{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:09:59Z","timestamp":1788923399415,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["21K09896"],"award-info":[{"award-number":["21K09896"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003182","name":"NOF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To prevent peri-implantitis, we investigated the adhesion of periodontopathogenic bacteria to titanium surfaces using a hydrophobic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer to inhibit adhesion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method and results<\/jats:title>\n                  <jats:p>We immersed titanium plates (TiPs) coated with a hydrophobic MPC polymer in a bacterial suspension for 30\u00a0min or 24\u00a0h and measured the number of adherent bacteria. Bacteria adhering to the TiPs were observed using scanning electron microscopy (SEM). Furthermore, mimicking an oral cavity, TiPs coated with MPC polymer and saliva, were immersed in bacterial suspensions of Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus mutans for 24\u00a0h, and adenosine triphosphate in the adherent bacteria was measured.<\/jats:p>\n                  <jats:p>Bacterial adhesion was significantly inhibited on MPC polymer-coated TiPs after 30\u00a0min and 24\u00a0h. SEM results showed a similar trend. Bacterial adhesion was significantly inhibited on MPC polymer-treated TiPs in the presence of saliva, both before and after MPC treatment. Furthermore, their effectiveness was maintained when the MPC polymer-treated TiPs were stored in saline for 1 week.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Hydrophobic MPC polymer coating on TiP surface inhibited bacterial adhesion, indicating that it may be effective in preventing peri-implantitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxaf033","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T09:23:56Z","timestamp":1739870636000},"source":"Crossref","is-referenced-by-count":3,"title":["Hydrophobic 2-methacryloyloxyethyl phosphorylcholine polymer inhibits peri-implantitis-causing bacterial adhesion on titanium materials"],"prefix":"10.1093","volume":"136","author":[{"given":"Minato","family":"Akizuki","sequence":"first","affiliation":[{"name":"Department of Periodontology and Endodontology, Graduate School of Biomedical Sciences, Tokushima University , Tokushima 770-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare , Kurashiki 701-0193 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumitsu","family":"Sekine","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Bioengineering, Graduate School of Biomedical Sciences, Tokushima University , Tokushima 770-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-3237","authenticated-orcid":false,"given":"Akikazu","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, Graduate School of Biomedical Sciences, Tokushima University , Tokushima 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,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Bioengineering, Graduate School of Biomedical Sciences, Tokushima University , Tokushima 770-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raras Ajeng","family":"Enggardipta","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Endodontology, Graduate School of Biomedical Sciences, Tokushima University , Tokushima 770-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology, Graduate School of Biomedical Sciences, Tokushima University , Tokushima 770-8504 ,","place":["Japan"]},{"name":"Department of Biology, Keio University School of Medicine , Yokohama 223-8521 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