{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:43:11Z","timestamp":1790451791723,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Uriach"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The present study is a single-centre, randomized, controlled clinical trial aimed to evaluate the effectiveness of the probiotic Lacticaseibacillus rhamnosus TOM 22.8 (DSM 33500) strain, orally administrated, to treat vaginal dysbiosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>Overall, 80 women, with signs and symptoms of vaginal dysbiosis, were enrolled and allocated to the treatment group (A, n=60), who took 1 capsule of the probiotic strain for 10 consecutive days, or the non-treatment group (B, n=20), who did not receive any treatment. Clinical (vaginal signs and symptoms; pH of the vaginal fluid; Amsel criteria; Nugent score; Lactobacillary grade) and microbiological examinations were performed at baseline (T0), 10 days (T1), and 30 (T2) days after the oral administration of the probiotic TOM 22.8 strain. The latter resulted in a restoration of the physiological pH, accompanied by remission or attenuation of clinical signs and symptoms as well as the improvement of the quality of life (QoL). Microbiological data revealed a significant reduction of potentially pathogenic bacteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The administration of the L. rhamnosus TOM 22.8 probiotic strain could be proposed as an effective strategy for the treatment of vaginal dysbiosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae110","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T14:07:39Z","timestamp":1715782059000},"source":"Crossref","is-referenced-by-count":8,"title":["<i>Lacticaseibacillus rhamnosus<\/i> TOM 22.8 (DSM 33500) is an effective strategy for managing vaginal dysbiosis, rising the lactobacilli population"],"prefix":"10.1093","volume":"135","author":[{"given":"Amanda","family":"Vaccalluzzo","sequence":"first","affiliation":[{"name":"Department of Agriculture, Food and Environment, University of Catania , Santa Sofia Street, 100, 95123 Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8246-106X","authenticated-orcid":false,"given":"Alessandra","family":"Pino","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food and Environment, University of Catania , Santa Sofia Street, 100, 95123 Catania , Italy"},{"name":"ProBioEtna SRL, Spin off of the University of Catania , Santa Sofia Street, 100, 95123 Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaela Luisa","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties, University of Catania , Santa Sofia Street, 78, 95123 Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Caggia","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food and Environment, University of Catania , Santa Sofia Street, 100, 95123 Catania , Italy"},{"name":"ProBioEtna SRL, Spin off of the University of Catania , Santa Sofia Street, 100, 95123 Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cianci","sequence":"additional","affiliation":[{"name":"Unit of Gynecology and Obstetrics, Department of Human Pathology of Adult and Childhood \u201cG. Barresi\u201d, University of Messina , 98122 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia Lucia","family":"Randazzo","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Food and Environment, University of Catania , Santa Sofia Street, 100, 95123 Catania , Italy"},{"name":"ProBioEtna SRL, Spin off of the University of Catania , Santa Sofia Street, 100, 95123 Catania , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"2024051708554683000_bib1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0002-9343(83)91112-9","article-title":"Nonspecific vaginitis. 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