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The association study revealed that combination therapy exhibited additive effects (0.5 &amp;lt; FICI &amp;lt; 1.0) when combined BAC with either amphotericin B or fluconazole. A time-growth assay confirmed that treatment with 35.29 \u03bcg\u2009ml\u22121 of BAC completely inhibited the growth of T. marneffei and exhibited antifungal effects. Micromorphological analysis using scanning electron microscopy and transmission electron microscopy photomicrographs revealed that BAC treatment induced morphological damage in fungal cells compared to the control group. Transmembrane protein assays showed a significant reduction in the levels of Na+\/K+-ATPase (P &amp;lt; .05) and Ca2+-ATPase (P &amp;lt; .01) compared to the control group. Intracellular enzyme assays demonstrated that BAC treatment significantly decreased ATP, malate dehydrogenase, and succinate dehydrogenase content (P &amp;lt; .01). The combination of proteomics and parallel reaction monitoring (PRM) verification indicated that BAC exhibits an antifungal mechanism against T. marneffei by downregulating ATP citric acid lyase (ACLY) levels , potentially affecting the tricarboxylic acid (TCA) cycle. Besides, the binding model of BAC and the ACLY also shows a good docking score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings suggest that BAC exhibits antifungal activity against T. marneffei, elucidating its multifaceted mechanism of action involving disruption of cell membranes\u2019 integrity and inhibition of intracellular enzyme activities, in which the modulation of ACLY in the TCA cycle may play an important role.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jambio\/lxae297","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T07:22:52Z","timestamp":1733210572000},"source":"Crossref","is-referenced-by-count":4,"title":["Antifungal activity of bamemacrolactine C against\n                    <i>Talaromyces marneffei<\/i>\n                    and its possible mechanisms of action"],"prefix":"10.1093","volume":"135","author":[{"given":"Cuiping","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Qu","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxi","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]},{"name":"Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghai","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi University of Chinese Medicine , No.13 Wuhe Road, Nanning 530200 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