{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:07Z","timestamp":1787009047439,"version":"build-2736575974"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100011749","name":"Pontificia Universidad Cat\u00f3lica del Ecuador","doi-asserted-by":"publisher","award":["QINV0213-IINV533010100"],"award-info":[{"award-number":["QINV0213-IINV533010100"]}],"id":[{"id":"10.13039\/501100011749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011749","name":"Pontificia Universidad Cat\u00f3lica del Ecuador","doi-asserted-by":"publisher","award":["MIC-012"],"award-info":[{"award-number":["MIC-012"]}],"id":[{"id":"10.13039\/501100011749","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to examine antibiotic resistance and the epidemiology of extended-spectrum \u03b2-lactamases (ESBL)-producing Escherichia coli associated with bloodstream infections over a period of 10 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Isolates were collected from January 2009 to December 2019 and those testing for E. coli were included. Antibiotic susceptibility was tested using the VITEK\u00ae system. Selected isolates were further characterized by amplification of marker genes (virulence traits, phylogroups, and sequence types). A total of 166 ESBL-producing E. coli were recovered. The blaCTX-M-15 allele was the most abundant. Most of the isolates were resistant to ceftriaxone, cefepime, ceftazidime, ampicillin\/sulbactam, piperacillin\/tazobactam, and ciprofloxacin. No resistance to carbapenems was registered. More than 80% of bacteria were classified as extraintestinal pathogenic E. coli (ExPEC), and the combination of virulence traits:papA-papC-kpsMII-uitA was the most common. Phylogroup B2 was the most prevalent, and bacteria predominantly belonged to ST131.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was an increase in the ExPEC ESBL-E coli in bloodstream infections and the relationship between the isolates found in these infections during these 10 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jambio\/lxad269","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T17:31:52Z","timestamp":1700069512000},"source":"Crossref","is-referenced-by-count":9,"title":["Dominance of ST131, B2,\n                    <i>bla<\/i>\n                    CTX-M-15, and\n                    <i>papA<\/i>\n                    -\n                    <i>papC<\/i>\n                    -\n                    <i>kpsMII<\/i>\n                    -\n                    <i>uitA<\/i>\n                    among ESBL\n                    <i>Escherichia coli<\/i>\n                    isolated from bloodstream infections in Quito, Ecuador: a 10-year surveillance study (2009\u20132019)"],"prefix":"10.1093","volume":"134","author":[{"given":"Jeannete","family":"Zurita","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Pontificia Universidad Cat\u00f3lica del Ecuador , Quito 170525 , Ecuador"},{"name":"Unidad de Investigaciones en Biomedicina, Zurita & Zurita Laboratorios , Quito 170104 , Ecuador"},{"name":"Servicio de Microbiolog\u00eda y Tuberculosis, Hospital Vozandes , Quito 170521 , Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Sevillano","sequence":"additional","affiliation":[{"name":"Unidad de Investigaciones en Biomedicina, Zurita & Zurita Laboratorios , Quito 170104 , 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Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iliana","family":"Alcocer","sequence":"additional","affiliation":[{"name":"Escuela de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica del Ecuador , Quito 170525 , Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ortega-Paredes","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias M\u00e9dicas Enrique Ortega Moreira, Carrera de Medicina, Universidad Esp\u00edritu Santo , Km 2.5 v\u00eda a Samborond\u00f3n 0901952 , Ecuador"},{"name":"Unidad de Investigaci\u00f3n en Enfermedades Transmitidas por Alimentos y Resistencia a los, Antimicrobianos (UNIETAR), Facultad de Veterinaria, Universidad Central del Ecuador , Quito 170129 , Ecuador"},{"name":"Laboratorio de Referencia de E. coli, Department of Microbiology and Parasitology, Veterinary Faculty, University of Santiago de Compostela , Lugo 15782 , 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