{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T18:57:24Z","timestamp":1764097044726,"version":"3.46.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100015828","name":"Science Education Institute, Department of Science and Technology, Republic of the Philippines","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Plant diseases caused by pathogenic microorganisms are among the major challenges in global agricultural production, necessitating the search for bioactive natural compounds with effective antimicrobial activity. This study investigates the potential of Lentinus tigrinus culture filtrate extract for the discovery of compounds active against agriculturally important pathogens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The culture filtrate of the mushroom L. tigrinus was subjected to bioassay-guided fractionation, leading to the isolation of five compounds. These were identified by mass spectrometry, nuclear magnetic resonance, and optical rotation analyses as (R)-mellein (1) and its derivatives: (R)-5-methoxycarbonylmellein (2), (3S,4S)-4-hydroxymellein (3), (3R,4S)-4-hydroxymellein (4), and (S)-8-O-methylmellein (5). All compounds were tested in vitro against four plant pathogenic fungi and four plant pathogenic bacteria. Compound 2 exhibited the strongest antifungal activity, particularly against Pyricularia oryzae, inhibiting conidial germination (IC\u2085\u2080 30.2\u00a0\u03bcM) and germ tube elongation (IC\u2085\u2080 20.7\u00a0\u03bcM). In vivo, compound 5 suppressed rice blast lesion symptoms caused by P. oryzae. Compound 1 showed the most potent antibacterial activity. Based on IC\u2085\u2080 values, all compounds were more effective against fungi than bacteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The inhibitory activities of the five isolated compounds against plant pathogenic fungi and bacteria suggest their potential as lead compounds for agrochemicals for managing plant diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jambio\/lxaf270","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:20:07Z","timestamp":1762212007000},"source":"Crossref","is-referenced-by-count":0,"title":["Mellein and its derivatives isolated from the basidiomycete mushroom\n                    <i>Lentinus tigrinus<\/i>\n                    exhibit inhibitory activity against plant pathogenic microorganisms"],"prefix":"10.1093","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2948-7740","authenticated-orcid":false,"given":"Enrico M","family":"Cabutaje","sequence":"first","affiliation":[{"name":"The United Graduate School of Agricultural Sciences, Tottori University , Tottori 680-8553 ,","place":["Japan"]},{"name":"Bioactive Natural Products Discovery Laboratory, Research Center for the Natural and Applied Sciences, University of Santo Tomas , Espan\u0303a Blvd., Manila 1015 ,","place":["Philippines"]},{"name":"University of Santo Tomas Department of Biological Sciences, College of Science, , Espa\u00f1a Blvd. 1015, Manila ,","place":["Philippines"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melfei E","family":"Bungihan","sequence":"additional","affiliation":[{"name":"Bioactive Natural Products Discovery Laboratory, Research Center for the Natural and Applied Sciences, University of Santo Tomas , Espan\u0303a Blvd., Manila 1015 ,","place":["Philippines"]},{"name":"University of Santo Tomas Department of Chemistry, College of Science, , Espan\u0303a Blvd., Manila 1015 ,","place":["Philippines"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeles M","family":"De\u00a0Leon","sequence":"additional","affiliation":[{"name":"Central Luzon State University Department of Biological Sciences, College of Science, , Science City of Mun\u0303oz, Nueva Ecija ,","place":["Philippines"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa H","family":"Pecundo","sequence":"additional","affiliation":[{"name":"Fungal Biodiversity, Ecogenomics and Systematics-Metabolomics (FBeS) Group, Research Center for the Natural and Applied Sciences, University of Santo Tomas , Espa\u00f1a Blvd., Manila 1015 ,","place":["Philippines"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Osaki-Oka","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Tottori University , 4-101, Koyama-cho Minami, Tottori 680-8553 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Kido","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Tottori University , 4-101, Koyama-cho Minami, Tottori 680-8553 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoichiro","family":"Kodama","sequence":"additional","affiliation":[{"name":"The United Graduate School of Agricultural Sciences, Tottori University , Tottori 680-8553 ,","place":["Japan"]},{"name":"Faculty of Agriculture, Tottori University , 4-101, Koyama-cho Minami, Tottori 680-8553 ,","place":["Japan"]},{"name":"Faculty of Life and Environmental Sciences, Shimane University , Matsue 690-8504 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4604-6608","authenticated-orcid":false,"given":"Tsutomu","family":"Arie","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Tokyo University of Agriculture and Technology , Fuchu, Tokyo 183-8509 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3227-2073","authenticated-orcid":false,"given":"Kotomi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Tottori University , 4-101, Koyama-cho Minami, Tottori 680-8553 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Edison E","family":"dela\u00a0Cruz","sequence":"additional","affiliation":[{"name":"University of Santo Tomas Department of Biological Sciences, College of Science, , Espa\u00f1a Blvd. 1015, Manila ,","place":["Philippines"]},{"name":"Fungal 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