{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:26:10Z","timestamp":1763018770548,"version":"3.41.2"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Salmonellosis, a major global cause of diarrheal diseases, significantly impacts the intestinal microbiome. Probiotic-rich beverages, such as kefir, are increasingly utilized as alternative health-promoting beverages associated with various microbiota benefits. This study investigated the repercussions of daily consumption of household-produced milk kefir on Salmonella enterica serovar Typhimurium infection in C57BL-6 mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Kefir consumption pre-infection reduced the presence of inflammatory cells in the colon and altered the cytokine profile by reducing IL-10 and increasing IFN-\u03b3. Despite reducing intestinal inflammation, kefir intake did not yield a prompt response to an acute infection caused by the aggressive pathogen Salmonella. This contributed to increased mortality in the mice, evidenced by higher fecal Salmonella counts post-infection. Metabarcoding analysis demonstrated that the use of kefir before infection increases butyric acid by the higher abundance of Lachnospiraceae and Prevotellaceae families and genus in feces, coupled with an increase in Muribaculaceae family and Bacteroides genus among infected kefir-treated mice. While kefir hinted at microbiota alterations reducing enterobacteria (Helicobacter), decrease IL-10, and increased IFN-\u03b3, butyric acid on pre-infection, the beverage potentially facilitated the systemic translocation of pathogens, intensifying the infection\u2019s severity by altering the immune response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The use of kefir in the dosage of 10%\u00a0w\/v (109 CFU), for acute infections with Salmonella Typhimurium, may not be enough to combat the infection and worsen the prognosis, leaving the intestine less inflamed, favoring the replication and translocation of the pathogen. These findings underscore the importance of prudently evaluating the widespread use of probiotics and probiotic-rich beverages, especially during acute infections, given their potential association with adverse effects during these diseases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae249","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T02:46:17Z","timestamp":1727232377000},"source":"Crossref","is-referenced-by-count":1,"title":["Daily intake of household-produced milk kefir on <i>Salmonella<\/i> Typhimurium infection in C57BL\/6 mice: mortality, microbiota modulation, and immunological implications"],"prefix":"10.1093","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2136-4447","authenticated-orcid":false,"given":"Mariana de F\u00e1tima","family":"Albuquerque\u00a0Pereira","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health, Universidade Federal de Vi\u00e7osa (UFV) , Av. P.H. Rolfs, s\/n., 36570-900, Vi\u00e7osa, Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Gabriela","family":"Morais\u00a0de\u00a0\u00c1vila","sequence":"additional","affiliation":[{"name":"Institute of Biological Science - Interunit Postgraduate Program in Bioinformatics, Universidade Federal de Minas Gerais (UFMG) , Av. 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Rolfs, s\/n., 36570-900, Vi\u00e7osa, Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordana","family":"Macedo\u00a0Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Universidade Federal de Vi\u00e7osa , UFV. Av. P.H. Rolfs, s\/n., 36570-900, Vi\u00e7osa, Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Campos\u00a0Silva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Universidade Federal de Vi\u00e7osa , UFV. Av. P.H. Rolfs, s\/n., 36570-900, Vi\u00e7osa, Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananda","family":"Pereira\u00a0Aguilar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Universidade Federal de Vi\u00e7osa , UFV. Av. P.H. Rolfs, s\/n., 36570-900, Vi\u00e7osa, Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4353-7011","authenticated-orcid":false,"given":"Leandro Licursi","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of General Biology, Universidade Federal de Vi\u00e7osa (UFV) , Av. P.H. Rolfs, s\/n., 36570-900, Vi\u00e7osa, Minas Gerais ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reggiani","family":"Vilela\u00a0Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Universidade Federal de Vi\u00e7osa (UFV) , Av. P.H. 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