{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:50:46Z","timestamp":1787727046713,"version":"build-2784847793"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Bal\u0131kesir University Scientific Research Projects","award":["BAP: 2021-091"],"award-info":[{"award-number":["BAP: 2021-091"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>In this study, it was aimed to examine the antibacterial activity of the essential oil components (EOCs), carvacrol (CAR), cinnamaldehyde (CIN), thymol (TH), alpha pinene (\u03b1-PN), eucalyptol (EU), limonene (LIM), and the antibiotics, linezolid (LZD), vancomycin (VAN), gentamicin (GEN), ciprofloxacin (CIP), clindamycin (CLN), and penicillin (PEN) against 50 multidrug resistant Corynebacterium striatum strains, and the synergistic interactions of CAR and CIN with the antibiotics against 10 randomly selected Coryne. striatum strains to explore synergistic interactions to determine if their combined use could enhance antibiotic activity and potentially reduce resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The activity of the EOCs and the antibiotics against Coryne. striatum strains isolated from clinical specimens, was examined by broth microdilution method. The synergistic interactions of the EOCs with the antibiotics against 10 randomly selected Coryne. striatum strains were determined by checkerboard method. EOCs, CIN, and CAR and antibiotics, LZD, VAN, GEN, CIP, and CLN were detected to have antibacterial activity against Coryne. striatum strains alone and either synergistic interactions were observed in combinations of the antibiotics with EOCs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>All Coryne. striatum strains were determined to be susceptible to VAN and LZD and resistant to GEN, PEN, CIP, and CLN. Synergistic interactions were observed in all combinations of antibiotics tested with CAR and CIN.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae090","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T17:24:23Z","timestamp":1712597063000},"source":"Crossref","is-referenced-by-count":9,"title":["Synergistic interactions of essential oil components with antibiotics against multidrug-resistant <i>Corynebacterium striatum<\/i>"],"prefix":"10.1093","volume":"135","author":[{"given":"Umut","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Medical Microbiology, Balikesir University , Balikesir 10145 , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet G\u00f6khan","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Food Hygiene and Technology, Uluda\u011f University , Bursa , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yener","family":"\u00d6zel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Microbiology, Balikesir University , Balikesir 10145 , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8023-2976","authenticated-orcid":false,"given":"Mehmet","family":"\u00dcnl\u00fc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Microbiology, Balikesir University , Balikesir 10145 , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-7849","authenticated-orcid":false,"given":"G\u00fclhan","family":"Vardar-\u00fcnl\u00fc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Microbiology, Balikesir University , Balikesir 10145 , T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"2024042508555010300_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/0970-258X.326750","article-title":"Corynebacterium striatum: an emerging nosocomial skin and soft-tissue pathogen","volume":"34","author":"Agrawal","year":"2021","journal-title":"Natl Med J Ind"},{"key":"2024042508555010300_bib2","article-title":"In vitro antibacterial effects of Salvia sclarea, Eucalyptus Globulus and Eugenia caryophyllata essential oils against multidrug resistant Corynebacterium spp clinical isolates","volume":"2","author":"Alibi","year":"2020","journal-title":"J Clin Res Rep"},{"key":"2024042508555010300_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.retram.2020.01.001","article-title":"Anti-oxidant, antibacterial, anti-biofilm, and anti-quorum sensing activities of four essential oils against multidrug-resistant bacterial clinical isolates","volume":"68","author":"Alibi","year":"2020","journal-title":"Curr Res Translat Med"},{"key":"2024042508555010300_bib4","doi-asserted-by":"crossref","first-page":"9704","DOI":"10.1038\/s41598-017-10081-y","article-title":"Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital","volume":"7","author":"Alibi","year":"2017","journal-title":"Sci Rep"},{"key":"2024042508555010300_bib5","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3390\/pathogens9020136","article-title":"Antimicrobial resistance and molecular epidemiology of Corynebacterium striatum isolated in a tertiary hospital in Turkey","volume":"9","author":"Asgin","year":"2020","journal-title":"Pathogens"},{"key":"2024042508555010300_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1590\/S0074-02762013000100004","article-title":"Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil","volume":"108","author":"Baio","year":"2013","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2024042508555010300_bib7","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3390\/antibiotics11111617","article-title":"Synergistic action of Cinnamomum verum essential oil with sertraline","volume":"11","author":"Barbarossa","year":"2022","journal-title":"Antibiotics"},{"key":"2024042508555010300_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0956-7135(03)00028-8","article-title":"Antibacterial activity and composition of essential oils from Origanum, Thymbra and Satureja species with commercial importance in Turkey","volume":"15","author":"Baydar","year":"2004","journal-title":"Food Control"},{"key":"2024042508555010300_bib9","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1080\/10412905.2005.9698965","article-title":"Composition and antimicrobial activity of essential oil of Satureja montanal. 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