{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T20:47:52Z","timestamp":1770497272682,"version":"3.49.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Health and Labor Sciences Research","award":["JP21KA1005"],"award-info":[{"award-number":["JP21KA1005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>This study aims to investigate the genomic profile of a multidrug-resistant Escherichia coli strain, 160-11H1, co-carrying an extended-spectrum \u03b2-lactamase (ESBL) and the plasmid-mediated mobile colistin resistance gene, mcr-5.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>The entire genome of the strain was sequenced using Illumina MiSeq and Oxford Nanopore platforms, and de novo assembly was performed using Unicycler. The genome size was 5\u2009031 330\u00a0bp and comprised 5140 coding sequences. mcr-5 and an ESBL-encoding gene, blaSHV-12, providing resistance to clinically important antimicrobials, including colistin (minimum inhibitory concentration [MIC]: 8\u00a0\u00b5g ml\u22121) and extended-spectrum cephalosporins (MIC: &amp;gt;32\u00a0\u00b5g ml\u22121) were detected. mcr-5 was carried on a Tn3-type transposase, being in an operon with a ChrB-domain protein and an uncharacterized major facilitator superfamily-type transporter on a conjugative plasmid of the IncFII backbone. The blaSHV-12 gene was inserted into tniA putative transposase gene in the IncFIA\/FIB\/FIC multireplicon plasmid. The strain belonged to sequence type (ST) 10, CH-type fumC11\/fimH54, serotype O4:H12, and phylogroup A, and carried several virulence genes associated with heat survival, colonization, fitness, and conjugation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study presents the first identification of polymyxin-resistant E. coli co-carrying mcr-5 and ESBL genes in meat from Japan, highlighting the critical need for routine investigations of these genes within food ecosystems.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxaf229","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T14:40:42Z","timestamp":1757515242000},"source":"Crossref","is-referenced-by-count":1,"title":["Genomic insights into multidrug-resistant extraintestinal pathogenic <i>Escherichia coli<\/i> O4:H12 harboring <i>mcr-5<\/i> and <i>bla<\/i>SHV-12 on conjugative plasmids isolated from chicken meat in Japan"],"prefix":"10.1093","volume":"136","author":[{"given":"Christian","family":"Xedzro","sequence":"first","affiliation":[{"name":"Laboratory of Food Microbiology and Hygiene, Graduate School of Integrated Sciences for Life, Hiroshima University , 1-4-4 Kagamiyama, Higashihiroshima 739-8528 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshi","family":"Shimamoto","sequence":"additional","affiliation":[{"name":"Laboratory of Food Microbiology and Hygiene, Graduate School of Integrated Sciences for Life, Hiroshima University , 1-4-4 Kagamiyama, Higashihiroshima 739-8528 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-7798","authenticated-orcid":false,"given":"Ashraf M","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Kafrelsheikh University Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, , Kafr El-Sheikh 33516 ,","place":["Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liansheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Research Center, National Institute of Infectious Disease, Japan Institute for Health Security , 4-2-1 Aoba-cho, Higashimurayama, Tokyo 189-0002 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yo","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Research Center, National Institute of Infectious Disease, Japan Institute for Health Security , 4-2-1 Aoba-cho, Higashimurayama, Tokyo 189-0002 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyuki","family":"Sugai","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance Research Center, National Institute of Infectious Disease, Japan Institute for Health Security , 4-2-1 Aoba-cho, 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