{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:30:00Z","timestamp":1783189800099,"version":"3.54.6"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172959"],"award-info":[{"award-number":["32172959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Beyond the pivotal roles of the gut microbiome in initiating physiological processes and modulating genetic factors, a query persists: Can a single gene mutation alter the abundance of the gut microbiome community? Not only this, but the intricate impact of gut microbiome composition on skin pigmentation has been largely unexplored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Based on these premises, our study examines the abundance of lipase-producing gut microbes about differential gene expression associated with bile acid synthesis and lipid metabolism-related blood metabolites in red (whole wild) and white (whole white wild and SCARB1\u2212\/\u2212 mutant) Oujiang colour common carp. Following the disruption of the SCARB1 gene in the resulting mutant fish with white body colour (SCARB1\u2212\/\u2212), there is a notable decrease in the abundance of gut microbiomes (Bacillus, Staphylococcus, Pseudomonas, and Serratia) associated with lipase production. This reduction parallels the downregulation seen in wild-type white body colour fish (WW), as contrasting to the wild-type red body colour fish (WR). Meanwhile, in SCARB1\u2212\/\u2212 fish, there was a downregulation noted not only at the genetic and metabolic levels but also a decrease in lipase-producing bacteria. This consistency with WW contrasts significantly with WR. Similarly, genes involved in the bile acid synthesis pathway, along with blood metabolites related to lipid metabolism, exhibited downregulation in SCARB1\u2212\/\u2212 fish.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The SCARB1 knockout gene blockage led to significant alterations in the gut microbiome, potentially influencing the observed reduction in carotenoid-associated skin pigmentation. Our study emphasizes that skin pigmentation is not only impacted by genetic factors but also by the gut microbiome. Meanwhile, the gut microbiome\u2019s adaptability can be rapidly shaped and may be driven by specific single-gene variations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae226","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T04:53:16Z","timestamp":1725684796000},"source":"Crossref","is-referenced-by-count":8,"title":["Specific gut microbiome\u2019s role in skin pigmentation: insights from <i>SCARB1<\/i> mutants in Oujiang colour common carp"],"prefix":"10.1093","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0049-9473","authenticated-orcid":false,"given":"Nusrat Hasan","family":"Kanika","sequence":"first","affiliation":[{"name":"Key Laboratory of Freshwater Aquatic Genetic Resources Certificated by the Ministry of Agriculture and Rural Affairs, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University , Shanghai 201306 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-0736","authenticated-orcid":false,"given":"Xin","family":"Hou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Aquatic Genetic Resources Certificated by the Ministry of Agriculture and Rural Affairs, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University , Shanghai 201306 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Aquatic Genetic Resources Certificated by the Ministry of Agriculture and Rural Affairs, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University , Shanghai 201306 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Aquatic Genetic Resources Certificated by the Ministry of Agriculture and Rural Affairs, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University , Shanghai 201306 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-3316","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Aquatic Genetic Resources Certificated by the Ministry of Agriculture and Rural Affairs, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University , Shanghai 201306 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-7610","authenticated-orcid":false,"given":"Chenghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Aquatic Genetic Resources Certificated by the Ministry of Agriculture and Rural Affairs, National Demonstration Centre for Experimental Fisheries Science Education, Shanghai Engineering Research Center of Aquaculture, Shanghai Ocean University , Shanghai 201306 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"2024091312441093500_bib1","doi-asserted-by":"publisher","first-page":"103416","DOI":"10.1016\/j.jff.2019.103416","article-title":"Host-microbiome interactions in response to a high-saturated fat diet and fish-oil supplementation in zebrafish adult","volume":"60","author":"Arias-Jayo","year":"2019","journal-title":"J Funct Foods"},{"key":"2024091312441093500_bib2","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"B\u00e4ckhed","year":"2005","journal-title":"Science"},{"key":"2024091312441093500_bib3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nature18849","article-title":"Interactions between the microbiota and pathogenic bacteria in the gut","volume":"535","author":"Ba\u00fcmler","year":"2016","journal-title":"Nature"},{"key":"2024091312441093500_bib4","doi-asserted-by":"publisher","first-page":"858064","DOI":"10.3389\/fmicb.2022.858064","article-title":"Eukaryogenesis: the rise of an emergent superorganism","volume":"13","author":"Bell","year":"2022","journal-title":"Front Microbiol"},{"key":"2024091312441093500_bib5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1136\/gut.42.1.2","article-title":"Ecological control of the gastrointestinal tract. 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