{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:57:06Z","timestamp":1791899826257,"version":"4.3.4"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"PROPESQ\/UFPE","award":["06\/2022"],"award-info":[{"award-number":["06\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study aimed to investigate the presence of beta-lactams resistance genes and the clonal relationship of clinical isolates of Enterobacterales obtained from patients with and without COVID-19, in a hospital in northeastern Brazil.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The study analyzed 45 carbapenem-resistant clinical isolates using enterobacterial repetitive intergenic consensus (ERIC-PCR), PCR, and amplicon sequencing to detect resistance genes (blaKPC, blaGES, blaNDM, blaVIM, and blaIMP). The main species were Klebsiella pneumoniae, Serratia marcescens, and Proteus mirabilis. Detected genes included blaNDM (46.66%), blaKPC (35.55%), and both (17.79%). ERIC-PCR showed multiclonal dissemination and high genetic variability. The main resistance gene was blaNDM, including blaNDM-5 and blaNDM-7.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The presence of Enterobacterales carrying blaKPC and blaNDM in this study, particularly K. pneumoniae, in infections and colonizations of patients with COVID-19 and non-COVID-19, highlights genetic variability and resistance to carbapenems observed in multiple species of this order.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae212","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T02:39:08Z","timestamp":1723689548000},"source":"Crossref","is-referenced-by-count":5,"title":["Occurrence of <i>bla<\/i>NDM-1, <i>bla<\/i>NDM-5, <i>bla<\/i>NDM-7, and <i>bla<\/i>KPC-2 genes in clinical isolates of <i>enterobacterales<\/i> with high genetic variability, from colonization and infection in patients with or without COVID-19, from a hospital in Brazil"],"prefix":"10.1093","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-4626","authenticated-orcid":false,"given":"Lamartine Rodrigues","family":"Martins","sequence":"first","affiliation":[{"name":"Universidade Federal de Pernambuco, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical , Recife, PE, 50670-901 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Izabely Silva","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical , Recife, PE, 50670-901 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-3460","authenticated-orcid":false,"given":"\u00c9rica Maria","family":"de\u00a0Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical , Recife, PE, 50670-901 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moacir Batista","family":"Juc\u00e1","sequence":"additional","affiliation":[{"name":"Secretaria Estadual de Sa\u00fade de Pernambuco , Recife, PE, 50751-530 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Maria Bispo","family":"Beltr\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical , Recife, PE, 50670-901 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-108X","authenticated-orcid":false,"given":"Ana Catarina de Souza","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Medicina Tropical , Recife, PE, 50670-901 , Brasil"},{"name":"Universidade Federal de Pernambuco, Centro de Ci\u00eancias 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