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This study aimed to explore the therapeutic potential of antimicrobial peptidomimetics, specifically peptoids with sequence-specific N-substituted glycines, against ESKAPEE pathogens, including metallo-\u03b2-lactamase (MBL) producers, as well as C. auris strains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This study evaluated activity of the peptoids against the multidrug-resistant priority pathogens. The peptoid TM8 (with an N-decyl alkyl chain) demonstrated a geometric mean minimum inhibitory concentration (MIC) of 7.8\u00a0\u03bcg ml\u22121 against MBL-producing bacteria, and 5.5\u00a0\u03bcg ml\u22121 against C. auris. TM8 showed synergy with ciprofloxacin, enhancing its effectiveness 4-fold against NDM-1-producing Klebsiella pneumoniae. No antagonism was seen when TM8 was used with either conventional antibiotics or antifungals. Peptoids that had therapeutic indices below 3 were generally more hydrophobic, due to either alkyl chains or bromine. Scanning electron microscopy and live-dead staining assay on peptoid-treated C. auris confirmed morphological changes and killing activity, respectively. Furthermore, the peptoid could effectively inhibit biofilm formation by C. auris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peptoids demonstrated antibacterial activity against ESKAPEE, particularly against MBL-producing Gram-negative bacteria. Additionally, they exhibited antifungal and anti-biofilm activities against C. auris strains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jambio\/lxaf031","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T07:17:26Z","timestamp":1739171846000},"source":"Crossref","is-referenced-by-count":11,"title":["Antimicrobial activity of peptoids against Metallo-\u03b2-lactamase-producing\n                    <i>Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa<\/i>\n                    , and other WHO priority pathogens, including\n                    <i>Candida auris<\/i>"],"prefix":"10.1093","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-7319","authenticated-orcid":false,"given":"Shyam Kumar","family":"Mishra","sequence":"first","affiliation":[{"name":"School of Optometry and Vision Science, Faculty of Medicine and Health, University of New South Wales , Sydney, NSW 2052 ,","place":["Australia"]},{"name":"Department of Microbiology, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University , Kathmandu 44600 ,","place":["Nepal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Yasir","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science, Faculty of Medicine and Health, University of New South Wales , Sydney, NSW 2052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kuppusamy","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science, Faculty of Medicine and Health, University of New South Wales , Sydney, NSW 2052 ,","place":["Australia"]},{"name":"School of Chemistry, Faculty of Science, University of New South Wales , Sydney, NSW 2052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar H 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