{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:29:27Z","timestamp":1772760567730,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The main objective of this study was to compare extended-spectrum \u03b2-lactamase (ESBL) Escherichia coli fecal titers during 12\u2009days between two groups: mice who received proton pump inhibitors (PPIs) and those that did not.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We tested three different in vivo models: model 1, high inoculum (106\u2009CFU ml\u22121); model 2, low inoculum (102\u2009CFU ml\u22121); and model 3, low inoculum and 2-day amoxicillin wash-out. There was no significant difference between the two groups in fecal ESBL E. coli titers in models 1 and 2. The fecal titers of ESBL E. coli were probably too high to show differences in colonization related to PPI treatment. By introducing a 2-day wash-out period after stopping amoxicillin (model 3), the fecal ESBL E. coli titers were higher in the PPI-treated mice during 12\u2009days (3 log versus 11 log day CFU g\u22121; P\u00a0&amp;lt;\u00a00.05). This result highlighted that PPIs promote stable ESBL E. coli digestive carriage in mice. Fecal quantitative PCR showed that mice with low ESBL E. coli fecal titers had a much higher concentration of equol-producing bacteria, Muribaculum sp., and Adlercreutzia caecimuris.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Pantoprazole treatment promotes sustained digestive carriage of ESBL E. coli in amoxicillin-treated mice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxad223","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T21:13:33Z","timestamp":1695762813000},"source":"Crossref","is-referenced-by-count":2,"title":["Pantoprazole promotes sustained intestinal carriage of multidrug-resistant <i>Escherichia coli<\/i> in amoxicillin-treated mice"],"prefix":"10.1093","volume":"134","author":[{"given":"Camille","family":"Moaligou","sequence":"first","affiliation":[{"name":"Cibles et m\u00e9dicaments des infections et de 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