{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:05:16Z","timestamp":1790197516561,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["160034\/2021-3"],"award-info":[{"award-number":["160034\/2021-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309579\/2019-8"],"award-info":[{"award-number":["309579\/2019-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["009464\/2021-92"],"award-info":[{"award-number":["009464\/2021-92"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00772-19"],"award-info":[{"award-number":["APQ-00772-19"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ\u201401433-22"],"award-info":[{"award-number":["APQ\u201401433-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ\u201402899-18"],"award-info":[{"award-number":["APQ\u201402899-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>This study aimed to compare and characterize the resistance profile and the presence of extended-spectrum beta-lactamase (ESBL) related genes in Escherichia coli isolated from healthy finishing pigs fed with or without antibiotics in their diets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A total of 27 ceftiofur-resistant E. coli isolates were obtained from 96 healthy pigs. The antibiotic resistance profile was tested, and all 27 isolates were classified as multidrug-resistant (MDR). A high proportion of isolates were resistant to cephalosporins, ampicillin, ciprofloxacin, and tetracyclines. The ESBL production was observed in 85% of isolates by double-disc synergy test. The MDR-E. coli isolates harbored ESBL genes, such as blaTEM, blaCTX-M-1, blaCTX-M-2, and blaCTX-M-8,25. In addition, other antibiotics resistance genes (ARGs) were also detected, such as sul2, ant(3\u2033)-I, tetA, and mcr-1. The mobilization of the blaCTX-M gene was confirmed for nine E. coli isolates by conjugation assays. The presence of blaCTX-M on mobile genetic elements in these isolates was demonstrated by Southern blot hybridization, and the resistance to cephalosporins was confirmed in the transconjugants. Our results indicate the prevalence of CTX-M-producing E. coli strains harboring mobile genetic elements in the normal microbiota of healthy pigs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings highlight the significance of ESBL genes as a global health concern in livestock and the potential spread of antimicrobial resistance to other members of the gastrointestinal tract microbiota.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae058","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T06:58:49Z","timestamp":1709708329000},"source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and characteristics of ESBL-producing <i>Escherichia coli<\/i> in clinically healthy pigs: implications for antibiotic resistance spread in livestock"],"prefix":"10.1093","volume":"135","author":[{"given":"R\u00fazivia Pimentel","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"},{"name":"Laboratory of Molecular Genetics of Bacteria, Instituto de Biotecnologia Aplicada \u00e0 Agropecu\u00e1ria (Bioagro), Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Soares","family":"da\u00a0Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giarl\u00e3 Cunha","family":"da\u00a0Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5496-429X","authenticated-orcid":false,"given":"J\u00e9ssica Nogueira","family":"Rosa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Mara Soares","family":"Bazzolli","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"},{"name":"Laboratory of Molecular Genetics of Bacteria, Instituto de Biotecnologia Aplicada \u00e0 Agropecu\u00e1ria (Bioagro), Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilario C","family":"Mantovani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Universidade Federal de Vi\u00e7osa , 36570-900 Vi\u00e7osa, Minas Gerais , Brazil"},{"name":"Department of Animal and Dairy Sciences, University of Wisconsin-Madison , 53706, Madison, WI , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"2024040117562926000_bib1","doi-asserted-by":"crossref","first-page":"20140085","DOI":"10.1098\/rstb.2014.0085","article-title":"The livestock reservoir for antimicrobial resistance: a personal view on changing patterns of risks, effects of interventions and the way forward","volume":"370","author":"Aarestrup","year":"2015","journal-title":"Phil Trans R Soc B"},{"key":"2024040117562926000_bib2","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1038\/s41396-018-0200-3","article-title":"Dissemination and persistence of extended-spectrum cephalosporin-resistance encoding IncI1- blaCTX-M-1 plasmid among Escherichia coli in pigs","volume":"12","author":"Abraham","year":"2018","journal-title":"ISME J"},{"key":"2024040117562926000_bib4","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1089\/mdr.2019.0247","article-title":"Antibiotic treatment administered to pigs and antibiotic resistance of Escherichia coli isolated from their feces and carcasses","volume":"26","author":"Bacci","year":"2020","journal-title":"Microb Drug Resist"},{"key":"2024040117562926000_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1556\/004.2021.00036","article-title":"Occurrence of Escherichia coli producing extended spectrum \u03b2-lactamases in food-producing animals","volume":"69","author":"Bal\u00e1zs","year":"2021","journal-title":"Acta Vet Hung"},{"key":"2024040117562926000_bib6","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.2147\/IDR.S371845","article-title":"Extended-spectrum beta-lactamases producing Escherichia coli in South America: a systematic review with a one health perspective","volume":"15","author":"Bastidas-Caldes","year":"2022","journal-title":"Infect Drug Resist"},{"key":"2024040117562926000_bib7","doi-asserted-by":"crossref","first-page":"e11300","DOI":"10.15252\/msb.202211300","article-title":"Vertical and horizontal gene transfer tradeoffs direct plasmid fitness","volume":"19","author":"Bethke","year":"2023","journal-title":"Mol Syst Biol"},{"key":"2024040117562926000_bib10","article-title":"Instru\u00e7\u00e3o Normativa No 01","author":"Brazil Minist\u00e9rio Da Agricultura, Pecu\u00e1ria E Abastecimento (MAPA)","year":"2020"},{"key":"2024040117562926000_bib8","article-title":"Instru\u00e7\u00e3o Normativa No 45","author":"Brazil Minist\u00e9rio Da Agricultura, Pecu\u00e1ria E Abastecimento (MAPA)","year":"2016"},{"key":"2024040117562926000_bib9","article-title":"Plano de A\u00e7\u00e3o Nacional de Preven\u00e7\u00e3o e Controle da Resist\u00eancia aos Antimicrobianos no \u00e2mbito da Agropecu\u00e1ria (PAN-BR AGRO) 1\u00b0 edi\u00e7\u00e3o","author":"Brazil Minist\u00e9rio Da Agricultura, Pecu\u00e1ria E Abastecimento (MAPA)","year":"2018"},{"key":"2024040117562926000_bib11","doi-asserted-by":"crossref","first-page":"e00047","DOI":"10.1128\/CMR.00047-19","article-title":"Epidemiology of \u03b2-lactamase-producing pathogens","volume":"33","author":"Bush","year":"2020","journal-title":"Clin Microbiol Rev"},{"key":"2024040117562926000_bib12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.prevetmed.2012.03.001","article-title":"Prophylactic and metaphylactic antimicrobial use in Belgian fattening pig herds","volume":"106","author":"Callens","year":"2012","journal-title":"Prev Vet Med"},{"key":"2024040117562926000_bib77_754_112624","article-title":"Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated from Animals","volume-title":"Clinical and Laboratory Standards Institute","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2023","edition":"6th ed"},{"key":"2024040117562926000_bib78_224_113024","article-title":"Performance Standards for Antimicrobial Susceptibility Testing","volume-title":"Wayne, PA: Clinical and Laboratory Standards Institute","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2020","edition":"30th ed"},{"key":"2024040117562926000_bib15","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3390\/microorganisms9040881","article-title":"Antimicrobial use in Brazilian Swine Herds: assessment of use and reduction examples","volume":"9","author":"Dutra","year":"2021","journal-title":"Microorganisms"},{"key":"2024040117562926000_bib16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jgar.2019.03.011","article-title":"Multidrug-resistant Escherichia coli harboring mcr-1 and blaCTX-M genes isolated from swine in Argentina","volume":"18","author":"Faccone","year":"2019","journal-title":"J Glob Antimicrob Resist"},{"key":"2024040117562926000_bib17","doi-asserted-by":"crossref","first-page":"105802","DOI":"10.1016\/j.ijantimicag.2019.09.006","article-title":"Occurrence of CTX-M-15 and MCR-1-producing Enterobacterales in pigs, Portugal; evidence of direct links with antibiotic selective pressure","volume":"55","author":"Fournier","year":"2019","journal-title":"J Antimicrob Agents"},{"key":"2024040117562926000_bib18","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrmicro1235","article-title":"Mobile genetic elements: the agents of open source evolution","volume":"3","author":"Frost","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"2024040117562926000_bib19","doi-asserted-by":"crossref","first-page":"1042612","DOI":"10.3389\/fmicb.2022.1042612","article-title":"Mobile colistin resistance (MCR), extended-spectrum beta-lactamase (ESBL) and multidrug resistance monitoring in Escherichia coli (commensal and pathogenic) in pig farming: need of harmonized guidelines and clinical breakpoints","volume":"13","author":"Garc\u00eda","year":"2022","journal-title":"Front Microbiol"},{"key":"2024040117562926000_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1574891X09666140608145307","article-title":"Beta-lactamase and carbapenemase detection methods: an overview of recent patents","volume":"9","author":"Georgios","year":"2014","journal-title":"Recent Pat Antiinfect Drug Discov"},{"key":"2024040117562926000_bib76_730_114324","first-page":"9","article-title":"Past: Paleontological Statistics Software Package for Education and Data Analysis","volume-title":"Palaeontologia Electronica, v. 4, n. 1","author":"Hammer","year":"2001"},{"key":"2024040117562926000_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1089\/fpd.2015.2017","article-title":"Molecular characterization of \u03b2-lactamase-producing Escherichia coli collected from 2001 to 2011 from pigs in Korea","volume":"13","author":"Han","year":"2016","journal-title":"Foodborne Pathog Dis"},{"key":"2024040117562926000_bib24","first-page":"1","article-title":"Genetic determinants of resistance to extended-spectrum cephalosporin and fluoroquinolone in Escherichia coli isolated from diseased pigs in the United States","volume":"5","author":"Hayer","year":"2020","journal-title":"Msystems"},{"key":"2024040117562926000_bib29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijantimicag.2017.10.004","article-title":"Integrons in Enterobacteriaceae: diversity, distribution and epidemiology","volume":"51","author":"Kaushik","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"2024040117562926000_bib30","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1128\/AAC.00107-16","article-title":"Global dissemination of blaKPC into bacterial species beyond Klebsiella pneumoniae and in vitro susceptibility to ceftazidime-avibactam and aztreonam-avibactam","volume":"60","author":"Kazmierczak","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2024040117562926000_bib31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ijfoodmicro.2011.01.003","article-title":"Distribution and transferability of tetracycline resistance determinants in Escherichia coli isolated from meat and meat products","volume":"145","author":"Koo","year":"2011","journal-title":"Int J Food Microbiol"},{"key":"2024040117562926000_bib34","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.scitotenv.2019.02.079","article-title":"Future global pig production systems according to the shared socioeconomic pathways","volume":"665","author":"Lassaletta","year":"2019","journal-title":"Sci Total Environ"},{"key":"2024040117562926000_bib35","doi-asserted-by":"crossref","first-page":"710747","DOI":"10.3389\/fmicb.2021.710747","article-title":"Prevalence, characteristics and clonal distribution of extended-spectrum \u03b2-lactamase- and AmpC \u03b2-lactamase-producing Escherichia coli following the swine production stages, and potential risks to humans","volume":"12","author":"Lee","year":"2021","journal-title":"Front Microbiol"},{"key":"2024040117562926000_bib36","doi-asserted-by":"crossref","first-page":"113655","DOI":"10.1016\/j.ecoenv.2022.113655","article-title":"Profiles of antibiotic- and heavy metal-related resistance genes in animal manure revealed using a metagenomic analysis","volume":"239","author":"Liu","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"key":"2024040117562926000_bib37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.vetmic.2018.08.005","article-title":"Characterization of plasmids harboring blaCTX-M genes in Escherichia coli from French pigs","volume":"224","author":"Lucas","year":"2018","journal-title":"Vet Microbiol"},{"key":"2024040117562926000_bib38","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2147\/IDR.S235975","article-title":"Carbapenem-resistant Klebsiella aerogenes clinical isolates from a teaching hospital in southwestern China: detailed molecular epidemiology, resistance determinants, risk factors and clinical outcomes","volume":"13","author":"Ma","year":"2020","journal-title":"Infect Drug Resist"},{"key":"2024040117562926000_bib85_766_121524","first-page":"268","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume-title":"Clin Microbiol Infect","author":"Magiorakos","year":"2012"},{"key":"2024040117562926000_bib73_355_112124","first-page":"795","article-title":"Antibiotic use in agriculture and its consequential resistance in environmental sources: Potential public health implications","volume-title":"Molecules","author":"Manyi-Loh","year":"2018"},{"key":"2024040117562926000_bib39","first-page":"e00433","article-title":"Complete genome sequence of Escherichia coli J53, an azide-resistant laboratory strain used for conjugation experiments","volume":"6","author":"Matsumura","year":"2018","journal-title":"Genome Announc"},{"key":"2024040117562926000_bib40","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1292\/jvms.20-0338","article-title":"Association between antimicrobial treatment and resistance of pathogenic Escherichia coli isolated from diseased swine in Kagoshima","volume":"83","author":"Misumi","year":"2021","journal-title":"J Vet Med Sci"},{"key":"2024040117562926000_bib41","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1128\/microbiolspec.VMBF-0016-2015","article-title":"Mechanisms of antibiotic resistance","volume":"4","author":"Munita","year":"2016","journal-title":"Microbiol Spectr"},{"key":"2024040117562926000_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-13192-3","article-title":"Antibiotic resistant Escherichia coli from diarrheic piglets from pig farms in Thailand that harbor colistin-resistant mcr genes","volume":"12","author":"Nguyet","year":"2022","journal-title":"Sci Rep"},{"key":"2024040117562926000_bib43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jgar.2018.01.007","article-title":"Molecular characterization of blaOXA-48 carbapenemase-, extended-spectrum \u03b2-lactamase- and Shiga toxin-producing Escherichia coli isolated from farm piglets in India","volume":"13","author":"Nirupama","year":"2018","journal-title":"J Glob Antimicrob Resist"},{"key":"2024040117562926000_bib45","volume-title":"OIE List of Antimicrobial Agents of Veterinary Importance","author":"OIE","year":"2018."},{"key":"2024040117562926000_bib46","doi-asserted-by":"crossref","first-page":"40","DOI":"10.17756\/jfcn.2020-082","article-title":"Use of antibiotics in animal production and its impact on human health","volume":"6","author":"Oliveira","year":"2020","journal-title":"J Food Chem Nanotechnol"},{"key":"2024040117562926000_bib47","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1135(02)00028-7","article-title":"Detection and identification of Salmonella from poultry-related samples by PCR","volume":"87","author":"Oliveira","year":"2002","journal-title":"Vet Microbiol"},{"key":"2024040117562926000_bib48","doi-asserted-by":"crossref","first-page":"108629","DOI":"10.1016\/j.vetmic.2020.108629","article-title":"Epidemic spread of IncI1\/pST113 plasmid carrying the extended-spectrum beta-lactamase (ESBL) blaCTX-M-8 gene in Escherichia coli of Brazilian cattle","volume":"243","author":"Palmeira","year":"2020","journal-title":"Vet Microbiol"},{"key":"2024040117562926000_bib49","doi-asserted-by":"crossref","first-page":"e00088","DOI":"10.1128\/CMR.00088-17","article-title":"Mobile genetic elements associated with antimicrobial resistance","volume":"31","author":"Partridge","year":"2018","journal-title":"Clin Microbiol Rev"},{"key":"2024040117562926000_bib51","first-page":"1","article-title":"Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China","volume":"13","author":"Peng","year":"2022","journal-title":"Nat Commun"},{"key":"2024040117562926000_bib54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13613-015-0061-0","article-title":"Mechanisms of antimicrobial resistance in Gram-negative bacilli","volume":"5","author":"Rupp\u00e9","year":"2015","journal-title":"Ann Intensive Care"},{"key":"2024040117562926000_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/microorganisms9010195","article-title":"Genomic features of MCR-1 and extended-spectrum \u03b2-lactamase-producing Enterobacterales from retail raw chicken in Egypt","volume":"9","author":"Sadek","year":"2021","journal-title":"Microorganisms"},{"key":"2024040117562926000_bib57","first-page":"276","article-title":"Antibiotic usage patterns in selected broiler farms of Bangladesh and their public health implications","volume":"2","author":"Saiful\u00a0Islam","year":"2016","journal-title":"J Public Health Dev Ctries"},{"key":"2024040117562926000_bib58","doi-asserted-by":"crossref","first-page":"e0138173","DOI":"10.1371\/journal.pone.0138173","article-title":"Analysis of transmission of MRSA and ESBL-E among pigs and farm personnel","volume":"10","author":"Schmithausen","year":"2015","journal-title":"PLoS One"},{"key":"2024040117562926000_bib60","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1128\/AAC.02788-15","article-title":"First characterization of CTX-M-15-producing Escherichia coli strains belonging to sequence type (ST) 410, ST224, and ST1284 from commercial swine in South America","volume":"60","author":"Silva","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2024040117562926000_bib81_725_111124","first-page":"1","article-title":"Genetic environment of blaTEM-1, blaCTX-M-15, blaCMY-42 and characterization of integrons of Escherichia coli isolated from an Indian urban aquatic environment","volume-title":"Front Microbiol","author":"Singh","year":"2018"},{"key":"2024040117562926000_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-06415-0","article-title":"Plasmid-mediated colistin resistance and ESBL production in Escherichia coli from clinically healthy and sick pigs","volume":"12","author":"Trongjit","year":"2022","journal-title":"Sci Rep"},{"key":"2024040117562926000_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fvets.2021.659222","article-title":"Genetic characterization of CTX-M-2-producing Klebsiella pneumoniae and Klebsiella oxytoca associated with bovine mastitis in Japan","volume":"8","author":"Tsuka","year":"2021","journal-title":"Front Vet Sci"},{"key":"2024040117562926000_bib67","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1073\/pnas.1503141112","article-title":"Global trends in antimicrobial use in food animals","volume":"112","author":"Van\u00a0Boeckel","year":"2015","journal-title":"P Natl Acad Sci USA"},{"key":"2024040117562926000_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2015.01103","article-title":"Prevalence and characteristics of extended-spectrum \u03b2-lactamase genes in Escherichia coli isolated from piglets with post-weaning diarrhea in Heilongjiang province, China","volume":"6","author":"Xu","year":"2015","journal-title":"Front Microbiol"},{"key":"2024040117562926000_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4102\/ojvr.v88i1.1880","article-title":"Analysis of antibiotic resistance phenotypes and genes of Escherichia coli from healthy swine in guizhou, China","volume":"88","author":"Yu","year":"2021","journal-title":"Onderstepoort J Vet Res"},{"key":"2024040117562926000_bib72","first-page":"369","article-title":"CTX-M-producing Escherichia coli in pigs from a Czech farm during the production cycle","volume":"71","author":"Zelendova","year":"2020","journal-title":"Lett Appl Microbiol"},{"key":"2024040117562926000_bib75_958_112624","first-page":"1","article-title":"A novel structure harboring blaCTX-M-27 on IncF plasmids in Escherichia coli isolated from swine in China","volume-title":"Antibiotics","author":"Zhang","year":"2021"}],"container-title":["Journal of Applied Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jambio\/advance-article-pdf\/doi\/10.1093\/jambio\/lxae058\/56874052\/lxae058.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/135\/4\/lxae058\/57135731\/lxae058.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jambio\/article-pdf\/135\/4\/lxae058\/57135731\/lxae058.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T17:57:11Z","timestamp":1711994231000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jambio\/article\/doi\/10.1093\/jambio\/lxae058\/7623021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,5]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jambio\/lxae058","relation":{},"ISSN":["1365-2672"],"issn-type":[{"value":"1365-2672","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,3,5]]},"article-number":"lxae058"}}