.2019-17602","article-title":"Characterization of potentially probiotic lactic acid bacteria and bifidobacteria isolated from human colostrum","volume":"103","author":"Liu","year":"2020","journal-title":"J Dairy Sci"},{"key":"2023062713061545200_bib43","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ijfoodmicro.2009.05.020","article-title":"Detection of vanA and vanB2-containing enterococci from food samples in Spain, including Enterococcus faecium strains of CC17 and the new singleton ST425","volume":"133","author":"L\u00f3pez","year":"2009","journal-title":"Int J Food Microbiol"},{"key":"2023062713061545200_bib44","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.lwt.2015.10.045","article-title":"Characterization of lactic acid bacteria isolated from wheat bran sourdough","volume":"66","author":"Manini","year":"2016","journal-title":"LWT - Food Science and Technology"},{"key":"2023062713061545200_bib45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/08905436.2018.1519443","article-title":"Antifungal activity of lactic acid bacteria isolated from peanuts, gari, and orange fruit juice against food aflatoxigenic molds","volume":"32","author":"Marie","year":"2018","journal-title":"Food Biotechnol"},{"key":"2023062713061545200_bib46","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11551","article-title":"Reciprocal interactions of the intestinal microbiota and immune system","volume":"489","author":"Maynard","year":"2012","journal-title":"Nature"},{"key":"2023062713061545200_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/5584_2016_3","article-title":"Biodiversity of intestinal lactic acid bacteria in the healthy population","volume-title":"Advances in Microbiology, Infectious Diseases and Public Health","author":"Mikelsaar","year":"2016"},{"key":"2023062713061545200_bib48","doi-asserted-by":"crossref","first-page":"e0126387","DOI":"10.1371\/journal.pone.0126387","article-title":"AggLb is the largest cell-aggregation factor from Lactobacillus paracasei subsp. Paracasei BGNJ1\u201364, functions in collagen adhesion, and pathogen exclusion in vitro","volume":"10","author":"Miljkovic","year":"2015","journal-title":"PLoS One"},{"key":"2023062713061545200_bib49","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.4315\/0362-028X.JFP-10-392","article-title":"Characterization of certain bacterial strains for potential use as starter or probiotic cultures in dairy products","volume":"74","author":"Monteagudo-Mera","year":"2011","journal-title":"J Food Prot"},{"key":"2023062713061545200_bib50","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jgar.2022.05.014","article-title":"Characterization of resistome in Lactobacillus genomic sequences from the human gut","volume":"30","author":"Moradi","year":"2022","journal-title":"J Glob Antimicrob Resist"},{"key":"2023062713061545200_bib51","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3390\/nu13041123","article-title":"Human milk microbiota and oligosaccharides: a, glimpse into benefits, diversity, and correlations","volume":"13","author":"Moubareck","year":"2021","journal-title":"Nutrients"},{"key":"2023062713061545200_bib52","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.3168\/jds.2018-14989","article-title":"Assessing and comparing antioxidant activities of lactobacilli strains by using different chemical and cellular antioxidant methods","volume":"101","author":"Mu","year":"2018","journal-title":"J Dairy Sci"},{"key":"2023062713061545200_bib53","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.molmed.2014.12.002","article-title":"the infant microbiome development: mom matters","volume":"21","author":"Mueller","year":"2015","journal-title":"Trends Mol Med"},{"key":"2023062713061545200_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/10408699991279187","article-title":"Probiotic spectra of lactic acid bacteria (LAB)","volume":"39","author":"Naidu","year":"1999","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2023062713061545200_bib55","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1080\/10408398.2018.1425977","article-title":"the effects of probiotics in lactose intolerance: a systematic review","volume":"59","author":"Oak","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2023062713061545200_bib56","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.3389\/fmicb.2019.03146","article-title":"Comparative analysis of Lactobacillus gasseri and Lactobacillus crispatus isolated from human urogenital and gastrointestinal tracts","volume":"10","author":"Pan","year":"2020","journal-title":"Front Microbiol"},{"key":"2023062713061545200_bib57","first-page":"e07045","article-title":"Updated list of QPS-recommended biological agents for safety risk assessments carried out by EFSA","volume":"20","author":"Panel","year":"2022","journal-title":"EFSA J"},{"key":"2023062713061545200_bib58","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.lwt.2014.03.003","article-title":"Novel isolates of lactobacilli from fermented Portuguese olive as potential probiotics","volume":"59","author":"Peres","year":"2014","journal-title":"LWT - Food Science and Technology"},{"key":"2023062713061545200_bib59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.idairyj.2009.07.003","article-title":"Angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effect of fermented milk","volume":"20","author":"Pihlanto","year":"2010","journal-title":"Int Dairy J"},{"key":"2023062713061545200_bib60","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1080\/10408398.2015.1068736","article-title":"Production of angiotensin I converting enzyme inhibitory (ACE-I) peptides during milk fermentation and their role in reducing hypertension","volume":"57","author":"Rai","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2023062713061545200_bib61","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.lwt.2017.05.055","article-title":"Identification, characterization, and probiotic potential of Lactobacillus rhamnosus isolated from human milk","volume":"84","author":"Rajoka","year":"2017","journal-title":"LWT"},{"key":"2023062713061545200_bib62","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.lwt.2009.06.022","article-title":"Influence of addition of Raftiline HP\u00ae on the growth, proteolytic, ACE-and \u03b1-glucosidase inhibitory activities of selected lactic acid bacteria and bifidobacterium","volume":"43","author":"Ramchandran","year":"2010","journal-title":"LWT - Food Science and Technology"},{"key":"2023062713061545200_bib63","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1742-1241.1998.tb08916.x","article-title":"Management of hypertension and its sequelae with ACE inhibitors: biochemical, pharmacological and clinical aspects","volume":"52","author":"Rangoonwala","year":"1998","journal-title":"Int J Clinical Practice"},{"key":"2023062713061545200_bib64","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1051\/dst\/2010009","article-title":"Fermented milks from Enterococcus faecalis TH563 and Lactobacillus delbrueckii subsp. Bulgaricus LA2 manifest different degrees of ACE-inhibitory and immunomodulatory activities","volume":"90","author":"Regazzo","year":"2010","journal-title":"Dairy Sci Technol"},{"key":"2023062713061545200_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anaerobe.2014.07.004","article-title":"in vitro evaluation of the probiotic and functional potential of Lactobacillus strains isolated from fermented food and human intestine","volume":"30","author":"Ren","year":"2014","journal-title":"Anaerobe"},{"key":"2023062713061545200_bib66","doi-asserted-by":"crossref","first-page":"106227","DOI":"10.1016\/j.mimet.2021.106227","article-title":"a rapid screening method to evaluate acidifying activity by lactic acid bacteria","volume":"185","author":"Ribeiro","year":"2021","journal-title":"J Microbiol Methods"},{"key":"2023062713061545200_bib67","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/jam.12388","article-title":"Technological properties of bacteriocin-producing lactic acid bacteria isolated from Pico cheese an artisanal cow's milk cheese","volume":"116","author":"Ribeiro","year":"2014","journal-title":"J Appl Microbiol"},{"key":"2023062713061545200_bib68","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.lwt.2017.12.065","article-title":"Conjugated linoleic acid production and probiotic assessment of Lactobacillus plantarum isolated from Pico cheese","volume":"90","author":"Ribeiro","year":"2018","journal-title":"LWT"},{"key":"2023062713061545200_bib69","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0378-1135(02)00356-5","article-title":"Interaction between probiotic lactic acid bacteria and canine enteric pathogens: a, risk factor for intestinal Enterococcus faecium colonization?","volume":"92","author":"Rinkinen","year":"2003","journal-title":"Vet Microbiol"},{"key":"2023062713061545200_bib70","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1017\/S0007114509993801","article-title":"the effects of probiotic and conventional yoghurt on lipid profile in women","volume":"103","author":"Sadrzadeh-Yeganeh","year":"2010","journal-title":"Br J Nutr"},{"key":"2023062713061545200_bib71","doi-asserted-by":"crossref","first-page":"125260","DOI":"10.1016\/j.foodchem.2019.125260","article-title":"Identification and quantification of natural compounds produced by antifungal bioprotective cultures in dairy products","volume":"301","author":"Salas","year":"2019","journal-title":"Food Chem"},{"key":"2023062713061545200_bib72","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fgene.2014.00406","article-title":"the human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations","volume":"5","author":"Salazar","year":"2014","journal-title":"Front Genet"},{"key":"2023062713061545200_bib73","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev.food.080708.100743","article-title":"Food formats for effective delivery of probiotics","volume":"1","author":"Sanders","year":"2010","journal-title":"Annu Rev Food Sci Technol"},{"key":"2023062713061545200_bib74","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/10408398.2017.1383355","article-title":"Health benefits of fermented foods","volume":"59","author":"\u015eanlier","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2023062713061545200_bib75","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1399-3038.2005.00207.x","article-title":"Bacterial counts of intestinal Lactobacillus species in infants with colic","volume":"16","author":"Savino","year":"2005","journal-title":"Pediatr Allergy Immunol"},{"key":"2023062713061545200_bib76","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.3168\/jds.2015-9420","article-title":"Short communication: latin-style fresh cheese enhances lactic acid bacteria survival but not Listeria monocytogenes resistance under in vitro simulated gastrointestinal conditions","volume":"98","author":"Silva","year":"2015","journal-title":"J Dairy Sci"},{"key":"2023062713061545200_bib77","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.fm.2015.05.012","article-title":"Impact of non-starter lactobacilli on release of peptides with angiotensin-converting enzyme inhibitory and antioxidant activities during bovine milk fermentation","volume":"51","author":"Solieri","year":"2015","journal-title":"Food Microbiol"},{"key":"2023062713061545200_bib78","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.lwt.2017.07.018","article-title":"Potential probiotic Lactobacillus plantarum Ln4 from kimchi: evaluation of \u03b2-galactosidase and antioxidant activities","volume":"85","author":"Son","year":"2017","journal-title":"LWT - Food Science and Technology"},{"key":"2023062713061545200_bib79","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10068-017-0212-1","article-title":"Probiotic lactic acid bacteria isolated from traditional Korean fermented foods based on \u03b2-glucosidase activity","volume":"27","author":"Son","year":"2018","journal-title":"Food Sci Biotechnol"},{"key":"2023062713061545200_bib80","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.alit.2017.07.010","article-title":"Development of the gut microbiota in infancy and its impact on health in later life","volume":"66","author":"Tanaka","year":"2017","journal-title":"Allergology International"},{"key":"2023062713061545200_bib81","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.micres.2015.06.011","article-title":"Expression of bacteriocin LsbB is dependent on a transcription terminator","volume":"179","author":"Uzelac","year":"2015","journal-title":"Microbiol Res"},{"key":"2023062713061545200_bib82","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41586-018-0620-2","article-title":"the human gut microbiome in early-onset type 1 diabetes from the TEDDY study","volume":"562","author":"Vatanen","year":"2018","journal-title":"Nature"},{"key":"2023062713061545200_bib83","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.vetimm.2016.01.003","article-title":"Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species","volume":"172","author":"Vlasova","year":"2016","journal-title":"Vet Immunol Immunopathol"},{"key":"2023062713061545200_bib84","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1080\/19490976.2020.1760711","article-title":"Human milk microbiota development during lactation and its relation to maternal geographic location and gestational hypertensive status","volume":"11","author":"Wan","year":"2020","journal-title":"Gut Microbes"},{"key":"2023062713061545200_bib85","article-title":"Critically important antimicrobials for human medicine","volume-title":"6th revision","author":"WHO","year":"2019"},{"key":"2023062713061545200_bib86","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.3389\/fmicb.2016.01683","article-title":"Probiotic properties of Lactobacillus plantarum RYPR1 from an indigenous fermented beverage Raabadi","volume":"7","author":"Yadav","year":"2016","journal-title":"Front Microbiol"},{"key":"2023062713061545200_bib87","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/jam.12524","article-title":"Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli","volume":"117","author":"Yang","year":"2014","journal-title":"J Appl Microbiol"},{"key":"2023062713061545200_bib88","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res"},{"key":"2023062713061545200_bib89","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.numecd.2020.12.023","article-title":"the effect of probiotic fermented milk products on blood lipid concentrations: a systematic review and meta-analysis of randomized controlled trials","volume":"31","author":"Ziaei","year":"2021","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2023062713061545200_bib90","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1128\/AEM.03028-14","article-title":"Exopolysaccharide production and ropy phenotype are determined by two gene clusters in putative probiotic strain Lactobacillus paraplantarum BGCG11","volume":"81","author":"Zivkovic","year":"2015","journal-title":"Appl Environ Microbiol"}],"container-title":["Journal of Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jambio\/advance-article-pdf\/doi\/10.1093\/jambio\/lxad122\/50574601\/lxad122.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/134\/6\/lxad122\/50722694\/lxad122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/134\/6\/lxad122\/50722694\/lxad122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T13:07:33Z","timestamp":1687871253000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jambio\/article\/doi\/10.1093\/jambio\/lxad122\/7194246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,1]]},"references-count":90,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jambio\/lxad122","relation":{},"ISSN":["1365-2672"],"issn-type":[{"value":"1365-2672","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,6,1]]},"article-number":"lxad122"}}