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For the identification of ARG, comprehensive antibiotic resistance database (CARD), and ResFinder were used. Gene conservation and evolution were investigated using DnaSP v.6. The transfer potential of the plasmids was evaluated using oriTfinder and a MOB-based phylogenetic tree was reconstructed using Fastree. We identified a total of 1064 ARGs in all plasmids analyzed, conferring resistance to 15 groups of antibiotics, mostly aminoglycosides, beta-lactams, and sulfonamides. The greatest number of ARGs per plasmid was found in enterobacteria from chicken feces. Plasmids from Escherichia coli carrying multiple ARGs were found in all ecosystems. Some of the most abundant genes were shared among all ecosystems, including aph(6)-Id, aph(3\u2032\u2019)-Ib, tet(A), and sul2. A high level of sequence conservation was found among these genes, and tet(A) and sul2 are under positive selective pressure. Approximately 62% of the plasmids carrying at least one ARG were potentially transferable. Phylogenetic analysis indicated a potential co-evolution of Enterobacteriaceae plasmids in nature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The high abundance of Enterobacteriaceae plasmids from diverse ecosystems carrying ARGs reveals their widespread distribution and importance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae028","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T09:55:41Z","timestamp":1707299741000},"source":"Crossref","is-referenced-by-count":10,"title":["Unraveling the diversity and dissemination dynamics of antimicrobial resistance genes in <i>Enterobacteriaceae<\/i> plasmids across diverse ecosystems"],"prefix":"10.1093","volume":"135","author":[{"given":"Yasmin Neves Vieira","family":"Sabino","sequence":"first","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Dias","family":"de\u00a0Melo","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giarl\u00e3 Cunha","family":"da\u00a0Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilario Cuquetto","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"},{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , 53706, Madison, WI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"2024022314524092400_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijantimicag.2013.04.017","article-title":"The tetA gene decreases tigecycline sensitivity of Salmonella enterica isolates","volume":"42","author":"Akiyama","year":"2013","journal-title":"Int J Antimicrob Agents"},{"key":"2024022314524092400_bib2","first-page":"D517","article-title":"CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database","volume":"48","author":"Alcock","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2024022314524092400_bib3","first-page":"1531","article-title":"a novel disrupted mcr-1 gene and a lysogenized phage P1-like sequence detected from a large conjugative plasmid, cultured from a human atypical enteropathogenic Escherichia coli (aEPEC) recovered in China","volume":"72","author":"Bai","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"2024022314524092400_bib4","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1093\/nar\/29.12.2607","article-title":"GeneMarkS: a self-training method for prediction of gene starts in microbial genomes. 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