{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:56:54Z","timestamp":1791975414562,"version":"4.4.0"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["14-16-00140"],"award-info":[{"award-number":["14-16-00140"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Gut bacteria play an important role in poultry nutrition and the immune defense system. Changes in the intestinal microbiome affect the physiological state, metabolism, and innate immunity of poultry. The present study aimed to characterize age-related changes in the gastrointestinal tract microflora in broiler chickens, depending on supplementation of the diet with the in-feed antibiotic Stafac\u00ae 110 and a Bacillus subtilis strain-based probiotic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In this regard, a comprehensive analysis of the taxonomic structure of the microbial community in the gastrointestinal tract (GIT) of broiler chickens was carried out using a molecular genetic technique of the terminal-restriction fragment length polymorphism analysis and taking into account age dynamics and feeding treatment. A beneficial effect on the microbiological composition and body weight of broilers was observed when using the antibiotic and probiotic in compound feeds. Different bacterial communities were revealed in the duodenum and cecum, and their positive impact on broiler growth was established. The results obtained shed light on the formation of GIT microflora of broiler chickens during the growing period and its changes in response to the use of the antibiotic and the probiotic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We suggest that the implementation of the tested in-feed antibiotic and probiotic can be beneficial in regulating the intestinal microflora microbiological processes in the GIT and improving the feeding efficiency and productivity of broiler chickens.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jambio\/lxad213","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T07:28:33Z","timestamp":1694849313000},"source":"Crossref","is-referenced-by-count":35,"title":["Probiotics as an alternative to antibiotics in modulating the intestinal microbiota and performance of broiler chickens"],"prefix":"10.1093","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-0454","authenticated-orcid":false,"given":"Alena A","family":"Grozina","sequence":"first","affiliation":[{"name":"Federal Scientific Center \u201cAll-Russia Research and Technological Poultry Institute\u201d, Russian Academy of Sciences , Sergiev Posad, Moscow Oblast 141311 , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-4844","authenticated-orcid":false,"given":"Larisa A","family":"Ilina","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Educational Institution of Higher Education \u201cSt. Petersburg State Agrarian University\u201d , Pushkin, St. Petersburg 196601 , Russia"},{"name":"BIOTROF LLC , Pushkin, St. Petersburg 196602 , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-6659","authenticated-orcid":false,"given":"Georgiy Yu","family":"Laptev","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Educational Institution of Higher Education \u201cSt. Petersburg State Agrarian University\u201d , Pushkin, St. Petersburg 196601 , Russia"},{"name":"BIOTROF LLC , Pushkin, St. Petersburg 196602 , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5846-5105","authenticated-orcid":false,"given":"Elena A","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Educational Institution of Higher Education \u201cSt. Petersburg State Agrarian University\u201d , Pushkin, St. Petersburg 196601 , Russia"},{"name":"BIOTROF LLC , Pushkin, St. Petersburg 196602 , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-8273","authenticated-orcid":false,"given":"Ekaterina S","family":"Ponomareva","sequence":"additional","affiliation":[{"name":"BIOTROF LLC , Pushkin, St. Petersburg 196602 , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8789-9837","authenticated-orcid":false,"given":"Valentina A","family":"Filippova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Educational Institution of Higher Education \u201cSt. Petersburg State Agrarian University\u201d , Pushkin, St. Petersburg 196601 , Russia"},{"name":"BIOTROF LLC , Pushkin, St. Petersburg 196602 , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-2432","authenticated-orcid":false,"given":"Darya G","family":"Tyurina","sequence":"additional","affiliation":[{"name":"BIOTROF LLC , Pushkin, St. Petersburg 196602 , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0081-6336","authenticated-orcid":false,"given":"Vladimir I","family":"Fisinin","sequence":"additional","affiliation":[{"name":"Federal Scientific Center \u201cAll-Russia Research and Technological Poultry Institute\u201d, Russian Academy of Sciences , Sergiev Posad, Moscow Oblast 141311 , Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-6052","authenticated-orcid":false,"given":"Ivan I","family":"Kochish","sequence":"additional","affiliation":[{"name":"K. 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