{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:24:38Z","timestamp":1782224678474,"version":"3.54.5"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Natural Science Fund Basic Research Program of Shaanxi Province","award":["2022JM-500"],"award-info":[{"award-number":["2022JM-500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study aimed to investigate the antibacterial and anti-inflammatory effects of the antimicrobial peptide Microcin C7 for Porphyromonas gingivalis-associated diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Reverse-phase high-performance liquid chromatography revealed that Microcin C7 could remain 25.5% at 12\u2009h in saliva. At a concentration of &amp;lt;10\u2009mg\u2009ml\u20131, Microcin C7 showed better cytocompatibility, as revealed by a hemolysis test and a subchronic systemic toxicity test. Moreover, the minimum inhibitory concentration and minimum bactericidal concentration of Microcin C7 were analyzed using a broth microdilution method, bacterial growth curve, scanning electron microscopy, and confocal laser microscopy and determined to be 0.16 and 5\u2009mg\u2009ml\u20131, respectively. Finally, in a rat model, 5\u2009mg\u2009ml\u20131 Microcin C7 showed better performance in decreasing the expression of inflammatory factors (IL-1\u03b2, IL-6, IL-8, and TNF-\u03b1) and alveolar bone resorption than other concentrations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Microcin C7 demonstrated favorable biocompatibility, antibacterial activity, and anti-inflammatory effect, and could decrease the alveolar bone resorption in a rat model, indicating the promising potential for clinical translation and application on P. gingivalis-associated diseases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae247","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T03:38:32Z","timestamp":1727753912000},"source":"Crossref","is-referenced-by-count":3,"title":["The antimicrobial peptide Microcin C7 inhibits the growth of 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