{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:53:26Z","timestamp":1789419206283,"version":"build-2803163510"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SERB-EMR\/2017\/000254"],"award-info":[{"award-number":["SERB-EMR\/2017\/000254"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Isolation, identification, structural and functional characterization of potent anti-Candida compound with specific antagonistic activities against significant human pathogens, Candida albicans and C. auris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>The compound (55B3) was purified from the metabolites produced by Streptomyces chrestomyceticus ADP4 by employing column chromatography. The structure of 55B3 was determined from the analyses of spectral data that included LCMS, nuclear magnetic resonance, FTIR, and UV spectroscopies. It was identified as a novel derivative of diterpenic aromatic acid, 3-(dictyotin-11\u2032-oate-15\u2032\u03b1, 19\u2032\u03b2-olide)-4-(dictyotin-11\u2032-oate-15\u2033\u03b1, 19\u2033\u03b2-olide)-protocatechoic acid. The compound displayed potent antifungal and anti-biofilm activities against C. albicans ATCC 10231 (Minimum Inhibitory Concentration, MIC90:14.94\u00a0\u00b1\u00a00.17 \u03bcgmL\u22121 and MBIC90: 16.03\u00a0\u00b1\u00a01.1 \u03bcgmL\u22121) and against C. auris CBS 12372 (MIC90: 21.75\u00a0\u00b1\u00a01.5 \u03bcgmL\u22121 and Minimum Biofilm Inhibitory Concentration, MBIC90: 18.38\u00a0\u00b1\u00a01.78 \u03bcgmL\u22121). Further, pronounced inhibition of important virulence attributes of Candida spp., e.g. yeast-to-hyphae transition, secretory aspartyl proteinase and phospholipase B by 55B3 was noted at subinhibitory concentrations. A plausible mechanism of anti-Candida action of the compound appeared to be the inhibition of ergosterol biosynthesis, which was inhibited by 64\u00a0\u00b1\u00a03% at the MIC90 value. The non-cytotoxic attribute of the compound was noted in the liver cell line (HepG2 cells).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present work led to the discovery of a novel diterpenic derivative produced by S. chrestomyceticus ADP4. The compound displayed potent anti-Candida activity, particularly against the two most significant human pathogens, C. albicans and C. auris, which underlined its significance as a potential drug candidate for infections involving these pathogens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jambio\/lxae139","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T04:51:07Z","timestamp":1718081467000},"source":"Crossref","is-referenced-by-count":11,"title":["A novel diterpenic derivative produced by\n                    <i>Streptomyces chrestomyceticus<\/i>\n                    ADP4 is a potent inhibitor of biofilm and virulence factors in\n                    <i>Candida albicans<\/i>\n                    and\n                    <i>C. auris<\/i>"],"prefix":"10.1093","volume":"135","author":[{"given":"Radha","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Biological Sciences and Engineering, Netaji Subhas University of Technology , New Delhi 110078 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Engineering, Netaji Subhas University of Technology , New Delhi 110078 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Ali","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Hamdard University , New Delhi 110062 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-7260","authenticated-orcid":false,"given":"Ashok K","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences and Engineering, Netaji Subhas University of Technology , New Delhi 110078 , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"2024061908552176200_bib1","doi-asserted-by":"crossref","first-page":"e561298","DOI":"10.3389\/fmicb.2020.561298","article-title":"Inhibitory effect of morin against Candida albicans pathogenicity and virulence factor production: an in vitro and in vivo approaches","volume":"11","author":"Abirami","year":"2020","journal-title":"Front Microbiol"},{"key":"2024061908552176200_bib2","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.2147\/IDR.S249864","article-title":"Candida auris: from multidrug resistance to pan-resistant strains","volume":"13","author":"Ademe","year":"2020","journal-title":"Infect Drug Resist"},{"key":"2024061908552176200_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.micpath.2009.10.001","article-title":"Evolution of ergosterol biosynthesis inhibitors as fungicidal against 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