{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:03:35Z","timestamp":1753877015810,"version":"3.41.2"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008134","name":"California State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008134","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Cupriavidus isolates are found in environmental and clinical samples and are often resistant to carbapenems, which are last-resort antibiotics. However, their carbapenem-resistance molecular mechanisms remain unknown. This study aimed to (i) characterize and sequence the carbapenem-resistant soil isolate Cupriavidus taiwanensis S2-1-W to uncover its antibiotic resistance determinants; and (ii) clone and characterize a putative novel carbapenemase gene identified in this isolate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Antibiotic susceptibility testing of C. taiwanensis S2-1-W revealed that it was resistant to most carbapenems, other \u03b2-lactams, and aminoglycosides tested. Genome sequencing of this isolate revealed a complex chromosomal resistome that included multidrug efflux pump genes, one aminoglycoside transferase gene, and three \u03b2-lactamase genes. Among them, we identified a novel putative class D \u03b2-lactamase gene (blaOXA-1206) that is highly conserved among other sequenced C. taiwanensis isolates. Cloning and characterization of blaOXA-1206 confirmed that it encodes for a newly discovered carbapenemase (OXA-1206) that confers resistance to carbapenems and other \u03b2-lactams.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Carbapenem-resistance in C. taiwanensis S2-1-W is associated with a newly discovered carbapenemase, OXA-1206.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxae265","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T02:49:08Z","timestamp":1729219748000},"source":"Crossref","is-referenced-by-count":2,"title":["Resistance to carbapenems in the urban soil isolate <i>Cupriavidus taiwanensis<\/i> S2-1-W is associated with OXA-1206, a newly discovered carbapenemase"],"prefix":"10.1093","volume":"135","author":[{"given":"Nicolas V","family":"Lopez","sequence":"first","affiliation":[{"name":"Department of Biology, California State University Northridge , Northridge, CA 91330 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-5180","authenticated-orcid":false,"given":"Cristian","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Biology, California State University Northridge , Northridge, CA 91330 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"2024103014054449100_bib1","doi-asserted-by":"publisher","first-page":"e0292288","DOI":"10.1371\/journal.pone.0292288","article-title":"Decoding the genetic structure of conjugative plasmids in international clones of Klebsiella pneumoniae: a deep dive into blaKPC, blaNDM, blaOXA-48, and blaGES genes","volume":"18","author":"Aghamohammad","year":"2023","journal-title":"PLoS One"},{"key":"2024103014054449100_bib2","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"2024103014054449100_bib3","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1101\/gr.076448.108","article-title":"Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and comparative genomics of rhizobia","volume":"18","author":"Amadou","year":"2008","journal-title":"Genome Res"},{"key":"2024103014054449100_bib4","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3390\/ijms18040705","article-title":"Specificity in legume\u2013rhizobia symbioses","volume":"18","author":"Andrews","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2024103014054449100_bib5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. 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