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This study aims to provide a comprehensive overview of the global distribution of clinical mycoplasmas, elucidate their resistance to various antibiotics, and identify the genetic and molecular mechanisms underlying their resistance. A systematic review and meta-analysis were conducted, collating data from peer-reviewed publications between 2012 and 2024. The UK (100%) and Germany (98%) reported high numbers of respiratory mycoplasmas, with 7% and 2% being resistant to macrolides. For urogenital mycoplasmas, Iceland (99%) and Estonia (94%) reported a high prevalence of Mycoplasma species, whereas the UK (85%), France (82%), and the USA (82%) reported a high prevalence of Ureaplasma species. High resistance rates in Mycoplasma and Ureaplasma have been reported in Greenland (100%) and the UK (86%), respectively. The rising resistance rates in these species underscore an urgent need for updated treatment guidelines and the development of novel therapeutic options. Our findings highlight the importance of tailored antibiotic stewardship and the potential of genomic insights in guiding effective treatment strategies.<\/jats:p>","DOI":"10.1093\/jambio\/lxae308","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T02:41:36Z","timestamp":1735094496000},"source":"Crossref","is-referenced-by-count":14,"title":["Global prevalence, resistance rates, and underlying resistance mechanisms of clinical <i>Mycoplasma<\/i> and <i>Ureaplasma<\/i> species"],"prefix":"10.1093","volume":"136","author":[{"given":"Winnie Thabisa","family":"Ramaloko","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, University of KwaZulu-Natal , Durban 4000 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nontuthuko Excellent","family":"Maningi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Life Sciences, University of KwaZulu-Natal , Durban 4000 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Osei\u00a0Sekyere","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, University of Pretoria , Pretoria 0084 ,","place":["South Africa"]},{"name":"Institute of Biomarker Research, Medical Diagnostic Laboratories, Genesis Biotechnology Group , Hamilton Township, NJ 08690 ,","place":["United States"]},{"name":"Department of Clinical Development, Medical Diagnostic Laboratories, Genesis Biotechnology Group , Hamilton Township, NJ 08690 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"2025021416063566200_bib1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1002\/jgf2.201","article-title":"Clinical features and seasonal variations in the prevalence of macrolide-resistant 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