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The resistome and the mobile genetic elements associated with the spread of mcr-1.1 in Southern Brazil were also characterized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The 22 mcr-1.1-harboring E. coli isolates from different origins were selected for antimicrobial susceptibility testing and whole genome sequencing for characterization of the resistome, plasmids, and sequence types. All isolates presented several resistance genes and harbored the mcr-1.1 gene in a highly similar IncX4 plasmid. Furthermore, the mcr-1.1 gene co-occurred with the mcr-3.12 gene in a multidrug-resistant isolate from the farm environment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings demonstrate that the mcr-1.1 gene in E. coli isolates from Brazil is spreading mainly by horizontal transfer of the IncX4 plasmid. The co-occurrence of mcr-1.1 and mcr-3.12 highlights pig farming as an important reservoir of colistin resistance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxaf019","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T02:52:09Z","timestamp":1736909529000},"source":"Crossref","is-referenced-by-count":0,"title":["Resistome and plasmidome genomic features of <i>mcr-1.1<\/i>-harboring <i>Escherichia coli<\/i>: a <i>One Health<\/i> approach"],"prefix":"10.1093","volume":"136","author":[{"given":"Gabriela","family":"Sim\u00f5es\u00a0de\u00a0Oliveira","sequence":"first","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, Rio Grande do Sul, 90035-903 ,","place":["Brazil"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Rio Grande do Sul , Porto Alegre, Rio Grande do Sul, 90610-000 ,","place":["Brazil"]},{"name":"Laborat\u00f3rio de Microbiologia 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