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Light and fluorescence microscopy revealed drastic cell lysis of S. aureus treated with Bp-1AdE. Scanning and transmission electron microscopy suggested that Bp-1AdE disrupts the cytoplasmic membrane. Toxicity assays showed that Bp-1AdE was non-toxic to Tenebrio molitor larvae. Liquid chromatography-mass spectrometry and Global Natural Product Social spectral libraries identified four substances within Bp-1AdE, including aliphatic alcohols [3,4-dipentylhexane-2,5-diol and 1,1\u2032-(4,5-dibutyl-3,6-dimethylcyclohexane-1,2-diyl)bis(ethan-1-one)] and terpenoids (cholic acid and canrenone).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Bp-1AdE demonstrated selective toxicity and bactericidal activity, highlighting its potential for controlling infections caused by multidrug-resistant S. aureus strains.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae260","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T02:50:08Z","timestamp":1728960608000},"source":"Crossref","is-referenced-by-count":2,"title":["Marine <i>Bacillus pumilus<\/i> substances exhibit antimicrobial effect on multidrug-resistant <i>Staphylococcus aureus<\/i>"],"prefix":"10.1093","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-1233","authenticated-orcid":false,"given":"J\u00e9ssyca","family":"Freitas-Silva","sequence":"first","affiliation":[{"name":"Instituto de Microbiologia Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro , Av. 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