{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:54:18Z","timestamp":1790949258203,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Listeria monocytogenes is a foodborne pathogen found ubiquitously in the food manufacturing environment (FME), where exposure to biocides at sublethal concentrations may induce adaptation and cross-resistance. This study aimed to investigate whether exposure to sublethal benzalkonium chloride (BAC) concentrations induced cross-resistance to antibiotics in an adaptive laboratory evolution (ALE) model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Results<\/jats:title>\n                  <jats:p>Six L. monocytogenes and two Listeria innocua strains underwent a 30-day sublethal BAC ALE. Susceptibility was performed against biocides and antibiotics. Variant calling was performed relative to wild-type strains. Three intragenic mutations and two intergenic mutations upstream of fepR, encoding a local repressor of the fluoroquinolone efflux pump FepA are identified in BAC-adapted isolates, associated with phenotypic reduced susceptibility to BAC, fluoroquinolones, and co-trimoxazole.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Sublethal BAC exposure can select for fepR-associated variants linked to reduced susceptibility to both biocides and antibiotics, highlighting concerns for biocide-antibiotic cross-resistance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jambio\/lxaf241","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:53:32Z","timestamp":1758628412000},"source":"Crossref","is-referenced-by-count":2,"title":["Sublethal exposure to benzalkonium chloride induced biocide-antibiotic cross-resistance in hypervirulent <i>L. monocytogenes<\/i>"],"prefix":"10.1093","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-7923","authenticated-orcid":false,"given":"Joshua","family":"Macleod","sequence":"first","affiliation":[{"name":"Microbiology and Infection Research Group, School of Sport and Health Sciences, Cardiff Metropolitan University , Cardiff, CF5 2YB ,","place":["United Kingdom"]},{"name":"ZERO2FIVE Food Industry Centre, Llandaff Campus, Cardiff Metropolitan University , Cardiff, CF5 2YB ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zak","family":"Hamid","sequence":"additional","affiliation":[{"name":"Microbiology and Infection Research Group, School of Sport and Health Sciences, Cardiff Metropolitan University , Cardiff, CF5 2YB ,","place":["United Kingdom"]},{"name":"ZERO2FIVE Food Industry Centre, Llandaff Campus, Cardiff Metropolitan University , Cardiff, CF5 2YB ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin E","family":"Johns","sequence":"additional","affiliation":[{"name":"Food, Water & Environmental Laboratory, Microbiology Cardiff, Public Health Wales , Cardiff, CF64 2XX ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-0772","authenticated-orcid":false,"given":"Michael L","family":"Beeton","sequence":"additional","affiliation":[{"name":"Microbiology and Infection Research Group, School of Sport and Health Sciences, Cardiff Metropolitan University , Cardiff, CF5 2YB ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-5563","authenticated-orcid":false,"given":"James","family":"Blaxland","sequence":"additional","affiliation":[{"name":"Microbiology and Infection Research Group, School of Sport and Health Sciences, Cardiff Metropolitan University , 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