{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:55:07Z","timestamp":1788753307024,"version":"build-2803163510"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002781","name":"University of Calcutta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>This study aimed to isolate, endophytic Streptomyces sp. MSARE05 isolated from root of a peanut (Arachis hypogaea) inhibits the growth of other bacteria. The research focused on characterizing the strain and the antimicrobial compound.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>The surface-sterilized peanut roots were used to isolate the endophytic bacterium Streptomyces sp. MSARE05. A small-scale fermentation was done to get the antimicrobial compound SM05 produced in highest amount in ISP-2 medium (pH 7) for 7 days at 30\u00b0C in shaking (180\u00a0rpm) condition. Extraction, purification, and chemical analysis of the antibacterial component revealed a novel class of antibiotics with a 485.54 Dalton molecular weight. The MIC was 0.4\u20130.8\u00a0\u00b5g ml\u22121 against the tested pathogens. It also inhibits multidrug-resistant (MDR) pathogens and Mycobacterium with 0.8\u20133.2\u00a0\u00b5g ml\u22121 MIC. SM05 was found to disrupt cell membrane of target pathogen as evident by significant leakage of intracellular proteins and nucleic acids. It showed synergistic activity with ampicillin, chloramphenicol, streptomycin, and kanamycin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The new-class antimicrobial SM05 consisting naphthalene core moiety was effective against drug-resistant pathogens but non-cytotoxic to human cells. This study underscores the significance of endophytic Streptomyces as a source of innovative antibiotics, contributing to the ongoing efforts to combat antibiotic resistance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae051","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T06:14:14Z","timestamp":1709187254000},"source":"Crossref","is-referenced-by-count":9,"title":["Endophytic <i>Streptomyces<\/i> sp. MSARE05 isolated from roots of Peanut plant produces a novel antimicrobial compound"],"prefix":"10.1093","volume":"135","author":[{"given":"Md Majharul","family":"Islam","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Bacteriology, Department of Microbiology, University of Calcutta , 35, Ballygunge Circular Road, Kolkata 700019 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrabani","family":"Saha","sequence":"additional","affiliation":[{"name":"The Molecular Recognition Laboratory, Department of Chemistry, Visva-Bharati University , Siksha Bhavana, Santiniketan, Birbhum 731235 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8493-7068","authenticated-orcid":false,"given":"Prithidipa","family":"Sahoo","sequence":"additional","affiliation":[{"name":"The Molecular Recognition Laboratory, Department of Chemistry, Visva-Bharati University , Siksha Bhavana, Santiniketan, Birbhum 731235 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7752-0982","authenticated-orcid":false,"given":"Sukhendu","family":"Mandal","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Bacteriology, Department of Microbiology, University of Calcutta , 35, Ballygunge Circular Road, Kolkata 700019 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"2024031315062741100_bib1","first-page":"335","article-title":"Stopping bacterial adhesion: a novel approach to treating infections","volume-title":"Respiration","author":"Bavington","year":"2005"},{"key":"2024031315062741100_bib2","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.celrep.2015.09.059","article-title":"Bactericidal antibiotics induce toxic metabolic perturbations that lead to cellular damage","volume":"13","author":"Belenky","year":"2015","journal-title":"Cell Rep"},{"key":"2024031315062741100_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ja.2012.54","article-title":"Thoughts and facts about antibiotics: where we are now and where we are heading","volume":"65","author":"B\u00e9rdy","year":"2012","journal-title":"J Antibiot (Tokyo)"},{"key":"2024031315062741100_bib4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1128\/AAC.12.2.163","article-title":"Effects of membrane-energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: a model for entry of streptomycin and gentamicin in susceptible and resistant bacteria","volume":"12","author":"Bryan","year":"1977","journal-title":"Antimicrob Agents Chemother"},{"key":"2024031315062741100_bib5","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1432-1033.1973.tb03020.x","article-title":"Bacterial-protein synthesis. 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